(Q39568959)

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An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer.

scientific article published on 27 April 2011

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21445882%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21445882%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

monoclonal antibody

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based on heuristic

inferred from title

Andrew J Racher

6

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26 January 2020

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Jane McLeod

1

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26 January 2020

Peter M O'Callaghan

2

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26 January 2020

Leon P Pybus

3

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26 January 2020

Stephen J Wilkinson

4

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26 January 2020

Tracy Root

5

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26 January 2020

David C James

7

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26 January 2020

publication date

27 April 2011

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26 January 2020

Biotechnology and Bioengineering

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26 January 2020

108

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26 January 2020

9

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26 January 2020

2193-2204

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26 January 2020

Transgenes encompassing dual-promoter CpG islands from the human TBP and HNRPA2B1 loci are resistant to heterochromatin-mediated silencing

1 reference

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A structured model for monoclonal antibody synthesis in exponentially growing and stationary phase hybridoma cells

1 reference

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21 January 2018

Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line

1 reference

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21 January 2018

A 'top-down' approach to the determination of control coefficients in metabolic control theory.

1 reference

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21 January 2018

Properties of the proximate parameter tuning regularization algorithm.

1 reference

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21 January 2018

Codon engineering for improved antibody expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Accurate and objective copy number profiling using real-time quantitative PCR.

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21 January 2018

Control of translation initiation: a model-based analysis from limited experimental data

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Immunoglobulin Light Chains Dictate Vesicular Transport-dependent and -independent Routes for IgM Degradation by the Ubiquitin-Proteasome Pathway

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Metabolic control analysis: a survey of its theoretical and experimental development

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Use of the chicken lysozyme 5' matrix attachment region to generate high producer CHO cell lines.

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Metabolic control analysis of monoclonal antibody synthesis

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Development and analysis of a mathematical model for antibody-producing GS-NS0 cells under normal and hyperosmotic culture conditions

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

mRNA stability and antibody production in CHO cells: improvement through gene optimization

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Toward more efficient protein expression: keep the message simple.

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

The level of synthesis and secretion of Gaussia princeps luciferase in transfected CHO cells is heavily dependent on the choice of signal peptide

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

An efficient homologous recombination vector pTV(I) contains a hot spot for increased recombinant protein expression in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Optimised mammalian expression through the coupling of codon adaptation with gene amplification: maximum yields with minimum effort

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Identification of cellular genes critical to recombinant protein production using a Gaussia luciferase-based siRNA screening system

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Effect of doxycycline-regulated protein disulfide isomerase expression on the specific productivity of recombinant CHO cells: thrombopoietin and antibody

1 reference

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21 January 2018

Systems biotechnology of mammalian cell factories

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Cell line-specific control of recombinant monoclonal antibody production by CHO cells.

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Molecular engineering of exocytic vesicle traffic enhances the productivity of Chinese hamster ovary cells

1 reference

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21 January 2018

The vesicle-trafficking protein munc18b increases the secretory capacity of mammalian cells

1 reference

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21 January 2018

Genomics of mRNA turnover.

1 reference

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21 January 2018

Strategies for selecting recombinant CHO cell lines for cGMP manufacturing: improving the efficiency of cell line generation.

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Strategies for selecting recombinant CHO cell lines for cGMP manufacturing: realizing the potential in bioreactors

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

High-level expression of proteins in mammalian cells using transcription regulatory sequences from the Chinese hamster EF-1alpha gene

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

On the optimal ratio of heavy to light chain genes for efficient recombinant antibody production by CHO cells.

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Use and limitations of modular metabolic control analysis in medicine and biotechnology.

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Modular analysis of the control of complex metabolic pathways.

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Dynamic analysis of GS-NS0 cells producing a recombinant monoclonal antibody during fed-batch culture.

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Systems biology towards life in silico: mathematics of the control of living cells.

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Modeling assembly, aggregation, and chaperoning of immunoglobulin G production in insect cells

1 reference

https://api.crossref.org/works/10.1002%2FBIT.23146

21 January 2018

Proximate parameter tuning for biochemical networks with uncertain kinetic parameters.

1 reference

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21 January 2018

Degradation of distinct assembly forms of immunoglobulin M occurs in multiple sites in permeabilized B cells

1 reference

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21 January 2018

A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors

1 reference

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Identifiers

10.1002/BIT.23146

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21445882%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21445882%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

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