(Q39638086)

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A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells.

scientific article published on 29 October 2010

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15 January 2020

A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells (English)

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15 January 2020

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Seung Bae Rho

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Boh-Ram Kim

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29 October 2010

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15 January 2020

Gynecologic Oncology

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121-127

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15 January 2020

Cancer statistics, 2005

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Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway

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AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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Signaling by distinct classes of phosphoinositide 3-kinases

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PIK3CA mutations in advanced ovarian carcinomas

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PIK3CA is implicated as an oncogene in ovarian cancer.

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Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

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PIK3CA mutations in ovarian cancer.

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Prognostic value of PIK3CA and phosphorylated AKT expression in ovarian cancer

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PIK3CA amplification associates with resistance to chemotherapy in ovarian cancer patients.

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A combined biochemical and cytogenetic study of thioridazine-induced damage to nucleic acids

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Thioridazine interacts with the membrane of mitochondria acquiring antioxidant activity toward apoptosis--potentially implicated mechanisms.

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Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors.

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Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

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Phosphatidylinositol 3-kinase mediates angiogenesis and vascular permeability associated with ovarian carcinoma

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RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model

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mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary

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Antiproliferative effects of rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines

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Identifiers

10.1016/J.YGYNO.2010.10.003

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21035837%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

Europe PubMed Central

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15 January 2020

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