(Q39660439)

English

Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1.

scientific article published on January 2011

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scholarly article

1 reference

Europe PubMed Central

13 September 2017

Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. (English)

1 reference

Europe PubMed Central

13 September 2017

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

Ramesh M Ray

1

1 reference

Europe PubMed Central

13 September 2017

Sujoy Bhattacharya

2

1 reference

Europe PubMed Central

13 September 2017

Leonard R Johnson

3

1 reference

Europe PubMed Central

13 September 2017

publication date

1 January 2011

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

16

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Europe PubMed Central

13 September 2017

35-44

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Europe PubMed Central

13 September 2017

1

1 reference

Europe PubMed Central

13 September 2017

https://scigraph.springernature.com/pub.10.1007/s10495-010-0538-0

0 references

p53 mutations in human cancers

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

TP53 family members and human cancers

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Regulation of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

On the shoulders of giants: p63, p73 and the rise of p53.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Regulating the p53 system through ubiquitination

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Identification and classification of p53-regulated genes

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D1, and p16INK4A and is a region of low proliferation

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Structural basis for gene activation by p53 family members

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

p73, a sophisticated p53 family member in the cancer world

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Polyamines are required for activation of c-Jun NH2-terminal kinase and apoptosis in response to TNF-alpha in IEC-6 cells

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

What we could do now: molecular pathology of colorectal cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Role of the p53-homologue p73 in E2F1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Apaf-1 is a mediator of E2F-1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Role for the p53 homologue p73 in E2F-1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Cellular effects of CPT-11 on colon carcinoma cells: dependence on p53 and hMLH1 status

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Mdm2: keeping p53 under control

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Regulating p73 isoforms in human tumours

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

p73: Friend or foe in tumorigenesis

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

E2F target genes: unraveling the biology

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Regulation of the p73 protein stability and degradation

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Involvement of E2F transcription factor family in cancer

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Gene expression analysis in colorectal cancer using practical DNA array filter

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome

1 reference

https://api.crossref.org/works/10.1007%2FS10495-010-0538-0

21 January 2018

Identifiers

10.1007/S10495-010-0538-0

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

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