(Q39659292)

13 September 2017

PRIMA-1(MET)/APR-246 targets mutant forms of p53 family members p63 and p73. (English)

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13 September 2017

N Rökaeus

1

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13 September 2017

J Shen

2

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13 September 2017

I Eckhardt

3

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13 September 2017

V J N Bykov

4

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13 September 2017

K G Wiman

5

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13 September 2017

M T Wilhelm

6

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13 September 2017

language of work or name

English

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publication date

6 September 2010

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13 September 2017

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13 September 2017

29

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13 September 2017

49

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13 September 2017

6442-6451

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https://scigraph.springernature.com/pub.10.1038/onc.2010.382

13 September 2017

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cites work

p63-associated disorders.

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https://api.crossref.org/works/10.1038%2FONC.2010.382

Structural basis for gene activation by p53 family members

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.382

The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.382

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.382

PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

p53 family members in myogenic differentiation and rhabdomyosarcoma development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

How many mutant p53 molecules are needed to inactivate a tetramer?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

PML is a direct p53 target that modulates p53 effector functions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Regulation of p53 activity in nuclear bodies by a specific PML isoform

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

p73β-Mediated Apoptosis Requires p57kip2Induction and IEX-1 Inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

TAp63 induces senescence and suppresses tumorigenesis in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

p63 is a p53 homologue required for limb and epidermal morphogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

The IARC TP53 database: new online mutation analysis and recommendations to users

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Temperature-sensitive mutants of p53 homologs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

PRIMA-1(MET) induces nucleolar accumulation of mutant p53 and PML nuclear body-associated proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

A novel protein with strong homology to the tumor suppressor p53.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

From p63 to p53 across p73.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

TAp63 prevents premature aging by promoting adult stem cell maintenance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

p63 protects the female germ line during meiotic arrest

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

A new human p53 homologue

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

New p73 variants with altered C-terminal structures have varied transcriptional activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

Live or let die: the cell's response to p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.382

NBP is the p53 homolog p63.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.382

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.382

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Dimensions Publication ID

13 September 2017

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