(Q39704229)

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Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF-beta1-stimulated NRK-49F cells

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF-beta1-stimulated NRK-49F cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

extracellular matrix

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author name string

Bin Zhu

1

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Yong-jun Wang

2

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Cai-feng Zhu

3

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Yi Lin

4

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Xiao-ling Zhu

5

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Sheng Wei

6

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Ying Lu

7

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Xiao-xia Cheng

8

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

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publication date

25 April 2010

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Europe PubMed Central

PubMed publication ID

14 September 2017

Nephrology Dialysis Transplantation

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Europe PubMed Central

PubMed publication ID

14 September 2017

25

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

3180-3191

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro

1 reference

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21 January 2018

Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking

1 reference

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21 January 2018

The effect of triptolide on CD4+ and CD8+ cells in Peyer's patch of SD rats with collagen induced arthritis.

1 reference

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21 January 2018

Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Triptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritis

1 reference

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21 January 2018

Therapeutic effect of combined triptolide and glycyrrhizin treatment on rats with collagen induced arthritis

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Enhanced antitumor effect of combined triptolide and ionizing radiation

1 reference

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21 January 2018

Triptolide inhibits NF-kappaB activation and reduces injury of donor lung induced by ischemia/reperfusion

1 reference

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21 January 2018

Inhibitory effect of triptolide on lymph node metastasis in patients with non-Hodgkin lymphoma by regulating SDF-1/CXCR4 axis in vitro

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Inhibition of p38 mitogen-activated protein kinase and transforming growth factor-beta1/Smad signaling pathways modulates the development of fibrosis in adriamycin-induced nephropathy.

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

p38 MAPK mediates the expression of type I collagen induced by TGF-beta 2 in human retinal pigment epithelial cells ARPE-19.

1 reference

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21 January 2018

Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542

1 reference

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21 January 2018

Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells.

1 reference

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21 January 2018

Leptin augments myofibroblastic conversion and fibrogenic activity of human peritoneal mesothelial cells: a functional implication for peritoneal fibrosis.

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Protective effect of COMP-angiopoietin-1 on cyclosporine-induced renal injury in mice

1 reference

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21 January 2018

TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in rat renal fibroblasts

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Possible involvement of mitogen-activated protein kinase in the angiotensin II-induced fibronectin synthesis in renal interstitial fibroblasts

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Activation of Erk1/2 and Akt following unilateral ureteral obstruction.

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Long-term exposure of proximal tubular epithelial cells to glucose induces transforming growth factor-beta 1 synthesis via an autocrine PDGF loop

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Role of mitogen-activated protein kinase in the regulation of transforming growth factor-beta-induced fibronectin accumulation in cultured renal interstitial fibroblasts

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Triptolide is a potent suppressant of C3, CD40 and B7h expression in activated human proximal tubular epithelial cells.

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells.

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Triptolide affects the differentiation, maturation and function of human dendritic cells

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells.

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase-3beta with p53.

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Preservation and expansion of the primate keratocyte phenotype by downregulating TGF-beta signaling in a low-calcium, serum-free medium.

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

TGF-beta1 calcium signaling increases alpha5 integrin expression in osteoblasts

1 reference

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21 January 2018

Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction

1 reference

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21 January 2018

Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts.

1 reference

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21 January 2018

Emodin suppresses interleukin-1beta induced mesangial cells proliferation and extracellular matrix production via inhibiting P38 MAPK.

1 reference

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21 January 2018

Pressure loading and ethanol exposure differentially modulate rat hepatic stellate cell activation

1 reference

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21 January 2018

Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy

1 reference

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21 January 2018

The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells.

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ239

21 January 2018

Smad3 as a mediator of the fibrotic response

1 reference

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21 January 2018

AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan

1 reference

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21 January 2018

Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction.

1 reference

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21 January 2018

The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway

1 reference

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21 January 2018

TGF-beta 1/Smads signaling stimulates renal interstitial fibrosis in experimental AAN.

1 reference

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21 January 2018

Identifiers

10.1093/NDT/GFQ239

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

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