(Q39623558)

English

Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4.

scientific article published on January 2011

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21132834%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4 (English)

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17 January 2020

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8

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17 January 2020

5

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17 January 2020

Amadeu Llebaria

7

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17 January 2020

Jean-Philippe Pin

6

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17 January 2020

author name string

Christo Christov

1

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17 January 2020

Patricia González-Bulnes

2

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17 January 2020

Fanny Malhaire

3

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17 January 2020

Tatyana Karabencheva

4

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17 January 2020

publication date

1 January 2011

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17 January 2020

1 reference

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17 January 2020

6

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17 January 2020

1

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17 January 2020

131-140

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17 January 2020

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

1 reference

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7 January 2021

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Metabotropic glutamate receptors: physiology, pharmacology, and disease

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Group III metabotropic glutamate-receptor-mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons

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Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain.

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mGluR4-positive allosteric modulation as potential treatment for Parkinson's disease.

1 reference

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7 January 2021

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Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.

1 reference

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7 January 2021

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(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

1 reference

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7 January 2021

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Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

1 reference

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7 January 2021

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Application of electronic circular dichroism in configurational and conformational analysis of organic compounds

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Functional selectivity of GPCR ligand stereoisomers: new pharmacological opportunities

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7 January 2021

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Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes

1 reference

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7 January 2021

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Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000378

7 January 2021

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Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).

1 reference

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7 January 2021

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An alkaloid-mediated desymmetrization of meso-anhydrides via a nucleophilic ring opening with benzyl alcohol and its application in the synthesis of highly enantiomerically enriched β-amino acids

1 reference

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7 January 2021

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Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000378

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

1 reference

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7 January 2021

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N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors

1 reference

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7 January 2021

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Conformational pathways of saturated six-membered rings. A static and dynamical density functional study

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7 January 2021

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Synchrotron radiation circular dichroism spectroscopy-defined structure of the C-terminal domain of NaChBac and its role in channel assembly

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7 January 2021

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Optically active oxo(phthalocyaninato)vanadium(IV) with geometric asymmetry: synthesis and correlation between the circular dichroism sign and conformation

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7 January 2021

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Thermodynamics of nucleotide and inhibitor binding to wild-type and ispinesib-resistant forms of human kinesin spindle protein

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Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation

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7 January 2021

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Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange

1 reference

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7 January 2021

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Ligand binding and micro-switches in 7TM receptor structures

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7 January 2021

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Computational mapping of the conformational transitions in agonist selective pathways of a G-protein coupled receptor.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201000378

7 January 2021

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Structure and function of G protein-coupled receptors using NMR spectroscopy

1 reference

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7 January 2021

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Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

1 reference

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7 January 2021

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Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.

1 reference

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Ab initio quantum chemistry: methodology and applications

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Density-functional thermochemistry. III. The role of exact exchange

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Note on an Approximation Treatment for Many-Electron Systems

1 reference

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7 January 2021

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Quantum mechanical continuum solvation models.

1 reference

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7 January 2021

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Single-reference ab initio methods for the calculation of excited states of large molecules

1 reference

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7 January 2021

based on heuristic

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Identifiers

10.1002/CMDC.201000378

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21132834%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21132834%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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