(Q39538005)

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Functional interplay between melatonin receptor-mediated antiproliferative signaling and androgen receptor signaling in human prostate epithelial cells: potential implications for therapeutic strategies against prostate cancer.

scientific article published on 24 May 2011

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Europe PubMed Central

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1 February 2020

Functional interplay between melatonin receptor-mediated antiproliferative signaling and androgen receptor signaling in human prostate epithelial cells: potential implications for therapeutic strategies against prostate cancer (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21605164%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

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prostate cancer

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based on heuristic

inferred from title

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Europe PubMed Central

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1 February 2020

author name string

Chun W Tam

1

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1 February 2020

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24 May 2011

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1 February 2020

Journal of Pineal Research

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1 February 2020

51

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1 February 2020

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1 February 2020

297-312

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1 February 2020

Cancer statistics, 2009

1 reference

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Novel targets for prostate cancer chemoprevention

1 reference

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21 January 2018

Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gα(s) and Gα(q) proteins.

1 reference

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Carcinogenicity of shift-work, painting, and fire-fighting

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Light-at-night, circadian disruption and breast cancer: assessment of existing evidence

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Prospective cohort study of the risk of prostate cancer among rotating-shift workers: findings from the Japan collaborative cohort study.

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21 January 2018

Melatonin, sleep disturbance and cancer risk

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Light-mediated perturbations of circadian timing and cancer risk: a mechanistic analysis.

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Light at night activates IGF-1R/PDK1 signaling and accelerates tumor growth in human breast cancer xenografts.

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Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats

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Therapeutic actions of melatonin in cancer: possible mechanisms

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21 January 2018

Basic Mechanisms Involved in the Anti-Cancer Effects of Melatonin

1 reference

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21 January 2018

Global co-distribution of light at night (LAN) and cancers of prostate, colon, and lung in men.

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21 January 2018

Light at night, chronodisruption, melatonin suppression, and cancer risk: a review

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21 January 2018

Towards rational and evidence-based use of melatonin in prostate cancer prevention and treatment.

1 reference

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21 January 2018

Potential involvement of mt1 receptor and attenuated sex steroid-induced calcium influx in the direct anti-proliferative action of melatonin on androgen-responsive LNCaP human prostate cancer cells.

1 reference

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21 January 2018

Inhibition of androgen-sensitive LNCaP prostate cancer growth in vivo by melatonin: association of antiproliferative action of the pineal hormone with mt1 receptor protein expression

1 reference

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21 January 2018

Melatonin and prostate cancer cell proliferation: interplay with castration, epidermal growth factor, and androgen sensitivity

1 reference

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21 January 2018

Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype

1 reference

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21 January 2018

Signaling mechanisms of melatonin in antiproliferation of hormone-refractory 22Rv1 human prostate cancer cells: implications for prostate cancer chemoprevention

1 reference

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21 January 2018

Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance.

1 reference

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21 January 2018

Anti-androgens and androgen-depleting therapies in prostate cancer: new agents for an established target

1 reference

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21 January 2018

Androgen deprivation therapy for prostate cancer: current status and future prospects

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21 January 2018

Steroid hormone receptors in prostate cancer: a hard habit to break?

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21 January 2018

A role for GATA transcription factors in the androgen regulation of the prostate-specific antigen gene enhancer

1 reference

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21 January 2018

Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18

1 reference

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21 January 2018

A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens

1 reference

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21 January 2018

Molecular characterization of human prostate carcinoma cell lines

1 reference

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21 January 2018

Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer

1 reference

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21 January 2018

Androgen receptor expression in androgen-independent prostate cancer cell lines

1 reference

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21 January 2018

Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance

1 reference

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21 January 2018

Identification of novel truncated androgen receptor (AR) mutants including unreported pre-mRNA splicing variants in the 22Rv1 hormone-refractory prostate cancer (PCa) cell line.

1 reference

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21 January 2018

Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer

1 reference

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21 January 2018

Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism

1 reference

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21 January 2018

RGS2: a multifunctional regulator of G-protein signaling

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Melatonin elicits nuclear exclusion of the human androgen receptor and attenuates its activity

1 reference

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21 January 2018

Seasonality of serum prostate-specific antigen levels: a population-based study

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21 January 2018

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

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TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions

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21 January 2018

Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven.

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Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer

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Melatonin down-regulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells.

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Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

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Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1α inactivation in hypoxic PC-3 prostate cancer cells

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The androgen axis in recurrent prostate cancer

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Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

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Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer

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Identifiers

10.1111/J.1600-079X.2011.00890.X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21605164%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21605164%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

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