(Q39602947)

13 September 2017

1 reference

title

Valproate-associated hepatotoxicity and its biochemical mechanisms (English)

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13 September 2017

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M J Eadie

1

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13 September 2017

W D Hooper

series ordinal

2

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13 September 2017

R G Dickinson

series ordinal

3

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13 September 2017

1 March 1988

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Medical toxicology and adverse drug experience

13 September 2017

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13 September 2017

3

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13 September 2017

2

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13 September 2017

85-106

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The effect of aspirin on valproic acid metabolism

13 September 2017

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Inhibition by valproic acid of pyruvate uptake by brain mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Decreased serum carnitine in valproate induced Reye syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Mechanism of anticonvulsant action of valproate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Secondary hyperammonaemia: a possible mechanism for valproate encephalopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Rearrangement of valproate glucuronide in a patient with drug-associated hepatobiliary and renal dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Valproic acid hepatic fatalities: a retrospective review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Metabolism of Valproate Sodium in Rabbit, Rat, Dog, and Man

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Reye-like syndrome associated with valproic acid therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Production of the Features of Reye's Syndrome in Rats with 4-Pentenoic Acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Identification of urinary metabolites of sodium dipropylacetate in man; potential sources of interference in organic acid screening procedures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Clinical pharmacokinetics of valproic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Oxidation and glucuronidation of valproic acid in male rats--influence of phenobarbital, 3-methylcholanthrene, beta-naphthoflavone and clofibrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Identification of Metabolites of Valproic Acid in Serum of Humans, Dog, Rat, and Mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

The mechanism of action of sodium valproate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Reduction of the level of the glycine cleavage system in the rat liver resulting from administration of dipropylacetic acid: An experimental approach to hyperglycinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Nutritional influence on serum ammonia in young patients receiving sodium valproate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Serum carnitine during valproic acid therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Valproate-induced hepatic steatogenesis in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Effect of metabolites of valproic acid on the metabolism of GABA in brain and brain nerve endings.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Valproic Acid and Metabolites: Pharmacological and Toxicological Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Hepatotoxicity to sodium valproate: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Valproate hydroxylation by human fetal tissues and embryotoxicity of metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Inhibition of oxidative phosphorylation in hepatic and cerebral mitochondria of sodium valproate-treated rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Effects of anticonvulsant drugs on the cerebral enzymes metabolizing GABA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Propionic acid and dipropylacetic acid in the urine of patients treated with dipropylacetic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Dipropylacetate and aminoaciduria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Sodium di-N-propylacetate (DPA) in the treatment of epilepsy. A review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Carnitine deficiency, organic acidemias, and Reye's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Acute Hepatic Failure Associated with the Use of Sodium Valproate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

A Direct Hepatotoxic Effect of Valproic Acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Valproate causes metabolic disturbance in normal man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

The renal origin of sodium valproate-induced hyperammonemia in fasting humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Sodium valproate-induced hyperammonemia in the rat: role of the kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Effect of valproic acid on hepatic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Acute changes of blood ammonia may predict short-term adverse effects of valproic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03259935

Valproic acid induced pancreatitis in children

21 January 2018

1 reference

12 December 2020

Cytochrome P-450--catalyzed formation of delta 4-VPA, a toxic metabolite of valproic acid

1 reference

12 December 2020

Valproic acid-induced hyperammonemia in mentally retarded adults

1 reference

12 December 2020

Inhibition of the glycine cleavage system: hyperglycinemia and hyperglycinuria caused by valproic acid

1 reference

12 December 2020

Valproate in the treatment of seizures associated with propionic acidemia

1 reference

12 December 2020

Inhibitory effects of sodium valproate on oxidative phosphorylation

1 reference

12 December 2020

On the mechanisms of some pharmacological actions of the hypoglycaemic toxins hypoglycin and pent-4-enoic acid. A way out of the present confusion

1 reference

12 December 2020

Valproic acid and secondary hyperammonemia

1 reference

12 December 2020

pH-dependent rearrangement of the biosynthetic ester glucuronide of valproic acid to beta-glucuronidase-resistant forms

1 reference

12 December 2020

The hepatotoxicity of valproic acid and its metabolites in rats. II. Intermediary and valproic acid metabolism

1 reference

12 December 2020

Influence of valproic acid on hepatic carbohydrate and lipid metabolism

1 reference

12 December 2020

Abnormal metabolism of valproic acid in fatal hepatic failure

1 reference

12 December 2020

[Hepatotoxicity of valproic acid treatment]

1 reference

12 December 2020

Action of the antiepileptic drug, valproic acid, on fatty acid oxidation in isolated rat hepatocytes

1 reference

12 December 2020

Inhibition of fatty acid oxidation by valproate

1 reference

12 December 2020

Enhancement of peroxisomal beta-oxidation in the liver of rats and mice treated with valproic acid

1 reference

12 December 2020

Valproate toxicity and ornithine carbamoyltransferase deficiency

1 reference

12 December 2020

Disposition of valproic acid in the rat: dose-dependent metabolism, distribution, enterohepatic recirculation and choleretic effect

1 reference

12 December 2020

Fatal intoxication with sodium valproate

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12 December 2020

Evidence of inherited urea cycle defect in a case of fatal valproate toxicity

1 reference

12 December 2020

Synthesis and stereochemical determination of diunsaturated valproic acid analogs including its major diunsaturated metabolite

1 reference

12 December 2020

The effects of valproate on intermediary metabolism in isolated rat hepatocytes and intact rats

1 reference

12 December 2020

Concentration of metabolites of valproic acid in plasma of epileptic patients

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12 December 2020

Interaction between valproic acid and aspirin in epileptic children: serum protein binding and metabolic effects

1 reference

12 December 2020

Metabolism of branched medium chain length fatty acid. I. Omega-oxidation of sodium dipropylacetate in rats

1 reference

12 December 2020

Metabolite pattern of valproic acid. Part I: gaschromatographic determination of the valproic acid metabolite artifacts, heptanone-3, 4- and 5-hydroxyvalproic acid lactone

1 reference

12 December 2020

Studies on the urinary excretion of metabolites of valproic acid (dipropylacetic acid) in rats and humans (author's transl)

1 reference

12 December 2020

Metabolism of branched medium chain length fatty acid. II--beta-oxidation of sodium dipropylacetate in rats

1 reference

12 December 2020

Valproate hepatotoxicity: a review and report of two instances in adults

1 reference

12 December 2020

On the toxicity of valproic acid

1 reference

12 December 2020

Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid

1 reference

12 December 2020

The occurrence of C6--C10-dicarboxylic acids in urine from patients and rats treated with dipropylacetate

1 reference

12 December 2020

Carnitine deficiency: a possible mechanism for valproate hepatotoxicity

1 reference

12 December 2020

Valproate-induced inhibition of urea synthesis and hyperammonaemia in healthy subjects

1 reference

12 December 2020

Pancreatitis associated with valproic acid therapy

1 reference

12 December 2020

Metabolism of unsaturated derivatives of valproic acid in rat liver microsomes and destruction of cytochrome P-450.

1 reference

12 December 2020

Increase of human plasma GABA by sodium valproate

1 reference

12 December 2020

Fatal liver failure in children on valproate

1 reference

12 December 2020

Hyperammonemia with valproic acid therapy

1 reference

12 December 2020

Intoxication with sodium valproate. A case report

1 reference

12 December 2020

Aspects of the metabolism of valproic acid

1 reference

12 December 2020

Chronic valproic acid and coantiepileptic drug therapy and incidence of increases in serum liver enzymes

1 reference

12 December 2020

Peroxisomal beta-oxidation and sodium valproate

1 reference

12 December 2020

Heterozygous alpha 1-antitrypsin deficiency and valproate hepatotoxicity

1 reference

12 December 2020

Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry

1 reference

12 December 2020

Altered metabolic profiles of valproic acid in a patient with Reye's syndrome

1 reference

12 December 2020

Valproate-induced hepatic injury: analyses of 23 fatal cases

1 reference

12 December 2020

Pancreatitis due to valproic acid

1 reference

12 December 2020

Effects of valproate on biogenesis and function of liver mitochondria

1 reference

12 December 2020

Studies on the biotransformation in the perfused rat liver of 2-n-propyl-4-pentenoic acid, a metabolite of the antiepileptic drug valproic acid. Evidence for the formation of chemically reactive intermediates

1 reference

12 December 2020

Inhibition of gluconeogenesis by sodium valproate and its metabolites in isolated rat hepatocytes

1 reference

12 December 2020

The hepatotoxicity of valproic acid and its metabolites in rats. I. Toxicologic, biochemical and histopathologic studies

1 reference

12 December 2020

Metabolism of valproic acid by hepatic microsomal cytochrome P-450

1 reference

12 December 2020

Sodium valproate in the induction of unusual hepatotoxicity

1 reference

12 December 2020

Inhibition of mitochondrial fatty acid oxidation in pentenoic acid-induced fatty liver. A possible model for Reye's syndrome

1 reference

12 December 2020

1 reference

12 December 2020

Metabolic fate of valproic acid in the rhesus monkey. Formation of a toxic metabolite, 2-n-propyl-4-pentenoic acid

1 reference

12 December 2020

Biotransformation and pharmacokinetics in the rhesus monkey of 2-n-propyl-4-pentenoic acid, a toxic metabolite of valproic acid

1 reference

12 December 2020

Five doubly unsaturated metabolites of valproic acid in urine and plasma of patients on valproic acid therapy

1 reference

12 December 2020

Valproic acid and several metabolites: quantitative determination in serum, urine, breast milk and tissues by gas chromatography-mass spectrometry using selected ion monitoring

1 reference

12 December 2020

Sodium valproate and ornithine carbamyl transferase deficiency

1 reference

12 December 2020

Effects of dipropylacetate on the glycine cleavage enzyme system and glycine levels. A possible experimental approach to non-ketotic hyperglycinemia.

1 reference

12 December 2020

Carnitine deficiency and hyperammonemia associated with valproic acid therapy

1 reference

12 December 2020

A case of fatal toxic hepatitis: recommendations for the administration of sodium valproate

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF03259935

1 reference

release_7ktyi3jufvdqbivdn7gotxcgym

13 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7ktyi3jufvdqbivdn7gotxcgym

24 November 2022

mapped directly with Wikidata item

1 reference