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Adenovirus type 5 E4orf3 protein relieves p53 inhibition by E1B-55-kilodalton protein.
scientific article published on March 1999
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scholarly article
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stated in
Europe PubMed Central
PMCID
104470
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9971808%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 December 2019
title
Adenovirus type 5 E4orf3 protein relieves p53 inhibition by E1B-55-kilodalton protein
(English)
1 reference
stated in
Europe PubMed Central
PMCID
104470
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9971808%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 December 2019
main subject
Adenoviridae
1 reference
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inferred from title
author
Matthias Dobbelstein
series ordinal
3
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Europe PubMed Central
PMCID
104470
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9971808%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 December 2019
author name string
König C
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
104470
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9971808%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 December 2019
Roth J
series ordinal
2
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Europe PubMed Central
PMCID
104470
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9971808%20AND%20SRC:MED&resulttype=core&format=json
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11 December 2019
language of work or name
English
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publication date
1 March 1999
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stated in
Europe PubMed Central
PMCID
104470
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9971808%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 December 2019
published in
Journal of Virology
1 reference
stated in
Europe PubMed Central
PMCID
104470
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9971808%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 December 2019
volume
73
1 reference
stated in
Europe PubMed Central
PMCID
104470
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9971808%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 December 2019
page(s)
2253-2262
1 reference
stated in
Europe PubMed Central
PMCID
104470
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9971808%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 December 2019
issue
3
1 reference
stated in
Europe PubMed Central
PMCID
104470
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9971808%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 December 2019
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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.
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Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence
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Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.
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The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor function
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Adenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells.
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The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway
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p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.
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Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein
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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
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p53 modulation of TFIIH-associated nucleotide excision repair activity
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Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells
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Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff
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The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs
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Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport
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Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection
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Suppression of human colorectal carcinoma cell growth by wild-type p53
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p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain
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Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids
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Inhibition of HeLa cell protein synthesis during adenovirus infection. Restriction of cellular messenger RNA sequences to the nucleus
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Intracistronic complementation reveals a new function of SV40 T antigen that co-operates with Rb and p53 binding to stimulate DNA synthesis in quiescent cells
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Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor
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25 September 2017
Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure.
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25 September 2017
Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104470
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The intracellular distribution of the transformation-associated protein p53 in adenovirus-transformed rodent cells.
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15 June 2018
Localization of the E1B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104470
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15 June 2018
Transactivation of the p53 oncogene by E1a gene products
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104470
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15 June 2018
The human cytomegalovirus IE2 86 kDa protein elevates p53 levels and transactivates the p53 promoter in human fibroblasts.
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=104470
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21 August 2018
Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.
1 reference
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21 August 2018
A monoclonal antibody detecting the adenovirus type 5-E1b-58Kd tumor antigen: characterization of the E1b-58Kd tumor antigen in adenovirus-infected and -transformed cells
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21 August 2018
Identification of intranuclear structures containing the 72K DNA-binding protein of human adenovirus type 5
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9971808
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9971808
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/9971808
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/JVI.73.3.2253-2262.1999
0 references
PMCID
104470
1 reference
stated in
Europe PubMed Central
PMCID
104470
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9971808%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 December 2019
PubMed ID
9971808
1 reference
stated in
Europe PubMed Central
PMCID
104470
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9971808%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 December 2019
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