(Q39652589)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20861921%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells (English)

1 reference

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14 February 2020

0 references

1 reference

chronic lymphocytic leukemia

1 reference

6

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14 February 2020

author name string

M Suljagic

1

1 reference

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14 February 2020

L Laurenti

2

1 reference

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14 February 2020

M Tarnani

3

1 reference

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14 February 2020

M Alam

4

1 reference

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14 February 2020

S N Malek

5

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14 February 2020

publication date

23 September 2010

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14 February 2020

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14 February 2020

volume

24

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14 February 2020

issue

12

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14 February 2020

page(s)

2063-2071

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Recent advances in the molecular biology and immunobiology of chronic lymphocytic leukemia.

14 February 2020

cites work

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Lysophosphatidic acid (LPA) protects primary chronic lymphocytic leukemia cells from apoptosis through LPA receptor activation of the anti-apoptotic protein AKT/PKB.

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

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PHLiPPing the switch on Akt and protein kinase C signaling

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The phosphatase PHLPP controls the cellular levels of protein kinase C

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Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway

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Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms

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Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory

21 January 2018

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beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.

21 January 2018

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7 January 2021

Identifiers

DOI

10.1038/LEU.2010.201

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20861921%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference