(Q39574706)

13 September 2017

Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes (English)

1 reference

13 September 2017

Gringhuis SI

1

1 reference

13 September 2017

de Leij LF

series ordinal

2

1 reference

13 September 2017

Coffer PJ

series ordinal

3

1 reference

13 September 2017

Vellenga E

series ordinal

4

1 reference

13 September 2017

language of work or name

English

0 references

publication date

1 March 1998

1 reference

Molecular and Cellular Biology

13 September 2017

1 reference

13 September 2017

18

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13 September 2017

3

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13 September 2017

1725-1735

1 reference

describes a project that uses

13 September 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC108887/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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The modular phosphorylation and activation of p70s6k.

14 September 2017

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Signalling through the lipid products of phosphoinositide-3-OH kinase

14 September 2017

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Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity

14 September 2017

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Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

14 September 2017

1 reference

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Thymocyte activation induces the association of phosphatidylinositol 3-kinase and pp120 with CD5

14 September 2017

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Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

14 September 2017

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Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes

14 September 2017

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Lck regulates Vav activation of members of the Rho family of GTPases

14 September 2017

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

14 September 2017

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

14 September 2017

1 reference

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Regulation of transcription by MAP kinase cascades

14 September 2017

1 reference

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Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

14 September 2017

1 reference

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Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

14 September 2017

1 reference

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Requirements for calcium and calmodulin in the calmodulin kinase activation cascade

14 September 2017

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The PH domain: a common piece in the structural patchwork of signalling proteins

14 September 2017

1 reference

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Vav binds to several SH2/SH3 containing proteins in activated lymphocytes.

14 September 2017

1 reference

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Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.

14 September 2017

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

14 September 2017

1 reference

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1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

14 September 2017

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

14 September 2017

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The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

SH2 domains recognize specific phosphopeptide sequences

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

A functional T-cell receptor signaling pathway is required for p95vav activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

The B-cell surface protein CD72/Lyb-2 is the ligand for CDS

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Evidence for an association between the T cell receptor/CD3 antigen complex and the CD5 antigen in human T lymphocytes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

CD5 is phosphorylated on tyrosine after stimulation of the T-cell antigen receptor complex

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

How B and T cells talk to each other

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Signalling pathways: jack of all cascades

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

PI 3-kinase: a pivotal pathway in T-cell activation?

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

PI3K: downstream AKTion blocks apoptosis

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Activation of Ca2+/calmodulin-dependent protein kinase (CaM-kinase) IV by CaM-kinase kinase in Jurkat T lymphocytes

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Transcriptional regulation of interleukin 3 (IL3) in primary human T lymphocytes. Role of AP-1- and octamer-binding proteins in control of IL3 gene expression

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Activation of the small GTP-binding proteins rho and rac by growth factor receptors.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Developmental expression of the vav protooncogene.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

CD5 antibodies increase intracellular ionized calcium concentration in T cells.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=108887

Induction of human T cell proliferation by a monoclonal antibody to CD5

21 August 2018

1 reference

12 December 2020

Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element

1 reference

12 December 2020

Intracellular events involved in CD5-induced human T cell activation and proliferation

1 reference

12 December 2020

Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation

1 reference

12 December 2020

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase

1 reference

12 December 2020

Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation

1 reference

12 December 2020

The Ca2+/calmodulin-dependent kinase type IV is involved in the CD5-mediated signaling pathway in human T lymphocytes

1 reference

12 December 2020

Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase

1 reference

12 December 2020

Biologic functions of the OKT1 T cell surface antigen. I. The T1 molecule is involved in helper function

1 reference

12 December 2020

Monoclonal antibodies to the CD5 antigen can provide the necessary second signal for activation of isolated resting T cells by solid-phase-bound OKT3

1 reference

12 December 2020

Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin

1 reference

12 December 2020

The CD5/CD72 receptor system is coexpressed with several functionally relevant counterstructures on human B cells and delivers a critical signaling activity

1 reference

12 December 2020

Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters

1 reference

12 December 2020

The vav proto-oncogene product (p95vav) interacts with the Tyk-2 protein tyrosine kinase

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.18.3.1725

1 reference

13 September 2017

1 reference

13 September 2017

PubMed publication ID

9488489

1 reference