(Q39697046)

14 September 2017

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title

Membrane transport and the antineoplastic action of nucleoside analogues (English)

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14 September 2017

F M Sirotnak

1

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14 September 2017

J R Barrueco

series ordinal

2

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14 September 2017

publication date

1 January 1987

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Cancer and Metastasis Reviews

14 September 2017

published in

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14 September 2017

volume

6

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14 September 2017

issue

4

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14 September 2017

page(s)

459-480

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https://scigraph.springernature.com/pub.10.1007/bf00047462

14 September 2017

exact match

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cites work

The kinetic dissection of transport from metabolic trapping during substrate uptake by intact cells. Uridine uptake by quiescent and serum-activated nil 8 hamster cells and their murine sarcoma virus-transformed counterparts

1 reference

https://api.crossref.org/works/10.1007%2FBF00047462

Trans-stimulation and trans-inhibition of uridine efflux from human erythrocytes by permeant nucleosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00047462

Nucleoside transport in Walker 256 rat carcinosarcoma and S49 mouse lymphoma cells. Differences in sensitivity to nitrobenzylthioinosine and thiol reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00047462

Kinetics of nitrobenzylthioinosine binding to the human erythrocyte nucleoside transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00047462

The kinetics of dissociation of the inhibitor of nucleoside transport, nitrobenzylthioinosine, from the high-affinity binding sites of cultured hamster cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00047462

Binding of nitrobenzylthioinosine to high-affinity sites on the nucleoside-transport mechanism of HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00047462

Proteolytic cleavage of [3H]nitrobenzylthioinosine-labelled nucleoside transporter in human erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00047462

Erythrocyte nucleoside and sugar transport. Endo-beta-galactosidase and endoglycosidase-F digestion of partially purified human and pig transporter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00047462

Identification of the nucleoside transporter in cultured mouse lymphoma cells. Photoaffinity labeling of plasma membrane-enriched fractions from nucleoside transport-competent (S49) and nucleoside transport-deficient (AE1) cells with [3H]nitrobenzyl

21 January 2018

1 reference

12 December 2020

Transport of nucleosides, nucleic acid bases, choline and glucose by animal cells in culture

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12 December 2020

Thymidine transport by cultured Novikoff hepatoma cells and uptake by simple diffusion and relationship to incorporation into deoxyribonucleic acid

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12 December 2020

Inhibition of nucleoside and nucleobase transport and nitrobenzylthioinosine binding by dilazep and hexobendine.

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12 December 2020

Thymidine accumulation by choroid plexus in vitro

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12 December 2020

Uridine uptake by isolated intestinal epithelial cells of guinea pig

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12 December 2020

Uptake of thymidine into isolated rat hepatocytes. Evidence for two transport systems

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12 December 2020

Binding of the Nucleoside Transport Inhibitor 4-Nitrobenzylthioinosine to Erythrocyte Membranes

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12 December 2020

Identification of the adenosine uptake sites in guinea pig brain

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12 December 2020

In vitro biological activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine and the biochemical actions of its triphosphate on DNA polymerases and ribonucleotide reductase from HeLa cells

1 reference

12 December 2020

Properties of the thymidine transport system of chinese hamster ovary cells as probed by nitrobenzylthioinosine

1 reference

12 December 2020

Treatment of mouse neoplasms with high doses of tubercidin

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12 December 2020

Effects of deoxyadenosine triphosphate and 9-beta-D-arabinofuranosyl-adenine 5'-triphosphate on human ribonucleotide reductase from Molt-4F cells and the concept of "self-potentiation"

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12 December 2020

Has the well gone dry? The First Cain Memorial Award Lecture

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12 December 2020

Photoaffinity labeling of the human erythrocyte nucleoside transporter by N6-(p-Azidobenzyl)adenosine and nitrobenzylthioinosine. Evidence that the transporter is a band 4.5 polypeptide.

1 reference

12 December 2020

Transport of uridine and 6-azauridine in human lymphoblastoid cells. Specificity for the uncharged 6-azauridine molecule

1 reference

12 December 2020

Species differences in nucleoside transport. A study of uridine transport and nitrobenzylthioinosine binding by mammalian erythrocytes

1 reference

12 December 2020

New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties

1 reference

12 December 2020

Nucleoside transport in cultured mammalian cells. Multiple forms with different sensitivity to inhibition by nitrobenzylthioinosine or hypoxanthine

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12 December 2020

Nitrobenzylthioinosine-sensitive and -resistant nucleoside transport in normal and transformed rat cells.

1 reference

12 December 2020

Modification by nitrobenzylthioinosine-5'-monophosphate of pseudoisocytidine pharmacokinetics in mice and rats through inhibition of membrane transport

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12 December 2020

Metabolism and therapeutic efficacy of 9-beta-D-arabinofuranosyl-2-fluoroadenine against murine leukemia P388

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12 December 2020

Absence of binding sites for the transport inhibitor nitrobenzylthioinosine on nucleoside transport-deficient mouse lymphoma cells

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12 December 2020

Hypoxanthine transport in mammalian cells: cell type-specific differences in sensitivity to inhibition by dipyridamole and uridine

1 reference

12 December 2020

Transport of deoxycoformycin in human erythrocytes. Measurement by adenosine deaminase titration and radioisotope assays

1 reference

12 December 2020

Inhibition of adenosine uptake in human erythrocytes by adenosine-5'-carboxamides, xylosyladenine, dipyridamole, hexobendine, and p-nitrobenzylthioguanosine

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12 December 2020

Metabolism and selective cytotoxicity of 9-beta-D-arabinofuranosylguanine in human lymphoblasts.

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12 December 2020

Comparison of the effects on cultured L1210 leukemia cells of the ribosyl, 2'-deoxyribosyl, and xylosyl homologs of tubercidin and adenosine alone or in combination with 2'-deoxycoformycin

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12 December 2020

Adenosine transport and metabolism in mouse leukemia cells and in canine thymocytes and peripheral blood leukocytes

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12 December 2020

Selection of 9-beta-D-arabinofuranosyladenine-resistant human T-lymphoblasts with altered ribonucleotide reductase activity

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12 December 2020

Metabolic stability of the nucleoside transport system of novikoff rat hepatoma cells

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12 December 2020

Use of 4-nitrobenzylthioinosine in the measurement of rates of nucleoside transport in human erythrocytes

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12 December 2020

Distinguishing between membrane transport and intracellular metabolism of fluorodeoxyuridine in Ehrlich ascites tumor cells by application of kinetic and high performance liquid chromatographic techniques

1 reference

12 December 2020

Specificity of systems mediating transport of adenosine, 9-beta-d-arabinofuranosyl-2-fluoroadenine, and other purine nucleoside analogues in L1210 cells

1 reference

12 December 2020

Comparison of the toxicity and metabolism of 9-beta-D-arabinofuranosyl-2-fluoroadenine and 9-beta-D-arabinofuranosyladenine in human lymphoblastoid cells

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12 December 2020

Initial rate kinetics of the transport of adenosine and 4-amino-7-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine (tubercidin) in cultured cells

1 reference

12 December 2020

Nucleoside transport in choroid plexus: mechanism and specificity.

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12 December 2020

Biologic activity of 9-β-d-arabinofuranosyl-2-fluoroadenine, a metabolically stable analog of 9-β-d-arabinofuranosyladenine

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12 December 2020

Specificity and sodium dependence of the active nucleoside transport system in choroid plexus.

1 reference

12 December 2020

Nucleoside transport in mammalian cell membranes. IV. Organomercurials and organomercurial-mercaptonucleoside complexes as probes for nucleoside transport systems in hamster cells

1 reference

12 December 2020

New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models

1 reference

12 December 2020

Proposed mechanism of therapeutic selectivity for 9-beta-D-arabinofuranosyl-2-fluoroadenine against murine leukemia based upon lower capacities for transport and phosphorylation in proliferative intestinal epithelium compared to tumor cells

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12 December 2020

Comparison of the actions of 9-beta-D-arabinofuranosyl-2-fluoroadenine and 9-beta-D-arabinofuranosyladenine on target enzymes from mouse tumor cells.

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12 December 2020

Adenosine kinase from L1210 cells. Purification and some properties of the enzyme

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12 December 2020

Altered nucleoside transporters in mammalian cells selected for resistance to the physiological effects of inhibitors of nucleoside transport.

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12 December 2020

Transport of uridine and 3-deazauridine in cultured human lymphoblastoid cells.

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12 December 2020

Cytosine arabinoside transport by human leukaemic cells

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12 December 2020

Origin of thymidine kinase deficient (TK?) haploid frog cells via an intermediate thymidine transport deficient (TT?) phenotype

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12 December 2020

A Comparative Study of the Anticancer Activity of Some S-Substituted Derivatives of 6-Mercaptopurine and their Ribonucleosides

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12 December 2020

Mediated transport of nucleosides by human erythrocytes. Specificity toward purine nucleosides as permeants.

1 reference

12 December 2020

Enhancement of methotrexate cytotoxicity towards the MDA.MB.436 human breast cancer cell line by dipyridamole. The role of methotrexate polyglutamates

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12 December 2020

Arabinosyl-5-azacytosine: mechanisms of native and acquired resistance.

1 reference

12 December 2020

Competitive inhibition of the transport of nucleosides, hypoxanthine, choline and deoxyglucose by theophylline, papaverine and prostaglandins

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12 December 2020

Transport and metabolism of deoxycytidine and 1-beta-D-arabinofuranosylcytosine into cultured Novikoff rat hepatoma cells, relationship to phosphorylation, and regulation of triphosphate synthesis

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12 December 2020

Transport of two non-metabolized nucleosides, deoxycytidine and cytosine arabinoside, in a sub-line of the L1210 murine leukemia

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12 December 2020

Nucleoside transport in mammalian cell membranes: a specific inhibitory mechanism of high affinity probes

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12 December 2020

Tight binding inhibitors--VIII. Studies of the interactions of 2'-deoxycoformycin and transport inhibitors with the erythrocytic nucleoside transport system

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12 December 2020

Tight binding inhibitors--VI. Interactions of deoxycoformycin and adenosine deaminase in intact human erythrocytes and sarcoma 180 cells

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12 December 2020

Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precursor salvage by dipyridamole

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12 December 2020

Reconstitution studies of the human erythrocyte nucleoside transporter

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12 December 2020

Manipulation of toxicity and tissue distribution of tubercidin in mice by nitrobenzylthioinosine 5'-monophosphate

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12 December 2020

Sodium-dependent, concentrative nucleoside transport in cultured intestinal epithelial cells

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12 December 2020

Dipyridamole-insensitive nucleoside transport in mutant murine T lymphoma cells

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12 December 2020

Metabolism and selective effects of 1-beta-D-arabinofuranosylcytosine in L1210 and Host tissues in vivo

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12 December 2020

Pyrazofurin enhancement of 5-azacytidine antitumor activity in L5178Y and human leukemia cells

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12 December 2020

The Roles of Transport and Phosphorylation in Nutrient Uptake in Cultured Animal Cells

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12 December 2020

Synergistic inhibition of leukemia L1210 cell growth in vitro by combinations of 2-fluoroadenine nucleosides and hydroxyurea or 2,3-dihydro-1H-pyrazole[2,3-a]imidazole

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12 December 2020

Uridine transport and phosphorylation in mouse cells in culture: effect of growth-promoting factors, cell cycle transit and oncogenic transformation

1 reference

12 December 2020

Mechanism of synergy between N-phosphonacetyl-L-aspartate and dipyridamole in a human ovarian carcinoma cell line

1 reference

12 December 2020

Metabolism and cytotoxicity of 5-azacytidine in cultured Novikoff rat hepatoma and P388 mouse leukemia cells and their enhancement by preincubation with pyrazofurin

1 reference

12 December 2020

Purification and some properties of a deoxyribonucleoside kinase from L1210 cells

1 reference

12 December 2020

A Kinetic Analysis of the Uptake of Cytosine-beta-d-Arabinoside by Rat-B77 Cells. Differentiation between Transport and Phosphorylation

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12 December 2020

Purine and pyrimidine transport and phosphoribosylation and their interaction in overall uptake by cultured mammalian cells. A re-evaluation

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12 December 2020

Penetration of mouse fibroblasts by 2?-deoxyadenosine 5?-phosphate and incorporation of the nucleotide into DNA

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12 December 2020

Inhibition of 1-beta-D-arabinofuranosylcytosine transport and net accumulation by teniposide and etoposide in Ehrlich ascites cells and human leukemic blasts

1 reference

12 December 2020

Effect of sulfhydryl reagents on nucleoside transport in cultured mammalian cells

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12 December 2020

Therapy of mouse leukemia L1210 with combinations of nebularine and nitrobenzylthioinosine 5'-monophosphate

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12 December 2020

Potentiation of methotrexate toxicity by dipyridamole.

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12 December 2020

Nucleoside Transport. II. Inhibition by p-Nitrobenzylthioguanosine and Related Compounds

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12 December 2020

Role of adenosine uptake and metabolism by blood cells in the antiplatelet actions of dipyridamole, dilazep and nitrobenzylthioinosine

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12 December 2020

Highly selective drug combinations for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine

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12 December 2020

The deoxyribonucleoside transport systems of cultured Novikoff rat hepatoma cells.

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12 December 2020

Protection of mice against lethal dosages of nebularine by nitrobenzylthioinosine, an inhibitor of nucleoside transport

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12 December 2020

Transport of a nonphosphorylated nucleoside, 5'-deoxyadenosine, by murine leukemia L1210 cells

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12 December 2020

Uridine transport in novikoff rat hepatoma cells and other cell lines and its relationship to uridine phosphorylation and phosphorolysis

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12 December 2020

Nucleosides of 2-Fluoroadenine

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12 December 2020

Mediated transport of nucleosides in human erythrocytes. Specific binding of the inhibitor nitrobenzylthioinosine to nucleoside transport sites in the erythrocyte membrane

1 reference

12 December 2020

Defective facilitated diffusion of nucleosides, a primary mechanism of resistance to 5-fluoro-2'-deoxyuridine in the HCT-8 human carcinoma line.

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12 December 2020

Genetic analysis of the 6-thiobenzylpurine binding site of the nucleoside transporter in mouse lymphoblasts

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12 December 2020

Inhibition of carrier-mediated and non-mediated permeation processes by cytochalasin B

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12 December 2020

Photoaffinity labeling of adenosine transporter in cardiac membranes with nitrobenzylthioinosine

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12 December 2020

Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation.

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12 December 2020

Nucleoside transport in mammalian cell membranes. III. Kinetic and chemical modification studies of cytosine-arabinoside and uridine transport in hamster cells in culture

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12 December 2020

Testing and characterizing the simple carrier

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12 December 2020

The application of rapid kinetic techniques to the transport of thymidine and 3-O-methylglucose into mammalian cells in suspension culture

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12 December 2020

Heterogeneity of nucleoside transport in mammalian cells. Two types of transport activity in L1210 and other cultured neoplastic cells

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12 December 2020

Sodium gradient-energized concentrative transport of adenosine in renal brush border vesicles

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12 December 2020

Analysis of the inhibitory effects of VP-16-213 (etoposide) and podophyllotoxin on thymidine transport and metabolism in Ehrlich ascites tumor cells in vitro

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12 December 2020

Thymidine transport in cultured mammalian cells. Kinetic analysis, temperature dependence and specificity of the transport system

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12 December 2020

Cytosine arabinoside influx and nucleoside transport sites in acute leukemia

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12 December 2020

Initial rate kinetics and evidence for duality of mediated transport of adenosine, related purine nucleosides, and nucleoside analogues in L1210 cells.

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12 December 2020

Resistance to 9-beta-D-arabinofuranosyladenine in cultured leukemia L 1210 cells.

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12 December 2020

Thymidine incorporation in nucleoside transport-deficient lymphoma cells.

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12 December 2020

Studies on the uptake of nucleic acid precursors into cells in tissue culture

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12 December 2020

Uptake of nucleosides in density-inhibited cultures of 3T3 cells

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12 December 2020

Characterization of mouse lymphoma cells with altered nucleoside transport

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12 December 2020

Inhibition of the transport of adenosine, other nucleosides and hypoxanthine in Novikoff rat hepatoma cells by methylxanthines, papaverine, N6-cyclohexyladenosine and N6-phenylisopropyladenosine

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12 December 2020

Studies on the biologic activity of purine and pyrimidine analogs

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12 December 2020

Augmentation of 5-fluorouracil cytotoxicity in human colon cancer cells by dipyridamole

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12 December 2020

Metabolism and chemotherapeutic activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine against murine leukemia L1210 and evidence for its phosphorylation by deoxycytidine kinase

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12 December 2020

Transport of nucleoside drugs in animal cells

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12 December 2020

A common basis for inhibition of nucleoside transport by dipyridamole and nitrobenzylthioinosine?

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12 December 2020

Resistance to multiple adenine nucleoside and methionine analogues in mutant murine lymphoma cells with enlarged S-adenosylmethionine pools.

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12 December 2020

Nucleoside transport by Novikoff rat hepatoma cells glowing in suspension culture. Specificity and mechanism of transport reactions and relationship to nucleoside incorporation into nucleic acids

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12 December 2020

Mediated transport of nucleosides in human erythrocytes. Accelerative exchange diffusion of uridine and thymidine and specificity toward pyrimidine nucleosides as permeants

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12 December 2020

Uphill transport of pyrimidine nucleosides in renal brush border vesicles.

1 reference

12 December 2020

New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.

1 reference

12 December 2020

Characterization of a mutant mouse lymphoma cell with deficient transport of purine and pyrimidine nucleosides

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12 December 2020

Isolation and characterization of thymidine transport mutants of Chinese hamster cells

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12 December 2020

Loss of a thermolabile thymidine kinase activity in bromodeoxyuridine resistant (transport deficient, kinase positive) haploid cultured frog cells

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12 December 2020

Nucleoside transport. Photoaffinity labelling of high-affinity nitrobenzylthioinosine binding sites in rat and guinea pig lung

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12 December 2020

Incorporation of 9-beta-D-arabinofuranosyl-2-fluoroadenine into HL-60 cellular RNA and DNA

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12 December 2020

Binding of the nucleoside transport inhibitor nitrobenzylthioinosine to HeLa cells

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12 December 2020

Modulation of cytarabine uptake and toxicity by dipyridamole

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12 December 2020

Low specificity of the nucleoside transport mechanism of RPMI 6410 cells

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12 December 2020

2-fluoro-ATP: a toxic metabolite of 9-beta-D-arabinosyl-2-fluoroadenine

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12 December 2020

Defective transport of thymidine by cultured cells resistant to 5-bromodeoxyuridine

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12 December 2020

Nitrobenzylthioinosine-insensitive uridine transport in human lymphoblastoid and murine leukemia cells

1 reference

12 December 2020

Dipyridamole inhibits reversion by thymidine of methotrexate effect and increases drug uptake in Sarcoma 180 cells

1 reference

12 December 2020

Effects of acivicin and dipyridamole on hepatoma 3924A cells

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00047462

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14 September 2017

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