(Q39561471)

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Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells.

scientific article published on 11 April 2011

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28 January 2020

Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells (English)

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28 January 2020

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28 January 2020

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28 January 2020

Øyvind Sverre Bruland

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28 January 2020

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U-M Fagerli

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28 January 2020

K Ullrich

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28 January 2020

T Stühmer

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28 January 2020

K Köchert

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28 January 2020

R U Holt

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28 January 2020

M Chatterjee

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28 January 2020

H Nogai

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28 January 2020

G Lenz

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28 January 2020

J D Shaughnessy

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28 January 2020

S Mathas

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28 January 2020

A Sundan

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28 January 2020

R C Bargou

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28 January 2020

B Dörken

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28 January 2020

M Janz

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28 January 2020

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11 April 2011

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28 January 2020

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28 January 2020

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28 January 2020

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28 January 2020

3198-3206

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28 January 2020

https://scigraph.springernature.com/pub.10.1038/onc.2011.79

0 references

Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

The AKT kinase is activated in multiple myeloma tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Bone marrow microenvironment and the identification of new targets for myeloma therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Serum/glucocorticoid-induced protein kinase-1 facilitates androgen receptor-dependent cell survival

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Chimaeric anti-interleukin 6 monoclonal antibodies in the treatment of advanced multiple myeloma: a phase I dose-escalating study

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Combined functional and molecular analysis of tumor cell signaling defines 2 distinct myeloma subgroups: Akt-dependent and Akt-independent multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

21 January 2018

Coordinate expression of the PI3-kinase downstream effectors serum and glucocorticoid-induced kinase (SGK-1) and Akt-1 in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.79

31 March 2020

Identifiers

10.1038/ONC.2011.79

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478911%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

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28 January 2020

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