(Q39640187)

13 September 2017

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title

Nobel lecture in physiology or medicine--1987. Somatic generation of immune diversity (English)

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13 September 2017

S Tonegawa

1

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13 September 2017

publication date

1 April 1988

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In Vitro Cellular & Developmental Biology

13 September 2017

published in

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13 September 2017

volume

24

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13 September 2017

issue

4

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13 September 2017

page(s)

253-265

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Molecular hybridization of ribonucleic acid with a large excess of deoxyribonucleic acid

13 September 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FBF02628825

Organization and expression of immunoglobulin genes in fetal liver hybridomas

21 January 2018

1 reference

12 December 2020

Exon shuffling generates an immunoglobulin heavy chain gene

1 reference

12 December 2020

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1 reference

12 December 2020

The molecular basis of antibody formation: a paradox

1 reference

12 December 2020

A third type of murine T-cell receptor gene

1 reference

12 December 2020

OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties.

1 reference

12 December 2020

Major histocompatibility complex-linked specificity of γδ receptor-bearing T lymphocytes

1 reference

12 December 2020

Expression of the T-cell receptor gamma-chain gene products on the surface of peripheral T cells and T-cell blasts generated by allogeneic mixed lymphocyte reaction

1 reference

12 December 2020

The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer

1 reference

12 December 2020

Cloning of an immunoglobulin variable region gene from mouse embryo

1 reference

12 December 2020

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

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12 December 2020

Identification of a putative second T-cell receptor.

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12 December 2020

Immunoglobulin gene rearrangement in immature B cells

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12 December 2020

Identification of a T3-associated gamma delta T cell receptor on Thy-1+ dendritic epidermal Cell lines

1 reference

12 December 2020

Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes.

1 reference

12 December 2020

A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

1 reference

12 December 2020

A one and a half receptor model for MHC-restricted antigen recognition by T lymphocytes

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12 December 2020

A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes

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12 December 2020

Mechanism of antibody diversity: germ line basis for variability

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12 December 2020

VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSE

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12 December 2020

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

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12 December 2020

Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes.

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12 December 2020

Transfer of specificity by murine alpha and beta T-cell receptor genes

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12 December 2020

Differential expression of two distinct T-cell receptors during thymocyte development

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12 December 2020

A functional γ gene formed from known γ-gene segments is not necessary for antigen-specific responses of murine cytotoxic T lymphocytes

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12 December 2020

Diversity of germ-line immunoglobulin VH genes.

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12 December 2020

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.

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12 December 2020

Diversity at the variable-joining region boundary of lambda light chains has a pronounced effect on immunoglobulin ligand-binding activity

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12 December 2020

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12 December 2020

The somatic generation of immune recognition

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12 December 2020

Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes

1 reference

12 December 2020

Regulation of T-cell receptor gamma-chain RNA expression in murine Thy-1+ dendritic epidermal cells

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12 December 2020

DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats

1 reference

12 December 2020

Limited diversity of the rearranged T-cell gamma gene.

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12 December 2020

Unusual organization and diversity of T-cell receptor alpha-chain genes.

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12 December 2020

Identification of a DNA binding protein that recognizes the nonamer recombinational signal sequence of immunoglobulin genes.

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12 December 2020

Variability in the Lambda Light Chain Sequences of Mouse Antibody

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12 December 2020

Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor

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12 December 2020

A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody.

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12 December 2020

An immunoglobulin heavy-chain gene is formed by at least two recombinational events

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12 December 2020

Amino acid sequence studies with Bence-Jones proteins

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12 December 2020

Three-dimensional structure of an antigen-antibody complex at 2.8 A resolution

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12 December 2020

Hybridization of RNA to double-stranded DNA: formation of R-loops

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12 December 2020

T-cell gamma gene is allelically but not isotypically excluded and is not required in known functional T-cell subsets

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12 December 2020

Sets of immunoglobulin V kappa genes homologous to ten cloned V kappa sequences: implications for the number of germline V kappa genes

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12 December 2020

Somatic evolution of variable region structures during an immune response

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12 December 2020

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

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12 December 2020

Antibody diversity: somatic hypermutation of rearranged VH genes

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12 December 2020

A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes

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12 December 2020

Studies of simian virus 40 DNA. VII. A cleavage map of the SV40 genome

1 reference

12 December 2020

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12 December 2020

Variable and constant parts of the immunoglobulin light chain gene of a mouse myeloma cell are 1250 nontranslated bases apart

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12 December 2020

Developmental regulation of T-cell receptor gene expression

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12 December 2020

Demonstration that IgG memory is carried by IgG-bearing cells

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12 December 2020

Detection of specific sequences among DNA fragments separated by gel electrophoresis

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12 December 2020

A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes

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12 December 2020

Structure, organization, and somatic rearrangement of T cell gamma genes.

1 reference

12 December 2020

Somatic recombination in a murine T-cell receptor gene

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12 December 2020

Regulated progression of a cultured pre-B-cell line to the B-cell stage.

1 reference

12 December 2020

Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody

1 reference

12 December 2020

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody

1 reference

12 December 2020

Reiteration frequency of immunoglobulin light chain genes: further evidence for somatic generation of antibody diversity

1 reference

12 December 2020

Factors affecting the propagation of a B cell clone forming antibody to the 2,4-dinitrophenyl group.

1 reference

12 December 2020

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene

1 reference

12 December 2020

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

1 reference

12 December 2020

Molecular events during maturation of the immune response to oxazolone

1 reference

12 December 2020

No functional gamma-chain transcripts detected in an alloreactive cytotoxic T-cell clone

1 reference

12 December 2020

Transcription of nonrepeated DNA in neonatal and fetal mice

1 reference

12 December 2020

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1 reference

12 December 2020

Antibody Structure and Molecular Immunology

1 reference

12 December 2020

Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism

1 reference

12 December 2020

A γ-chain complex forms a functional receptor on cloned human lymphocytes with natural killer-like activity

1 reference

12 December 2020

T gamma protein is expressed on murine fetal thymocytes as a disulphide-linked heterodimer.

1 reference

12 December 2020

Molecular anatomy of the antibody binding site

1 reference

12 December 2020

A complete immunoglobulin gene is created by somatic recombination

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12 December 2020

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences.

1 reference

12 December 2020

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions

1 reference

12 December 2020

Structural studies of immunoglobulins

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12 December 2020

Immunoglobulin-like nature of the α-chain of a human T-cell antigen/MHC receptor

1 reference

12 December 2020

Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A

1 reference

12 December 2020

Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain

1 reference

12 December 2020

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH.

1 reference

12 December 2020

The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor

1 reference

12 December 2020

Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes

1 reference

12 December 2020

Genomic organization of the genes encoding mouse T-cell receptor alpha-chain.

1 reference

12 December 2020

Rearrangement of genetic information may produce immunoglobulin diversity

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12 December 2020

Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions

1 reference

12 December 2020

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin

1 reference

12 December 2020

Purification and NH2-terminal amino acid sequencing of the beta subunit of a human T-cell antigen receptor

1 reference

12 December 2020

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions

1 reference

12 December 2020

Three-dimensional structure of an antibody-antigen complex

1 reference

12 December 2020

H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;

1 reference

12 December 2020

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes.

1 reference

12 December 2020

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.

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12 December 2020

Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.

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12 December 2020

Mapping of immunoglobulin variable region genes: relationship to the 'deletion' model of immunoglobulin gene rearrangement

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12 December 2020

Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses.

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12 December 2020

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments

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12 December 2020

Identifiers

DOI

10.1007/BF02628825

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13 September 2017

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