(Q39706036)

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p21 Downregulation is an important component of PAX3/FKHR oncogenicity and its reactivation by HDAC inhibitors enhances combination treatment.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20453878%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

p21 Downregulation is an important component of PAX3/FKHR oncogenicity and its reactivation by HDAC inhibitors enhances combination treatment (English)

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2 February 2020

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2 February 2020

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2 February 2020

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R M Hecker

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2 February 2020

R A Amstutz

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2 February 2020

M Wachtel

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2 February 2020

D Walter

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2 February 2020

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10 May 2010

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2 February 2020

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2 February 2020

29

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2 February 2020

27

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2 February 2020

3942-3952

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2 February 2020

https://scigraph.springernature.com/pub.10.1038/onc.2010.145

0 references

Phosphorylation regulates transcriptional activity of PAX3/FKHR and reveals novel therapeutic possibilities.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells

1 reference

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Superior activity of the combination of histone deacetylase inhibitor LAQ824 and the FLT-3 kinase inhibitor PKC412 against human acute myelogenous leukemia cells with mutant FLT-3.

1 reference

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Differentiation of rhabdomyosarcoma cell lines using retinoic acid

1 reference

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Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins.

1 reference

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21 January 2018

Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IV.

1 reference

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21 January 2018

Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody

1 reference

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21 January 2018

p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Lost in transcription: p21 repression, mechanisms, and consequences

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Strategies for silencing human disease using RNA interference

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Rhabdomyosarcoma--working out the pathways

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Soft tissue sarcomas of childhood

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Rhabdomyosarcoma and undifferentiated sarcoma in the first two decades of life: a selective review of intergroup rhabdomyosarcoma study group experience and rationale for Intergroup Rhabdomyosarcoma Study V.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Guilt by association: PAX3-FOXO1 regulates gene expression through selective destabilization of the EGR1 transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

21 January 2018

Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

31 March 2020

Isolation of genes differentially expressed in human primary myoblasts and embryonal rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

31 March 2020

Transcriptional activation of p21(WAF1/CIP1) by apicidin, a novel histone deacetylase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

31 March 2020

Survival after relapse in children and adolescents with rhabdomyosarcoma: A report from the Intergroup Rhabdomyosarcoma Study Group

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

31 March 2020

Which patients with microscopic disease and rhabdomyosarcoma experience relapse after therapy? A report from the soft tissue sarcoma committee of the children's oncology group

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.145

31 March 2020

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