(Q39575832)

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Mutations affecting the stability of the haemagglutinin molecule impair the immunogenicity of live attenuated H3N2 intranasal influenza vaccine candidates lacking NS1.

scientific article published on 12 March 2011

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scholarly article

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25 January 2020

Mutations affecting the stability of the haemagglutinin molecule impair the immunogenicity of live attenuated H3N2 intranasal influenza vaccine candidates lacking NS1 (English)

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25 January 2020

attenuated vaccine

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based on heuristic

inferred from title

influenza vaccine

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based on heuristic

inferred from title

6

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25 January 2020

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25 January 2020

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Sabine Nakowitsch

1

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25 January 2020

Markus Wolschek

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25 January 2020

Alexander Morokutti

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25 January 2020

Tanja Ruthsatz

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25 January 2020

Brigitte M Krenn

5

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25 January 2020

Nicole Ferstl

7

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25 January 2020

Andrea Triendl

8

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25 January 2020

Thomas Muster

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25 January 2020

Andrej Egorov

10

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25 January 2020

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publication date

12 March 2011

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25 January 2020

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25 January 2020

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25 January 2020

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25 January 2020

3517-3524

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25 January 2020

Antigenic alteration of influenza B virus associated with loss of a glycosylation site due to host-cell adaptation

1 reference

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The impact of key amino acid substitutions in the hemagglutinin of influenza A (H3N2) viruses on vaccine production and antibody response

1 reference

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7 January 2021

Distinct host range of influenza H3N2 virus isolates in Vero and MDCK cells is determined by cell specific glycosylation pattern.

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Adaptation of egg-grown and transfectant influenza viruses for growth in mammalian cells: selection of hemagglutinin mutants with elevated pH of membrane fusion

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Novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutinin

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A novel type of influenza vaccine: safety and immunogenicity of replication-deficient influenza virus created by deletion of the interferon antagonist NS1.

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A DNA transfection system for generation of influenza A virus from eight plasmids

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Preclinical evaluation of a replication-deficient intranasal DeltaNS1 H5N1 influenza vaccine

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Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems

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Generation of an influenza A virus vector expressing biologically active human interleukin-2 from the NS gene segment

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Influenza B mutant viruses with truncated NS1 proteins grow efficiently in Vero cells and are immunogenic in mice

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Activation of influenza virus by acidic media causes hemolysis and fusion of erythrocytes

1 reference

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Fatty acids on the A/USSR/77 influenza virus hemagglutinin facilitate the transition from hemifusion to fusion pore formation

1 reference

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Structure of influenza haemagglutinin at the pH of membrane fusion

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H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes

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Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin

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Fusion mutants of the influenza virus hemagglutinin glycoprotein

1 reference

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The relevance of salt bridges for the stability of the influenza virus hemagglutinin.

1 reference

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Restrictions to the adaptation of influenza a virus h5 hemagglutinin to the human host.

1 reference

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7 January 2021

Influenza hemagglutinin is spring-loaded by a metastable native conformation

1 reference

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Stability of infectious influenza A viruses at low pH and at elevated temperature

1 reference

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Positive selection on the H3 hemagglutinin gene of human influenza virus A.

1 reference

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Codominant mixtures of viruses in reference strains of influenza virus due to host cell variation

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HA1 domain of influenza A (H3N2) viruses in Finland in 1989-1995: evolution, egg-adaptation and relationship to vaccine strains

1 reference

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7 January 2021

Hemagglutinin polymorphism as the basis for low- and high-yield phenotypes of swine influenza virus

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Mutations at positions 186 and 194 in the HA gene of the 2009 H1N1 pandemic influenza virus improve replication in cell culture and eggs

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Apoptosis by influenza viruses correlates with efficiency of viral mRNA synthesis

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Hemolytic activity of influenza virus hemagglutinin glycoproteins activated in mildly acidic environments

1 reference

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Temperature and pH dependence of the haemolytic activity of influenza virus and of the rotational mobility of the spike glycoproteins

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Nasal pH measurement: a reliable and repeatable parameter

1 reference

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Determination of baseline human nasal pH and the effect of intranasally administered buffers

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Acid secretion and proton conductance in human airway epithelium

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Airway surface pH in subjects with cystic fibrosis

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Mechanisms of acid and base secretion by the airway epithelium

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Aerosol transmission of influenza A virus: a review of new studies

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Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus

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Enhanced immunogenicity of stabilized trimeric soluble influenza hemagglutinin

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Molecular and immunological characterization of soluble aggregated A/Victoria/3/75 (H3N2) influenza haemagglutinin expressed in insect cells

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pH-dependent aggregation and secretion of soluble monomeric influenza hemagglutinin

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1 reference

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based on heuristic

inferred from DOI database lookup

Comparison of Madin-Darby canine kidney cells (MDCK) with a green monkey continuous cell line (Vero) and human lung embryonated cells (MRC-5) in the isolation of influenza A virus from nasopharyngeal aspirates by shell vial culture

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2011.02.100

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based on heuristic

inferred from DOI database lookup

Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays.

1 reference

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based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.VACCINE.2011.02.100

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21406268%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21406268%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

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