(Q39662377)

13 September 2017

1 reference

title

Protein binding as a primary determinant of the clinical pharmacokinetic properties of non-steroidal anti-inflammatory drugs (English)

1 reference

13 September 2017

0 references

1 reference

J H Lin

1

1 reference

13 September 2017

D M Cocchetto

series ordinal

2

1 reference

13 September 2017

D E Duggan

series ordinal

3

1 reference

13 September 2017

1 June 1987

1 reference

Clinical Pharmacokinetics

13 September 2017

1 reference

13 September 2017

12

1 reference

13 September 2017

402-432

1 reference

13 September 2017

6

1 reference

https://scigraph.springernature.com/pub.10.2165/00003088-198712060-00002

13 September 2017

0 references

cites work

The interactions of drugs and plasma proteins.

1 reference

12 December 2020

Administration of heparin causes release of non-esterified fatty acids in human plasma

1 reference

12 December 2020

Interaction between azapropazone and warfarin

1 reference

12 December 2020

Piroxicam: a review of its pharmacological properties and therapeutic efficacy

1 reference

12 December 2020

Comparison of tissue fluid and plasma concentrations of a protein-bound drug sulphormethoxine by in vivo dialysis in rats

1 reference

12 December 2020

A phenylbutazone dose-finding study in rheumatoid arthritis

1 reference

12 December 2020

Non-steroidal anti-inflammatory drugs. Current status and rational therapeutic use.

1 reference

12 December 2020

Diseases and Drug Protein Binding

1 reference

12 December 2020

Kinetics of salicylate elimination by anephric patients

1 reference

12 December 2020

Effect of saturable binding on the pharmacokinetics of drugs: a simulation

1 reference

12 December 2020

Distribution and excretion of four tetracycline analogues in normal young men

1 reference

12 December 2020

Indomethacin in rheumatoid arthritis: clinical effects, pharmacokinetics, and platelet studies in responders and nonresponders

1 reference

12 December 2020

Pharmacokinetic implications of stereoselective changes in plasma-protein binding: warfarin/sulfinpyrazone

1 reference

12 December 2020

Effect of initial conditions and drug-protein binding on the time to equilibrium in dialysis systems

1 reference

12 December 2020

Protein-binding of small molecules: new gel filtration method

1 reference

12 December 2020

Plasma protein binding and distribution characteristics of drugs as indices of their hemodialyzability

1 reference

12 December 2020

Plasma protein binding and interaction studies with diflunisal, a new salicylate analgesic

1 reference

12 December 2020

Pharmacokinetics of drugs in patients with the nephrotic syndrome

1 reference

12 December 2020

Kinetics of drug displacement interactions

1 reference

12 December 2020

Factors affecting the serum protein binding of salicylic acid in newborn infants and their mothers.

1 reference

12 December 2020

Pharmacokinetics of naproxen overdoses

1 reference

12 December 2020

Plasma concentrations and therapeutic effect of anti-inflammatory and anti-rheumatic drugs

1 reference

12 December 2020

Respiratory gases of synovial fluids. An approach to synovial tissue circulatory-metabolic imbalance in rheumatoid arthritis

1 reference

12 December 2020

Calculation of drug concentration in plasma after equilibrium dialysis

1 reference

12 December 2020

Drug protein binding and the nephrotic syndrome

1 reference

12 December 2020

Evaluation of methods to determine protein-binding of drugs. Equilibrium dialysis, ultrafiltration, ultracentrifugation, gel filtration

1 reference

12 December 2020

New Peripherally-Acting Oral Analgesic Agents

1 reference

12 December 2020

The binding of drugs by plasma proteins

1 reference

12 December 2020

Pharmacokinetics and Metabolism of the Anti-Inflammatory Agent Voltaren

1 reference

12 December 2020

Ketoprofen-aspirin interactions

1 reference

12 December 2020

Protein binding of tolmetin

1 reference

12 December 2020

Stereoselective disposition of ibuprofen enantiomers in man

1 reference

12 December 2020

Interaction between azapropazone and warfarin

1 reference

12 December 2020

Role of concentration-dependent plasma protein binding in disopyramide disposition

1 reference

12 December 2020

Further characterization of specific drug binding sites on human serum albumin

1 reference

12 December 2020

Interaction of several coumarin compounds with human and canine plasma albumin

1 reference

12 December 2020

Diflunisal: a review of pharmacokinetic and pharmacodynamic properties, drug interactions, and special tolerability studies in humans

1 reference

12 December 2020

Identification and quantification of proteins, glycoproteins and lipoproteins of cerebrospinal fluid

1 reference

12 December 2020

Effect of naproxen on the kinetics of elimination and anticoagulant activity of a single dose or warfarin

1 reference

12 December 2020

Factors affecting drug binding in plasma of elderly patients

1 reference

12 December 2020

Factors affecting drug metabolism

1 reference

12 December 2020

Observations on the antirheumatic and physiologic effects of phenylbutazone (butazolidin) and some comparisons with cortisone

1 reference

12 December 2020

Influence of acute renal failure on the protein binding of drugs in animals and in man

1 reference

12 December 2020

Distribution of salicylate between neonatal and maternal serum at diffusion equilibrium

1 reference

12 December 2020

Hepatic toxicity of nonsteroidal anti-inflammatory drugs

1 reference

12 December 2020

Anti-inflammatory analgesic drug responders and non-responders: a clinico-pharmacological study of flurbiprofen

1 reference

12 December 2020

The displacement of phenylbutazone-14C and warfarin-14C from human albumin by various drugs and fatty acids

1 reference

12 December 2020

Disposition of azapropazone in chronic renal and hepatic failure

1 reference

12 December 2020

The use of antipyrine in the measurement of total body water in man

1 reference

12 December 2020

Protein binding of salicylate in uremic and normal plasma

1 reference

12 December 2020

Protein binding of drugs in plasma from patients with acute renal failure.

1 reference

12 December 2020

Albumin metabolism in rheumatoid arthritis

1 reference

12 December 2020

Potentiation of anticoagulant effect of warfarin by phenylbutazone

1 reference

12 December 2020

The Passage of Benorylate Into the Synovial Fluid and Tissue of Rheumatoid Patients

1 reference

12 December 2020

Linear and nonlinear assessment of tolmetin pharmacokinetics

1 reference

12 December 2020

Variations of serum concentrations and half-life of salicylate in patients with rheumatoid arthritis

1 reference

12 December 2020

Albumin binding of anti-inflammatory drugs. Utility of a site-oriented versus a stoichiometric analysis.

1 reference

12 December 2020

The distribution of immunoglobulins and albumin between maternal and cord serum at delivery

1 reference

12 December 2020

Pharmacokinetics and biochemical effects in responders and non-responders to non-steroidal anti-inflammatory drugs.

1 reference

12 December 2020

Effect of heparin or salicylate infusion on serum protein binding and on concentrations of phenytoin in serum, brain and cerebrospinal fluid of rats

1 reference

12 December 2020

Transynovial exchange of small molecules in normal human subjects.

1 reference

12 December 2020

Synovial permeability in rheumatoid arthritis

1 reference

12 December 2020

Blood Levels of Drug at the Equilibrium State after Multiple Dosing

1 reference

12 December 2020

Interactions of anti-rheumatic drugs

1 reference

12 December 2020

Physiological disposition of fenoprofen in man. 3. Metabolism and protein binding of fenoprofen

1 reference

12 December 2020

Pharmacokinetics of ibuprofen in man--III: Plasma protein binding.

1 reference

12 December 2020

Interaction between diflunisal and warfarin

1 reference

12 December 2020

Influence of disease on binding of drugs to plasma proteins

1 reference

12 December 2020

Binding of Drugs by Albumin Plasma Protein

1 reference

12 December 2020

Possible mechanisms for reduced plasma clearance of diflunisal in rat experimental renal failure

1 reference

12 December 2020

Free fraction change with differing volume ratios in equilibrium dialysis: cases of non-linear drug-protein binding

1 reference

12 December 2020

Salicylate clearance, the resultant of protein binding and metabolism

1 reference

12 December 2020

Dynamic Dialysis as a Method for Studying Protein Binding II: Evaluation of the Method with a Number of Binding Systems

1 reference

12 December 2020

Serum Concentrations of Free Diphenylhydantoin and their Relationship To Clinical Intoxication

1 reference

12 December 2020

Permeability of human synovial membrane to plasma proteins. Relationship to molecular size and inflammation.

1 reference

12 December 2020

Factors determining efficacy of NSAIDs

1 reference

12 December 2020

What is interstitial fluid? Biochemical and physiological analysis of fluid obtained from tissue cages

1 reference

12 December 2020

Protein binding of indomethacin: binding of indomethacin to human plasma albumin and its displacement from binding by ibuprofen, phenylbutazone and salicylate, in vitro

1 reference

12 December 2020

Dose-dependent pharmacokinetics of diflunisal in rats: dual effects of protein binding and metabolism.

1 reference

12 December 2020

Removal of fatty acids from serum albumin by charcoal treatment

1 reference

12 December 2020

[Inter- and intra-individual variations on the disposition of piroxicam. Pharmacokinetics in healthy man and the patient with renal insufficiency]

1 reference

12 December 2020

Characterization of salicylate binding to synovial fluid and plasma protein in patients with rheumatoid arthritis

1 reference

12 December 2020

Flurbiprofen at night

1 reference

12 December 2020

A rapid method for the determination of salicylate binding by the use of ultrafilters.

1 reference

12 December 2020

Optical studies of drug-protein complexes. II. Interaction of phenylbutazone and its analogues with human serum albumin

1 reference

12 December 2020

Double-blind dose-response study of indomethacin in rheumatoid arthritis

1 reference

12 December 2020

Indomethacin in rheumatoid arthritis: comparison of oral and rectal dosing

1 reference

12 December 2020

Drug disposition and pharmacokinetics in the maternal-placental-fetal unit

1 reference

12 December 2020

Relationship of serum naproxen concentration to efficacy in rheumatoid arthritis

1 reference

12 December 2020

Influence of volume shifts on drug binding during equilibrium dialysis: correction and attenuation.

1 reference

12 December 2020

Effect of plasma protein binding on the anticoagulant action of warfarin in rats

1 reference

12 December 2020

Pharmacokinetics of Carprofen in Plasma and Synovial Fluid

1 reference

12 December 2020

Plasma volume changes as a result of equilibrium dialysis

1 reference

12 December 2020

Representation and interpretation of drug displacement interactions

1 reference

12 December 2020

Protein binding and hepatic clearance: studies with tolbutamide, a drug of low intrinsic clearance, in the isolated perfused rat liver preparation

1 reference

12 December 2020

Clinical Pharmacokinetics of Non-steroidal Anti-inflammatory Drugs

1 reference

12 December 2020

Commentary: a physiological approach to hepatic drug clearance

1 reference

12 December 2020

The Disposition and Metabolism of Flurbiprofen in Several Species Including Man

1 reference

12 December 2020

Absorption and excretion of tolmetin in arthritic patients

1 reference

12 December 2020

A MICRO METHOD FOR ANALYSIS OF PLASMA SALICYLATE

1 reference

12 December 2020

A concept of negative interstitial pressure based on pressures in implanted perforated capsules

1 reference

12 December 2020

Correction of protein binding defect in uremic sera by charcoal treatment

1 reference

12 December 2020

The binding of three penicillins in the plasma of several mammalian species as studied by ultrafiltration at body temperature

1 reference

12 December 2020

Anion transport from the canine synovial cavity.

1 reference

12 December 2020

The characterization of two specific drug binding sites on human serum albumin

1 reference

12 December 2020

Ultrafiltration in serum protein binding determinations.

1 reference

12 December 2020

Clinical pharmacokinetics of cerebrospinal fluid

1 reference

12 December 2020

Effects of plasma protein binding of drugs on duration and intensity of pharmacological activity

1 reference

12 December 2020

Diphenylhydantoin potency and plasma protein binding

1 reference

12 December 2020

Drug-protein binding: recent advances in methodology: spectroscopic techniques

1 reference

12 December 2020

Protein binding displacement interactions and their clinical importance

1 reference

12 December 2020

Absorption and excretion of tolmetin in man

1 reference

12 December 2020

Interaction of sulindac and metabolite with human serum albumin

1 reference

12 December 2020

Bioavailability of naproxen sodium and its relationship to clinical analgesic effects

1 reference

12 December 2020

Effect of serum protein binding on pharmacokinetics and anticoagulant activity of phenprocoumon in rats

1 reference

12 December 2020

Factors affecting the intraocular penetration of antibiotics. The influence of route, inflammation, animal species and tissue pigmentation

1 reference

12 December 2020

Membrane ultrafiltration: The diafiltration technique and its application to microsolute exchange and binding phenomena

1 reference

12 December 2020

Pharmacokinetics of indomethacin in the neonate. Relation of plasma indomethacin levels to response of the ductus arteriosus

1 reference

12 December 2020

Clearance concepts in pharmacokinetics

1 reference

12 December 2020

The influence of age on the activity of acetylsalicylic acid-esterase and protein-salicylate binding.

1 reference

12 December 2020

Effect of nonlinear protein binding on equilibration times for different initial conditions

1 reference

12 December 2020

Altered plasma albumin in the newborn infant

1 reference

12 December 2020

Effect of Plasma Protein Binding on Elimination of Warfarin

1 reference

12 December 2020

Binding of nonsteroidal anti-inflammatory agents to proteins—I. Ibuprofen-serum albumin interaction

1 reference

12 December 2020

Synovial fine structure and permeability after intra-articular nitrogen mustard

1 reference

12 December 2020

The binding of organic ions by proteins.

1 reference

12 December 2020

Combination use of nonsteroidal antiinflammatory drugs

1 reference

12 December 2020

Concepts basic to pharmacokinetics

1 reference

12 December 2020

Pharmacokinetics of azapropazone following single oral and intravenous doses

1 reference

12 December 2020

Binding of indomethacin to human serum albumin. Its non displacement by various agents, influence of free fatty acids and the unexpected effect of indomethacin on warfarin binding

1 reference

12 December 2020

Effect of uremia and anephric state on the pharmacokinetics of sulindac and its metabolites in rats. I. An application of pharmacokinetic model for reversible metabolism

1 reference

12 December 2020

Study of drug-protein binding by affinity chromatography: interaction of bovine serum albumin and salicylic acid

1 reference

12 December 2020

Albumin catabolism in burns and following surgical procedures

1 reference

12 December 2020

Serum protein binding of drugs during and after pregnancy in humans.

1 reference

12 December 2020

Measurement of clinical response to anti-inflammatory drug therapy in rheumatoid arthritis

1 reference

12 December 2020

The specific binding of L-tryptophan to serum albumin

1 reference

12 December 2020

Relationship between renal clearance, protein binding and urine flow for digitoxin, a compound of low clearance in the isolated perfused rat kidney

1 reference

12 December 2020

Simultaneous pharmacokinetics of indomethacin in serum and synovial fluid

1 reference

12 December 2020

Binding of piroxicam to synovial fluid and plasma proteins in patients with rheumatoid arthritis

1 reference

12 December 2020

Failure of Indomethacin and Warfarin to Interact in Normal Human Volunteers

1 reference

12 December 2020

Displacement of albumin-bound warfarin by anti-inflammatory agents in vitro

1 reference

12 December 2020

Comparative steady state pharmacokinetic study of piroxicam and flurbiprofen in normal subjects

1 reference

12 December 2020

An in vitro study of drug displacement interactions: warfarin-salicylate and warfarin-phenylbutazone

1 reference

12 December 2020

Plasma protein binding and therapeutic drug monitoring

1 reference

12 December 2020

Stereoselective interaction of phenylbutazone with [12C/13C]warfarin pseudoracemates in man

1 reference

12 December 2020

Microultrafiltration technique for drug-protein binding determination in plasma

1 reference

12 December 2020

A circular dichroic investigation of the binding of fenoprofen, 2(3-phenoxyphenyl)-propionic acid, to human serum albumin

1 reference

12 December 2020

Investigation of phenylbutazone in synovial fluid

1 reference

12 December 2020

Protein Binding and Kinetics of Drugs in Liver Diseases

1 reference

12 December 2020

The measurement of binding constants using circular dichroism. Binding of phenylbutazone and oxyphenbutazone

1 reference

12 December 2020

Drug interactions with warfarin

1 reference

12 December 2020

Binding of drugs to tissues

1 reference

12 December 2020

Effects of change in elimination on varous parameters of the two-compartment open model.

1 reference

12 December 2020

Dynamic dialysis as a method for studying protein binding. I. Factors affecting the kinetics of dialysis through a cellophane membrane

1 reference

12 December 2020

Plasma concentration of phenylbutazone and its therapeutic effect-studies in patients with rheumatoid arthritis

1 reference

12 December 2020

[Serum concentrations of piroxicam in relation to clinical effectiveness in patients with chronic polyarthritis]

1 reference

12 December 2020

Protein binding of some non-steroidal anti-inflammatory drugs in rheumatoid arthritis

1 reference

12 December 2020

Alteration of plasma albumin in relation to decreased drug binding in uremia

1 reference

12 December 2020

Protein binding of drugs in uremic and normal serum: the role of endogenous binding inhibitors

1 reference

12 December 2020

Plasma and Tissue Binding Considerations in Drug Disposition

1 reference

12 December 2020

Furosemide binding to human albumin and plasma of nephrotic children

1 reference

12 December 2020

Pharmacokinetics of naproxen in subjects with normal and impaired renal function

1 reference

12 December 2020

Antirheumatic drug concentrations in human synovial fluid and synovial tissue. Observations on extravascular pharmacokinetics

1 reference

12 December 2020

Plasma binding and the affinity of propranolol for a beta receptor in man

1 reference

12 December 2020

1 reference

12 December 2020

Effect of Altered Plasma Protein Binding on Apparent Volume of Distribution

1 reference

12 December 2020

Protein interactions of sulfonylurea compounds

1 reference

12 December 2020

Metabolic and pharmacokinetic studies with fenbufen in man.

1 reference

12 December 2020

Experimental Osteoarthritis in the Rabbit:A Study of133Xenon Washout Rates from the Synovial Cavity

1 reference

12 December 2020

The relation between the binding of sulfonamides to albumin and their antibacterial efficacy

1 reference

12 December 2020

The binding of catecholamines to human serum proteins

1 reference

12 December 2020

Alternative models for the analysis of drug-protein binding

1 reference

12 December 2020

A comparison of in vitro and in vivo solute-protein binding interactions in normal and uremic subjects.

1 reference

12 December 2020

Plasma and synovial fluid concentrations of acetylsalicylic acid in patients with rheumatoid arthritis

1 reference

12 December 2020

Warfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazone

1 reference

12 December 2020

Binding of diffusible molecules by macromolecules: rapid measurement by rate of dialysis

1 reference

12 December 2020

Plasma and tissue protein binding of drugs in pharmacokinetics

1 reference

12 December 2020

[Determination of the binding of sulfonamides to serum proteins with the ultracentrifuge.]

1 reference

12 December 2020

Biotransformation of diflunisal and renal excretion of its glucuronides in renal insufficiency

1 reference

12 December 2020

Amino acid composition of serum albumin in normal individuals and in patients with rheumatoid arthritis

1 reference

12 December 2020

Errors in interpretation of data from equilibrium dialysis protein binding experiments

1 reference

12 December 2020

Nonlinear plasma level response to high doses of naproxen

1 reference

12 December 2020

Aspirin survival in human blood modulated by the concentration of erythrocytes

1 reference

12 December 2020

Low urea-nitrogen and elevated serum albumin in anxiety, neuroses and psychoses

1 reference

12 December 2020

Simultaneous pharmacokinetics of alclofenac in plasma and synovial fluid in patients with rheumatoid arthritis

1 reference

12 December 2020

Influence of binding on the pharmacologic activity of antibiotics

1 reference

12 December 2020

Anti-inflammatory Agents in the Treatment of the Rheumatic Disorders

1 reference

12 December 2020

Binding of drugs to human serum albumin:XI. The specificity of three binding sites as studied with albumin immobilized in microparticles

1 reference

12 December 2020

The tissue cage model in the distribution of antibacterial agents

1 reference

12 December 2020

Measurement of protein-binding phenomena by gel filtration

1 reference

12 December 2020

Ibuprofen levels in serum and synovial fluid

1 reference

12 December 2020

Influence of chronic renal failure and hemodialysis on diflunisal plasma protein binding

1 reference

12 December 2020

1 reference

12 December 2020

Techniques for plasma protein binding of demethylchlorimipramine

1 reference

12 December 2020

10.2165/00003088-198712060-00002

Identifiers

DOI

1 reference

Dimensions Publication ID

13 September 2017

0 references

1 reference