(Q39613654)

English

Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical

scientific article published on 29 December 2010

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scholarly article

1 reference

Europe PubMed Central

13 September 2017

Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical (English)

1 reference

Europe PubMed Central

13 September 2017

author name string

B M Heath

1

1 reference

Europe PubMed Central

13 September 2017

Y Cui

2

1 reference

Europe PubMed Central

13 September 2017

S Worton

3

1 reference

Europe PubMed Central

13 September 2017

B Lawton

4

1 reference

Europe PubMed Central

13 September 2017

G Ward

5

1 reference

Europe PubMed Central

13 September 2017

E Ballini

6

1 reference

Europe PubMed Central

13 September 2017

C P A Doe

7

1 reference

Europe PubMed Central

13 September 2017

C Ellis

8

1 reference

Europe PubMed Central

13 September 2017

B A Patel

9

1 reference

Europe PubMed Central

13 September 2017

N C McMahon

10

1 reference

Europe PubMed Central

13 September 2017

publication date

29 December 2010

1 reference

Europe PubMed Central

13 September 2017

Journal of Pharmacological and Toxicological Methods

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Europe PubMed Central

13 September 2017

63

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Europe PubMed Central

13 September 2017

3

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Europe PubMed Central

13 September 2017

258-268

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Europe PubMed Central

13 September 2017

Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome

1 reference

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Interactions of flecainide with guinea pig cardiac sodium channels. Importance of activation unblocking to the voltage dependence of recovery

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Conduction disturbances associated with venlafaxine

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Comparatibe actions of mexiletine on sodium channels in nerve, skeletal and cardiac muscle

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Absorption kinetics and pharmacodynamics of two oral dosage forms of flecainide in patients with an episode of paroxysmal atrial fibrillation

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Qrs interval time-related changes and prognosis in heart failure

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Acute electrophysiological effects of flecainide acetate on cardiac conduction and refractoriness in man

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Prognostic value of the QRS duration in patients with heart failure: a subgroup analysis from 24 centers of Val-HeFT.

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Assessment of serum flecainide trough levels in patients with tachyarrhythmia

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Prolonged electrocardiogram QRS duration independently predicts long-term mortality in patients hospitalized for heart failure with preserved systolic function

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Electrocardiogram changes and arrhythmias in venlafaxine overdose

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Clinical characteristics and survival of patients with chronic heart failure and prolonged QRS duration

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The cardiac effects of therapeutic plasma concentrations of imipramine

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Liquid chromatographic determination of unbound flecainide in therapeutic drug monitoring

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Molecular basis for exaggerated sensitivity to mexiletine in the cardiac isoform of the fast Na channel

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Clinical pharmacokinetics of mexiletine

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7 January 2021

Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the 'bad' sodium current blockers

1 reference

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Frequency-independent blockade of cardiac Na+ channels by riluzole: comparison with established anticonvulsants and class I anti-arrhythmics

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Life-threatening diphenhydramine overdose treated with charcoal hemoperfusion and hemodialysis.

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States and sites of actions of flecainide on guinea-pig cardiac sodium channels

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7 January 2021

State-dependent trapping of flecainide in the cardiac sodium channel

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Dolasetron overdose resulting in prolonged QTc interval and severe hypotension: a case report and literature review

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Clinical evaluation of the use-dependent QRS prolongation and the reverse use-dependent QT prolongation of class I and class III antiarrhythmic agents and their value in predicting efficacy.

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The effects of propofol on macroscopic and single channel sodium currents in rat ventricular myocytes

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7 January 2021

Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate

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Congestive heart failure and QRS duration: establishing prognosis study

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Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes

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Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome

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Frequency dependent effects of class I antiarrhythmic agents studied in patients with implanted pacemakers.

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Pharmacokinetics and electrocardiographic effects of a new controlled-release form of flecainide acetate: comparison with the standard form and influence of the CYP2D6 polymorphism

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Tricyclic antidepressants, QT interval prolongation, and torsade de pointes

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Effects of flecainide and quinidine on human atrial action potentials. Role of rate-dependence and comparison with guinea pig, rabbit, and dog tissues

1 reference

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Flecainide: steady state electrophysiologic effects in patients with remote myocardial infarction and inducible sustained ventricular arrhythmia

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Comparative direct electrophysiological effects of propofol on the conduction system and ionic channels of rabbit hearts

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Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations

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Blockage of the sodium current in isolated single cells from rat ventricle with mexiletine and disopyramide.

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Association of QRS duration and outcomes after myocardial infarction: the VALIANT trial

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Resting and rate-dependent depression of maximum rate of depolarisation (Vmax) in guinea pig ventricular action potentials by mexiletine, disopyramide, and encainide.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of Mexiletine on Steady-State Characteristics an Recovery Kinetics of &OV0312;max and Conduction Velocity in Guinea Pig Myocardium

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.12.004

7 January 2021

based on heuristic

inferred from DOI database lookup

Tricyclic antidepressive poisoning with special reference to cardiac complications

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2010.12.004

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.VASCN.2010.12.004

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

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