(Q39675044)

English

Ranpirnase (Frog RNase) Targeted with a Humanized, Internalizing, Anti–Trop-2 Antibody Has Potent Cytotoxicity against Diverse Epithelial Cancer Cells

scientific article published on July 27, 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Ranpirnase (frog RNase) targeted with a humanized, internalizing, anti-Trop-2 antibody has potent cytotoxicity against diverse epithelial cancer cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Ranpirnase (Frog RNase) Targeted with a Humanized, Internalizing, Anti–Trop-2 Antibody Has Potent Cytotoxicity against Diverse Epithelial Cancer Cells (English)

1 reference

10.1158/1535-7163.MCT-10-0338

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0338

11 June 2024

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author name string

Chien-Hsing Chang

1

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Pankaj Gupta

2

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Rosana Michel

3

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Meiyu Loo

4

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Yang Wang

5

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Thomas M. Cardillo

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20663928

11 June 2024

David M. Goldenberg

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20663928

11 June 2024

language of work or name

1 reference

National Center for Biotechnology Information

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20663928

11 June 2024

publication date

27 July 2010

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

full work available at URL

https://figshare.com/articles/journal_contribution/Supplementary_Data_from_Ranpirnase_Frog_RNase_Targeted_with_a_Humanized_Internalizing_Anti_Trop-2_Antibody_Has_Potent_Cytotoxicity_against_Diverse_Epithelial_Cancer_Cells/22485960/1/files/39937527.pdf

Portable Document Format

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20663928

11 June 2024

http://intl-mct.aacrjournals.org/cgi/content/abstract/9/8/2276

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20663928

11 June 2024

https://aacrjournals.org/mct/article-pdf/9/8/2276/1887938/2276.pdf

Portable Document Format

1 reference

10.1158/1535-7163.MCT-10-0338

https://api.crossref.org/works/10.1158/1535-7163.MCT-10-0338

11 June 2024

Molecular Cancer Therapeutics

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

2276-2286

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

Ranpirnase (Onconase), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy

1

1 reference

10.1158/1535-7163.MCT-10-0338

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Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes

2

1 reference

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Ribonucleases as novel chemotherapeutics : the ranpirnase example

3

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Ribonucleases as a novel pro-apoptotic anticancer strategy: review of the preclinical and clinical data for ranpirnase

4

1 reference

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Phase II trial of a single weekly intravenous dose of ranpirnase in patients with unresectable malignant mesothelioma

6

1 reference

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Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: potential for the treatment of non-Hodgkin lymphoma

8

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Effective therapy of human lymphoma xenografts with a novel recombinant ribonuclease/anti-CD74 humanized IgG4 antibody immunotoxin

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Antiproliferative activity of a humanized anti-CD74 monoclonal antibody, hLL1, on B-cell malignancies

10

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IgG4 breaking the rules

11

1 reference

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The structural integrity exerted by N-terminal pyroglutamate is crucial for the cytotoxicity of frog ribonuclease from Rana pipiens

12

1 reference

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Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas

13

1 reference

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Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2

14

1 reference

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Human Trop-2 is a tumor-associated calcium signal transducer

15

1 reference

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Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers

16

1 reference

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Trop2: a possible therapeutic target for late stage epithelial carcinomas

17

1 reference

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Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors.

18

1 reference

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Clinical significance of TROP2 expression in colorectal cancer

19

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Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer

20

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TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity

21

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Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics

22

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Murine monoclonal antibodies raised against human non-small cell carcinoma of the lung: specificity and tumor targeting

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Specificity and properties of MAb RS7-3G11 and the antigen defined by this pancarcinoma monoclonal antibody

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Comparative biodistribution and radioimmunotherapy of monoclonal antibody RS7 and its F(ab')2 in nude mice bearing human tumor xenografts

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In vitro and in vivo reactivity of an internalizing antibody, RS7, with human breast cancer

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Development of humanized antibodies as cancer therapeutics

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Immunotoxins for targeted cancer therapy

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Immunotoxin therapy of cancer

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Immunotoxin treatment of cancer

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Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies

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A new RNase-based immunoconjugate selectively cytotoxic for ErbB2-overexpressing cells

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A fully human antitumor immunoRNase selective for ErbB-2-positive carcinomas.

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Targeted therapeutic RNases (ImmunoRNases)

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Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms

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Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia

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Reducing the immune response to immunotoxin

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Intracellular pathway of Onconase that enables its delivery to the cytosol

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Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway

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A Study of the Intracellular Routing of Cytotoxic Ribonucleases

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Endocytotic internalization as a crucial factor for the cytotoxicity of ribonucleases

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Intracellular route and mechanism of action of ERB-hRNase, a human anti-ErbB2 anticancer immunoagent

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Human antibody RNase fusion protein targeting CD30+ lymphomas.

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Identifiers

10.1158/1535-7163.MCT-10-0338

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 September 2017

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