(Q39581399)

13 September 2017

title

Discovery and biological activity of 6BrCaQ as an inhibitor of the Hsp90 protein folding machinery (English)

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13 September 2017

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Davide Audisio

1

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13 September 2017

Samir Messaoudi

2

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13 September 2017

Lukasz Cegielkowski

3

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13 September 2017

Jean-François Peyrat

4

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13 September 2017

Jean-Daniel Brion

5

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13 September 2017

Délphine Methy-Gonnot

6

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13 September 2017

Christine Radanyi

7

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13 September 2017

Jack-Michel Renoir

8

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13 September 2017

Mouâd Alami

9

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13 September 2017

publication date

4 March 2011

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13 September 2017

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13 September 2017

volume

6

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13 September 2017

issue

5

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13 September 2017

page(s)

804-815

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Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?

13 September 2017

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https://api.crossref.org/works/10.1002%2FCMDC.201000489

Structure-based and in silico design of Hsp90 inhibitors

21 January 2018

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Recent advances in Hsp90 inhibitors as antitumor agents

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ATPase inhibitors of heat-shock protein 90, second season

21 January 2018

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Heat shock protein 90: the cancer chaperone

21 January 2018

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Natural product inhibitors of Hsp90: potential leads for drug discovery

21 January 2018

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HSP90 as a new therapeutic target for cancer therapy: the story unfolds

21 January 2018

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HSP90 and the chaperoning of cancer

21 January 2018

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Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000489

Inhibitors of the HSP90 molecular chaperone: current status

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000489

Targeting Hsp90: small-molecule inhibitors and their clinical development

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000489

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000489

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000489

Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000489

Integrin adhesion receptors in tumor metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock protein 90 (hsp90).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000489

Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

A site selective C-H arylation of free-(NH2) adenines with aryl chlorides: application to the synthesis of 6,8-disubstituted adenines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Evaluation of glycine site antagonists of the NMDA receptor in global cerebral ischaemia

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201000489

The synthesis and structure-activity relationships of 3-amino-4-benzylquinolin-2-ones; discovery of novel KCNQ2 channel openers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Structure-activity relationships in a series of 3-sulfonylamino-2-(1H)-quinolones, as new AMPA/kainate and glycine antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Structure-activity relationships of 4-hydroxy-3-nitroquinolin-2(1H)-ones as novel antagonists at the glycine site of N-methyl-D-aspartate receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Synthesis and pharmacological studies at the Gly/NMDA, AMPA and Kainate receptors of new oxazolo[4,5-c]quinolin-4-one derivatives bearing different substituents at position-2 and on the fused benzo ring

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Molecular chaperones and protein kinase quality control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Apoptosis in the absence of caspase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Properties of the co-chaperone protein p23 erroneously attributed to ALG-2 (apoptosis-linked gene 2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

The co-chaperone p23 is degraded by caspases and the proteasome during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

A survey of telomerase activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Autophagy in the eukaryotic cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Autophagy in health and disease: a double-edged sword

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

7 January 2021

Structure-activity relationships in a series of 2(1H)-quinolones bearing different acidic function in the 3-position: 6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid, a new potent and selective AMPA/kainate antagonist with neuroprotective properti

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

7 January 2021

3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

7 January 2021

4-Hydroxy-3-nitro-2-quinolones and related compounds as inhibitors of allergic reactions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000489

7 January 2021

Identifiers

DOI

10.1002/CMDC.201000489

1 reference

13 September 2017

1 reference