(Q39580147)

English

Targeted impairment of thymidine kinase 2 expression in cells induces mitochondrial DNA depletion and reveals molecular mechanisms of compensation of mitochondrial respiratory activity.

scientific article published on 5 March 2011

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Targeted impairment of thymidine kinase 2 expression in cells induces mitochondrial DNA depletion and reveals molecular mechanisms of compensation of mitochondrial respiratory activity (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

mitochondrial DNA

0 references

Joan Villarroya

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

author name string

Mari-Carmen Lara

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Beatriz Dorado

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Marta Garrido

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Elena García-Arumí

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Michio Hirano

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Maya R Vilà

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

language of work or name

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publication date

5 March 2011

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Europe PubMed Central

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24 January 2020

number of pages

6

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inferred from page(s)

Biochemical and Biophysical Research Communications

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

407

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

333-338

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

Altered gene transcription profiles in fibroblasts harboring either TK2 or DGUOK mutations indicate compensatory mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate nucleotide supply for mitochondrial DNA synthesis in mouse L-cells. Effect of 5-fluorodeoxyuridine and methotrexate in thymidine kinase plus and thymidine kinase minus cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and molecular investigations in respiratory chain deficiencies

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective muscle fiber loss and molecular compensation in mitochondrial myopathy due to TK2 deficiency.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

POLG mutations associated with Alpers' syndrome and mitochondrial DNA depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Origins of mitochondrial thymidine triphosphate: Dynamic relations to cytosolic pools

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human mitochondrial DNA is packaged with TFAM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset encephalomyopathy associated with tissue-specific mitochondrial DNA depletion: a morphological, biochemical and molecular-genetic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Infantile hepatocerebral syndromes associated with mutations in the mitochondrial DNA polymerase-gammaA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21382338

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BBRC.2011.03.018

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21382338%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

ResearchGate publication ID

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