(Q39665082)

13 September 2017

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title

Activation mechanisms to chemical toxicity (English)

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13 September 2017

D V Parke

1

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13 September 2017

publication date

1 January 1987

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13 September 2017

published in

Archives of Toxicology

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13 September 2017

volume

60

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13 September 2017

issue

1-3

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13 September 2017

page(s)

5-15

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https://scigraph.springernature.com/pub.10.1007/bf00296939

13 September 2017

exact match

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cites work

Ellipticines as potent inhibitors of microsomes- dependent chemical mutagenesis

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12 December 2020

Effects of phenobarbital and 3-methylcholanthrene on the in vivo distribution, metabolism and covalent binding of 4-ipomeanol in the rat; implications for target organ toxicity

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12 December 2020

The role of mitomycin antibiotics in the chemotherapy of solid tumors

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12 December 2020

Determination of cytochrome P-448 activity in biological tissues

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12 December 2020

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12 December 2020

Glucocorticoid and progesterone receptors bind to the same sites in two hormonally regulated promoters

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12 December 2020

Metabolism and activation of aflatoxin B1 by reconstituted cytochrome P-450 system of rat liver

1 reference

12 December 2020

The role of cytochrome P-450 forms in 2-aminoanthracene and benz[α]pyrene mutagenesis

1 reference

12 December 2020

Characteristics of a microsomal cytochrome P-448-mediated reaction. Ethoxyresorufin O-de-ethylation

1 reference

12 December 2020

Inactivation of a diol-epoxide and a K-region epoxide with high efficiency by glutathione transferase X

1 reference

12 December 2020

The role of highly purified cytochrome P-450 isozymes in the activation of 4-aminobiphenyl to mutagenic products in the Ames test.

1 reference

12 December 2020

Effects of the modulation of epoxide hydrolase activity on the binding of benzo[a]pyrene metabolites to DNA in the intact nuclei

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12 December 2020

NH2-terminal sequence analyses of four rat hepatic microsomal cytochromes P-450

1 reference

12 December 2020

Prostaglandin endoperoxide synthetase-mediated metabolism of carcinogenic aromatic amines and their binding to DNA and protein.

1 reference

12 December 2020

Metabolism of 2-acetylaminofluorene by eight different forms of cytochrome P-450 isolated from rat liver.

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12 December 2020

Suitability of animal models for predictive toxicology: theoretical and practical considerations

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12 December 2020

Glucuronidation of carcinogenic arylamine metabolites by rat liver microsomes.

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12 December 2020

Mechanisms of chemical toxicity--a unifying hypothesis

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12 December 2020

Aldrin epoxidation catalyzed by purified rat-liver cytochromes P-450 and P-448. High selectivity for cytochrome P-450.

1 reference

12 December 2020

Catalysis of divergent pathways of 2-acetylaminofluorene metabolism by multiple forms of cytochrome P-450

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12 December 2020

Reactive metabolites of phenacetin and acetaminophen: a review

1 reference

12 December 2020

Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions. The oxidative O-dealkylation of 7-ethoxycoumarin

1 reference

12 December 2020

Inhibition of cytochrome P-448 mixed function oxidase activity following administration of 9-hydroxyellipticine to rats

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12 December 2020

Metabolic activation of glutamic acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole, by purified cytochrome P-450.

1 reference

12 December 2020

Molecular dimensions of the substrate binding site of cytochrome P-448

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12 December 2020

Cytochrome P-448 and the activation of toxic chemicals and carcinogens.

1 reference

12 December 2020

The role of nutrition in toxicology

1 reference

12 December 2020

Metabolic activation of mutagenic tryptophan pyrolysis products (Trp-P-1 and Trp-P-2) by a purified cytochrome P-450-dependent monooxygenase system.

1 reference

12 December 2020

Use of monoclonal antibody probes against rat hepatic cytochromes P-450c and P-450d to detect immunochemically related isozymes in liver microsomes from different species

1 reference

12 December 2020

Effects of cytochrome P1-450 inducers on the cell-surface receptors for epidermal growth factor, phorbol 12,13-dibutyrate, or insulin of cultured mouse hepatoma cells

1 reference

12 December 2020

Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat

1 reference

12 December 2020

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1 reference

12 December 2020

Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations

1 reference

12 December 2020

Coumarin 7-hydroxylase activity in human liver microsomes. Properties of the enzyme and interspecies comparisons

1 reference

12 December 2020

Purification of characterization of a minor form of hepatic microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls

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12 December 2020

Metabolic activation of paracetamol by highly purified forms of cytochrome P-450

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12 December 2020

The mutagenicity of 9-hydroxyellipticine and its induction of cytochrome P-448 activity in rat liver microsomes.

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12 December 2020

Carcinogens, drugs, and cytochromes P-450

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12 December 2020

Purification and characterization of microsomal cytochrome P-450s

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12 December 2020

Immunochemical study on the contributions of two molecular species of microsomal cytochrome P-450 to the metabolism of 2-acetylaminofluorene by rat liver microsomes

1 reference

12 December 2020

The highly tumorigenic 3,4-dihydrodiol is a principal metabolite formed from dibenzo[a,h]anthracene by liver enzymes

1 reference

12 December 2020

Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat

1 reference

12 December 2020

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.

1 reference

12 December 2020

Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes

1 reference

12 December 2020

Biochemical pharmacology of antiestrogen action

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12 December 2020

Participation of the microsomal electron transport system in mutagenic activation of 4-dimethylaminoazobenzene, 4-methylaminoazobenzene and their 3'-methyl-derivatives.

1 reference

12 December 2020

Survey of drug-metabolizing enzymes

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12 December 2020

The carcinogen, 7-hydroxymethyl-12-methylbenz[a]anthracene, is activated and covalently binds to DNA via a sulphate ester

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00296939

1 reference

13 September 2017

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