(Q39672002)

English

Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors

scientific article published on 3 August 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

retracted paper

2 references

Dataset for "Continued use of retracted papers: Temporal trends in citations and (lack of) awareness of retractions shown in citation contexts in biomedicine"

Continued use of retracted papers: Temporal trends in citations and (lack of) awareness of retractions shown in citation contexts in biomedicine

Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

reactive oxygen species

1 reference

based on heuristic

inferred from title

author name string

Ramaswamy Kannappan

1

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Jayaraj Ravindran

2

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Sahdeo Prasad

3

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Bokyung Sung

4

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Vivek R Yadav

5

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Simone Reuter

6

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Madan M Chaturvedi

7

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Bharat B Aggarwal

8

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

publication date

3 August 2010

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Molecular Cancer Therapeutics

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

2196-2207

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Cardioprotection with palm tocotrienol: antioxidant activity of tocotrienol is linked with its ability to stabilize proteasomes

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Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors

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Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway

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Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.

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Dietary tocotrienol reduces UVB-induced skin damage and sesamin enhances tocotrienol effects in hairless mice.

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Suppression of NF-kappabeta signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits

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In vivo angiogenesis is suppressed by unsaturated vitamin E, tocotrienol

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Disruption of mitochondria during tocotrienol-induced apoptosis in MDA-MB-231 human breast cancer cells

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Inhibition of proliferation and induction of apoptosis by gamma-tocotrienol in human colon carcinoma HT-29 cells

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A novel mechanism of natural vitamin E tocotrienol activity: involvement of ERbeta signal transduction.

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Tumor suppressive effects of tocotrienol in vivo and in vitro

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A comparison of tocopherol and tocotrienol for the chemoprevention of chemically induced rat mammary tumors

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Lipoxygenase inhibitors induce death receptor 5/TRAIL-R2 expression and sensitize malignant tumor cells to TRAIL-induced apoptosis.

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Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of gamma-tocotrienol in neoplastic mammary epithelial cells

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Tocotrienols: constitutional effects in aging and disease

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gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells

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RRR-gamma-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling

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LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors

1 reference

30 December 2023

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Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo

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Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity

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Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis

1 reference

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Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways

1 reference

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A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma

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30 December 2023

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Tocotrienol: the natural vitamin E to defend the nervous system?

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Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells.

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gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells

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Effect of chlorophyllin against oxidative stress in splenic lymphocytes in vitro and in vivo

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Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1.

1 reference

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Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.

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Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL).

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α-Tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: Implication for sensitisation of resistant cancer cells to TRAIL apoptosis

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Tocotrienol-rich fraction of palm oil activates p53, modulates Bax/Bcl2 ratio and induces apoptosis independent of cell cycle association

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Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP.

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Dietary flavonoids sensitize HeLa cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

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Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells

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Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing, and chemotherapy drug-sensitizing agent in human melanoma cells

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Tocotrienol offers better protection than tocopherol from free radical-induced damage of rat bone

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Reduction of DNA damage in older healthy adults by Tri E Tocotrienol supplementation

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Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling

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Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells

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Signalling pathways of the TNF superfamily: a double-edged sword

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Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site.

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Dietary alpha-tocopherol attenuates the impact of gamma-tocotrienol on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in chickens

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Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: involvement of NF-kappa B and reactive oxygen species-mediated p53 activation

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Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis: up-regulation of DR5 and inhibition of Yin Yang 1.

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Identification and characterization of a new member of the TNF family that induces apoptosis

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Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee)

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30 December 2023

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Bone marrow stroma confers resistance to Apo2 ligand/TRAIL in multiple myeloma in part by regulating c-FLIP.

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30 December 2023

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Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5).

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30 December 2023

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Identifiers

10.1158/1535-7163.MCT-10-0277

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

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