(Q39561464)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

title

Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

Afadin, adherens junction formation factor

28 January 2020

main subject

1 reference

negative regulation of cell migration

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

cell migration

1 reference

based on heuristic

inferred from title

neoplastic invasiveness

1 reference

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

Daniel Birnbaum

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

author name string

G Fournier

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

O Cabaud

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

E Josselin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

A Chaix

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

J Adélaïde

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

D Isnardon

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

A Restouin

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

R Castellano

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

M Chaffanet

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

M Lopez

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

language of work or name

English

0 references

publication date

11 April 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

volume

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

issue

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

page(s)

3862-3874

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/onc.2011.106

28 January 2020

exact match

0 references

cites work

Integrated profiling of basal and luminal breast cancers.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

AF6/s-afadin is a dual residency protein and localizes to a novel subnuclear compartment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and Dishevelled

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Regulation of cell motility by mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Memo mediates ErbB2-driven cell motility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

The Canoe protein is necessary in adherens junctions for development of ommatidial architecture in the Drosophila compound eye.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

canoe encodes a novel protein containing a GLGF/DHR motif and functions with Notch and scabrous in common developmental pathways in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2: implications for cellular morphology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

AF-6/cno: neither a kinesin nor a myosin, but a bit of both.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Regulation of c-Src by binding to the PDZ domain of AF-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Complete genomic structure DNA polymorphisms, and alternative splicing of the human AF-6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Direct binding between two PDZ domain proteins Canoe and ZO-1 and their roles in regulation of the jun N-terminal kinase pathway in Drosophila morphogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

In vivo interaction of AF-6 with activated Ras and ZO-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Profilin-1 is a negative regulator of mammary carcinoma aggressiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Silencing profilin-1 inhibits endothelial cell proliferation, migration and cord morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

Serine phosphorylation of paxillin by heregulin-beta1: role of p38 mitogen activated protein kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.106

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.106

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478912%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

1 reference