(Q39590627)

13 September 2017

title

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose (English)

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13 September 2017

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Michael J Gramer

1

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13 September 2017

Jackie J Eckblad

2

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13 September 2017

Ruth Donahue

3

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13 September 2017

Joseph Brown

4

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13 September 2017

Carrie Shultz

5

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13 September 2017

Kent Vickerman

6

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13 September 2017

Patrick Priem

7

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13 September 2017

Ewald T J van den Bremer

8

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13 September 2017

Jolanda Gerritsen

9

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13 September 2017

Patrick H C van Berkel

10

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13 September 2017

publication date

18 February 2011

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Biotechnology and Bioengineering

13 September 2017

published in

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13 September 2017

volume

108

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13 September 2017

issue

7

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13 September 2017

page(s)

1591-1602

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Considerations on the lactate consumption by CHO cells in the presence of galactose

13 September 2017

cites work

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The effect of ammonia on the O-linked glycosylation of granulocyte colony-stimulating factor produced by chinese hamster ovary cells

21 January 2018

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Optimisation of the cellular metabolism of glycosylation for recombinant proteins produced by Mammalian cell systems

21 January 2018

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Cell lines with reduced UDP-N-acetylhexosamine pool in the presence of ammonium

21 January 2018

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Effects of elevated ammonium on glycosylation gene expression in CHO cells

21 January 2018

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Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose

21 January 2018

1 reference

Gene-expression profiles for five key glycosylation genes for galactose-fed CHO cells expressing recombinant IL-4/13 cytokine trap

21 January 2018

1 reference

Amino acid and manganese supplementation modulates the glycosylation state of erythropoietin in a CHO culture system.

21 January 2018

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Incorporation of 15N from ammonium into the N-linked oligosaccharides of an immunoadhesin glycoprotein expressed in Chinese hamster ovary cells

21 January 2018

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Ammonium alters N-glycan structures of recombinant TNFR-IgG: degradative versus biosynthetic mechanisms

21 January 2018

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Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins

21 January 2018

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An HPLC-MALDI MS method for N-glycan analyses using smaller size samples: application to monitor glycan modulation by medium conditions

21 January 2018

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Physiological responses of CHO cells to repetitive hydrodynamic stress.

21 January 2018

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The oligosaccharides of glycoproteins: bioprocess factors affecting oligosaccharide structure and their effect on glycoprotein properties

21 January 2018

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Glycosidase activities in Chinese hamster ovary cell lysate and cell culture supernatant

21 January 2018

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Intracellular UDP-N-acetylhexosamine pool affects N-glycan complexity: a mechanism of ammonium action on protein glycosylation

21 January 2018

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Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells

21 January 2018

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Control of recombinant monoclonal antibody effector functions by Fc N-glycan remodeling in vitro

21 January 2018

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Substitution of glutamine by glutamate enhances production and galactosylation of recombinant IgG in Chinese hamster ovary cells

21 January 2018

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Optimal and consistent protein glycosylation in mammalian cell culture

21 January 2018

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Glycosylation of recombinant antibody therapeutics

21 January 2018

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Glycosylation as a strategy to improve antibody-based therapeutics

21 January 2018

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Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types

21 January 2018

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Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

21 January 2018

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Dissolved oxygen concentration in serum-free continuous culture affects N-linked glycosylation of a monoclonal antibody.

21 January 2018

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Comparisons of the glycosylation of a monoclonal antibody produced under nominally identical cell culture conditions in two different bioreactors

21 January 2018

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Control of IgG/Fc glycosylation: a comparison of oligosaccharides from chimeric human/mouse and mouse subclass immunoglobulin Gs.

21 January 2018

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Glycosylation of an immunoglobulin produced from a murine hybridoma cell line: the effect of culture mode and the anti-apoptotic gene, bcl-2.

21 January 2018

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Effects of buffering conditions and culture pH on production rates and glycosylation of clinical phase I anti-melanoma mouse IgG3 monoclonal antibody R24.

21 January 2018

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Different culture methods lead to differences in glycosylation of a murine IgG monoclonal antibody

21 January 2018

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Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells

21 January 2018

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High-throughput immunoglobulin G N-glycan characterization using rapid resolution reverse-phase chromatography tandem mass spectrometry

21 January 2018

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HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software.

21 January 2018

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Biochemistry of growth inhibition by ammonium ions in mammalian cells

21 January 2018

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Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality.

21 January 2018

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Hyperosmotic stress and elevated pCO2 alter monoclonal antibody charge distribution and monosaccharide content

21 January 2018

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Differences in the glycosylation profile of a monoclonal antibody produced by hybridomas cultured in serum-supplemented, serum-free or chemically defined media.

21 January 2018

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Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

21 January 2018

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The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity

21 January 2018

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A comparison of three techniques for quantitative carbohydrate analysis used in characterization of therapeutic antibodies

21 January 2018

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Incorporation of ammonium into intracellular UDP-activated N-acetylhexosamines and into carbohydrate structures in glycoproteins

21 January 2018

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N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG.

21 January 2018

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Rapid production of recombinant human IgG With improved ADCC effector function in a transient expression system

21 January 2018

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An investigation of intracellular glycosylation activities in CHO cells: effects of nucleotide sugar precursor feeding

21 January 2018

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Profiling of N-glycosylation gene expression in CHO cell fed-batch cultures

21 January 2018

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Effect of altered CH2-associated carbohydrate structure on the functional properties and in vivo fate of chimeric mouse-human immunoglobulin G1.

21 January 2018

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Effects of ammonia and glucosamine on the heterogeneity of erythropoietin glycoforms.

21 January 2018

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Development of a simple and rapid method for producing non-fucosylated oligomannose containing antibodies with increased effector function

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.23075

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13 September 2017

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