(Q39560150)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

title

CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

0 references

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

author name string

Xiangrui Liu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Shenhua Shi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Frankie Lam

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Chris Pepper

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Shudong Wang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

language of work or name

English

0 references

publication date

21 June 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

International Journal of Cancer

28 January 2020

number of pages

11

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

volume

130

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

page(s)

1216-1226

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21484792%20AND%20SRC:MED&resulttype=core&format=json

Recent progress in the discovery and development of cyclin-dependent kinase inhibitors

28 January 2020

cites work

1 reference

Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology.

21 January 2018

1 reference

Cell cycle kinases as therapeutic targets for cancer

21 January 2018

1 reference

Mice thrive without Cdk4 and Cdk2.

21 January 2018

1 reference

Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death

21 January 2018

1 reference

Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia

21 January 2018

1 reference

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.

21 January 2018

1 reference

Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.

21 January 2018

1 reference

Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity

21 January 2018

1 reference

Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors

21 January 2018

1 reference

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity

21 January 2018

1 reference

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

1 reference

Characteristics of a human diploid cell designated MRC-5.

21 January 2018

1 reference

Genomic instability in mice lacking histone H2AX

21 January 2018

1 reference

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

1 reference

Histone H2A variants H2AX and H2AZ

21 January 2018

1 reference

A simple technique for quantitation of low levels of DNA damage in individual cells

21 January 2018

1 reference

Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells

21 January 2018

1 reference

Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells

21 January 2018

1 reference

Cdk2 knockout mice are viable

21 January 2018

1 reference

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

21 January 2018

1 reference

Cdk1 is sufficient to drive the mammalian cell cycle

21 January 2018

1 reference

Cyclin-dependent kinase pathways as targets for cancer treatment

21 January 2018

1 reference

Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol

21 January 2018

1 reference

Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II.

21 January 2018

1 reference

Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences

21 January 2018

1 reference

AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.

21 January 2018

1 reference

Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis

21 January 2018

1 reference

mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation

21 January 2018

1 reference

21 January 2018

1 reference

Proteolytic regulation of apoptosis

21 January 2018

1 reference

The protein structures that shape caspase activity, specificity, activation and inhibition

21 January 2018

1 reference

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

1 reference

Cell death: critical control points

21 January 2018

1 reference

BCL-2 family proteins: critical checkpoints of apoptotic cell death

21 January 2018

1 reference

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

1 reference

Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia

21 January 2018

1 reference

Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

21 January 2018

1 reference

Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol

21 January 2018

1 reference