(Q39568018)

13 September 2017

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title

The potential use of mechanism-based enzyme inactivators in medicine (English)

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13 September 2017

Silverman RB

1

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13 September 2017

publication date

1 January 1988

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Journal of Enzyme Inhibition and Medicinal Chemistry

13 September 2017

published in

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13 September 2017

volume

2

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13 September 2017

issue

2

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13 September 2017

page(s)

73-90

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Adenosine analogues as substrates and inhibitors of S-adenosylhomocysteine hydrolase

13 September 2017

cites work

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Affinity-chromatographic purification of S-adenosyl-l-homocysteine hydrolase. Some properties of the enzyme from rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inactivation of liver S-adenosylhomocysteine hydrolase in vitro of rats treated with erythro-9-(2-hydroxynon-3-yl)adenine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Organofluorine synthesis via photofluorination: 3-fluoro-D-alanine and 2-deuterio analogue, antibacterials related to the bacterial cell wall

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Selective inhibitors of biosynthesis of aminergic neurotransmitters

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Suicide substrates for the alanine racemase of Escherichia coli B

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Biosynthetic alanine racemase of Salmonella typhimurium: purification and characterization of the enzyme encoded by the alr gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inactivation of the dadB Salmonella typhimurium alanine racemase by D and L isomers of beta-substituted alanines: kinetics, stoichiometry, active site peptide sequencing, and reaction mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inhibition of bacterial growth by beta-chloro-D-alanine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

beta-elimination of beta-halo substrates by D-amino acid transaminase associated with inactivation of the enzyme. Trapping of a key intermediate in the reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Enzyme-activated inhibition of bacterial D-amino acid transaminase by beta-cyano-D-alanine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Mechanism of inactivation of gamma-aminobutyrate aminotransferase by 4-amino-5-fluoropentanoic acid. First example of an enamine mechanism for a gamma-amino acid with a partition ratio of 0.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

omega-Fluoromethyl analogues of omega-amino acids as irreversible inhibitors of 4-aminobutyrate:2-oxoglutarate aminotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inactivation of gamma-aminobutyric acid aminotransferase by (S,E)-4-amino-5-fluoropent-2-enoic acid and effect on the enzyme of (E)-3-(1-aminocyclopropyl)-2-propenoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Enzyme-activated irreversible inhibition of rat and mouse brain 4-aminobutyric acid-alpha-ketoglutarate transaminase by 5-fluoro-4-oxo-pentanoic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Irreversible inhibition of GABA-T by halogenated analogues of beta-alanine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

The reaction of ethanolamine O-sulphate with 4-aminobutyrate aminotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Stereochemistry of Reactions Catalysed by Mammalian-Brain L-Glutamate 1-Carboxy-lyase and 4-Aminobutyrate: 2-Oxoglutarate Aminotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Stereochemistry of the inactivation of 4-aminobutyrate: 2-oxoglutarate aminotransferase and l-glutamate 1-carboxylase by 4-aminohex-5-ynoic acid enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Enzyme-induced inactivation of transminases by acetylenic and vinyl analogues of 4-aminobutyrate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Gamma-allenyl GABA, a new inhibitor of 4-amino butyrate amino transferase. Comparison with other inhibitors of this enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

4-amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Synthesis and evaluation of mono-, di-, and trifluoroethenyl-GABA derivatives as GABA-T inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

CYCLOSERINE INHIBITION OF GAMMA-AMINOBUTYRIC-ALPHA-KETOGLUTARIC TRANSAMINASE.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Catalytic irreversible inhibition of bacterial and plant arginine decarboxylase activities by novel substrate and product analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inhibition and inactivation of estrogen synthetase (aromatase) by fluorinated substrate analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Thiol-containing androgens as suicide substrates of aromatase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inhibition of monoamine synthesis by irreversible blockade of aromatic aminoacid decarboxylase with α-monofluoromethyldopa

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inhibition of aromatic amino acid decarboxylase and depletion of biogenic amines in brain of rats treated with alpha-monofluoromethyl p-tyrosine: similitudes and differences with the effects of alpha-monofluoromethyldopa

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inactivation of 3-(3,4-dihydroxyphenyl)alanine decarboxylase by 2-(fluoromethyl)-3-(3,4-dihydroxyphenyl)alanine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

In vitro and in vivo effects of alpha-acetylenic DOPA and alpha-vinyl DOPA on aromatic L-amino acid decarboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

3-Phenylpropenes as mechanism-based inhibitors of dopamine beta-hydroxylase: evidence for a radical mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Dopamine-B-hydroxylase: suicide inhibition by the novel olefinic substrate, 1-phenyl-1-aminomethylethene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inhibition of histamine synthesis in brain by alpha-fluoromethylhistidine, a new irreversible inhibitor: in vitro and in vivo studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

In vivo and in vitro inhibition of human histidine decarboxylase by (S)-alpha-fluoromethylhistidine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Mechanism of inactivation of mammalian L-histidine decarboxylase by (S)-alpha-fluoromethylhistidine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inhibition of histamine synthesis in vitro and in vivo by S-alpha-fluoromethylhistidine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

21 January 2018

β-Lactamase inhibitors

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Structure-activity relationships amongst beta-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Mechanism of inactivation of TEM-1 β-lactamase by 6-acetylmethylenepenicillanic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

CP-45,899, a Beta-Lactamase Inhibitor That Extends the Antibacterial Spectrum of Beta-Lactams: Initial Bacteriological Characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Comparative Inhibition of β-Lactamases by Novel β-Lactam Compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inhibition kinetics of three R-factor-mediated β-lactamases by a new β-lactam sulfone (CP 45899)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inhibition of class C beta-lactamases by (1'R,6R)-6-(1'-hydroxy)benzylpenicillanic acid SS-dioxide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Penicillinase active sites: Labelling of serine-44 in β-lactamase I by 6β-bromopenicillanic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inactivation of Bacillus cereus beta-lactamase I by 6 beta-bromopencillanic acid: mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

The active sites of the beta-lactamases of Streptomyces cacaoi and Streptomyces albus G

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

A semi-synthetic penicillinase inactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

The inhibition of beta-lactamases from gram-negative bacteria by clavulanic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inhibition of β-lactamase of Bacillus licheniformis 749/C by compound PS-5, a new β-lactam antibiotic

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Monoamine oxidase—II Time-dependent inhibition by propargylamines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Selective acetylenic 'suicide' and reversible inhibitors of monoamine oxidase types A and B

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

The nature of the inhibition of rat liver monoamine oxidase types A and B by the acetylenic inhibitors clorgyline, l-deprenyl and pargyline

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

The structure of the covalent adduct formed by the interaction of 3-dimethylamino-1-propyne and the flavine of mitochondrial amine oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Reversible inhibition and mechanism-based irreversible inactivation of monoamine oxidases by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

(Z)-2-(2,4-Dichlorophenoxy)methyl-3-fluoroallylamine (MDL 72638): a clorgyline analogue with surprising selectivity for monoamine oxidase type B.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Kinetic studies and effects in vivo of a new monoamine oxidase inhibitor, N[2(ochlorophenoxy)-ethyl]-cyclopropylamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

N-substituted cyclopropylamines as monoamine oxidase inhibitors. Structure-activity relationships. Dopa potentiation in mice and in vitro inhibition of kynuramine oxidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Effect of alpha-methylation on inactivation of monoamine oxidase by N-cyclopropylbenzylamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Identification of the amino acid bound to the labile adduct formed during inactivation of monoamine oxidase by 1-phenylcyclopropylamine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Benzylhydrazine—A selective inhibitor of human and rat brain monoamine oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

alpha-Monofluoromethyl and alpha-difluoromethyl putrescine as ornithine decarboxylase inhibitors: in vitro and in vivo biochemical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

alpha-(Fluoromethyl)dehydroornithine and alpha-(fluoromethyl)dehydroputrescine analogues as irreversible inhibitors of ornithine decarboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

DL-a-Monofluoromethylputrescine is a potent irreversible inhibitor of Escherichia coli ornithine decarboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

alpha-Allenyl putrescine, an enzyme-activated irreversible inhibitor of bacterial and mammalian ornithine decarboxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Restriction of bacterial growth by inhibition of polyamine biosynthesis by using monofluoromethylornithine, difluoromethylarginine and dicyclohexylammonium sulphate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inhibitors of leukocyte elastase and leukocyte cathepsin G. Agents for the treatment of emphysema and related ailments

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Kinetics and mechanism of human leukocyte elastase inactivation by ynenol lactones

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Novel inactivators of serine proteases based on 6-chloro-2-pyrone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Reaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: new reactive mechanism-based inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Mechanism of inactivation of chymotrypsin by 5-butyl-3H-1,3-oxazine-2,6-dione

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Amino acid derived latent isocyanates: irreversible inactivation of porcine pancreatic elastase and human leukocyte elastase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

The Lossen rearrangement in biological systems. Inactivation of leukocyte elastase and alpha-chymotrypsin by (dl)-3-benzyl-N-(methanesulfonyloxy) succinimide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Mechanism of inactivation of human leukocyte elastase by a chloromethyl ketone: kinetic and solvent isotope effect studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Inhibition of testosterone 5 alpha-reductase by a proposed enzyme-activated, active site-directed inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

The effect of raney nickel on the covalent thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Fluorine-19 nuclear magnetic resonance characterization of ternary complexes of folate derivatives, 5-fluorodeoxyuridylate and Lactobacillus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Interaction of 1-(5-phospho-.beta.-D-arabinofuranosyl)-5-substituted-uracils with thymidylate synthetase: mechanism-based inhibition by 1-(5-phospho-.beta.-D-arabinofurosyl)-5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Mechanism of action of 2',5-difluoro-1-arabinosyluracil

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Trans-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

Reaction of 5-ethynyl-2'-deoxyuridylate with thiols and thymidylate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F14756368809040714

A novel beta-lactamase inhibitor, SF-2103 A produced by a Streptomyces

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.35.533

Identifiers

DOI

10.3109/14756368809040714

1 reference

13 September 2017

1 reference