(Q39599186)

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A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts.

scientific article published on 3 February 2011

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21 January 2020

A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts (English)

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21 January 2020

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21 January 2020

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Deborah S Malley

1

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21 January 2020

Sylvia Kocialkowski

3

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21 January 2020

Danita M Pearson

4

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21 January 2020

Vincent Peter Collins

5

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21 January 2020

Koichi Ichimura

6

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21 January 2020

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3 February 2011

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21 January 2020

Acta Neuropathologica

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21 January 2020

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21 January 2020

5

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21 January 2020

651-661

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21 January 2020

https://scigraph.springernature.com/pub.10.1007/s00401-011-0803-5

0 references

CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Temozolomide versus procarbazine, lomustine, and vincristine in recurrent high-grade glioma.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Relationship between nucleosome positioning and DNA methylation

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Methylation-Related Chromatin Structure Is Associated with Exclusion of Transcription Factors from and Suppressed Expression of the O-6-Methylguanine DNA Methyltransferase Gene in Human Glioma Cell Lines

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

STAT3 regulation of glioblastoma pathogenesis.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

MGMT: its role in cancer aetiology and cancer therapeutics

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Cryopreservation of viable human glioblastoma xenografts.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O6-methylguanine DNA methyltransferase gene

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

The DNA-encoded nucleosome organization of a eukaryotic genome

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Prognostic value of O6-methylguanine-DNA methyltransferase status in glioblastoma patients, assessed by five different methods

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Aberrant silencing of the CpG island-containing human O6-methylguanine DNA methyltransferase gene is associated with the loss of nucleosome-like positioning

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Molecular diagnostics of gliomas: state of the art.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Careful exclusion of non-neoplastic brain components is required for an appropriate evaluation of O6-methylguanine-DNA methyltransferase status in glioma: relationship between immunohistochemistry and methylation analysis.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

What controls nucleosome positions?

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Molecular diagnostics of gliomas: the clinical perspective

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Real-time quantitative polymerase chain reaction (qPCR) analysis with fluorescence resonance energy transfer (FRET) probes reveals differential expression of the four ERBB4 juxtamembrane region variants between medulloblastoma and pilocytic astrocyt

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island.

1 reference

https://api.crossref.org/works/10.1007%2FS00401-011-0803-5

21 January 2018

Identifiers

10.1007/S00401-011-0803-5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21287394%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21287394%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

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