(Q39710252)

English

A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

14 September 2017

A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models (English)

1 reference

Europe PubMed Central

14 September 2017

prostaglandin E2

1 reference

based on heuristic

inferred from title

author name string

Q Chen

1

1 reference

Europe PubMed Central

14 September 2017

K Muramoto

2

1 reference

Europe PubMed Central

14 September 2017

N Masaaki

3

1 reference

Europe PubMed Central

14 September 2017

Y Ding

4

1 reference

Europe PubMed Central

14 September 2017

H Yang

5

1 reference

Europe PubMed Central

14 September 2017

M Mackey

6

1 reference

Europe PubMed Central

14 September 2017

W Li

7

1 reference

Europe PubMed Central

14 September 2017

Y Inoue

8

1 reference

Europe PubMed Central

14 September 2017

K Ackermann

9

1 reference

Europe PubMed Central

14 September 2017

H Shirota

10

1 reference

Europe PubMed Central

14 September 2017

I Matsumoto

11

1 reference

Europe PubMed Central

14 September 2017

M Spyvee

12

1 reference

Europe PubMed Central

14 September 2017

S Schiller

13

1 reference

Europe PubMed Central

14 September 2017

T Sumida

14

1 reference

Europe PubMed Central

14 September 2017

F Gusovsky

15

1 reference

Europe PubMed Central

14 September 2017

M Lamphier

16

1 reference

Europe PubMed Central

14 September 2017

language of work or name

0 references

publication date

1 May 2010

1 reference

Europe PubMed Central

14 September 2017

British Journal of Pharmacology

1 reference

Europe PubMed Central

14 September 2017

160

1 reference

Europe PubMed Central

14 September 2017

2

1 reference

Europe PubMed Central

14 September 2017

292-310

1 reference

Europe PubMed Central

14 September 2017

Prostanoid receptor antagonists: development strategies and therapeutic applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Th17 cytokines and their emerging roles in inflammation and autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Effect of prostanoid EP4 receptor antagonist, CJ-042,794, in rat models of pain and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Effect of (S)-4-(1-(5-chloro-2-(4-fluorophenyoxy)benzamido)ethyl) benzoic acid (CJ-42794), a selective antagonist of prostaglandin E receptor subtype 4, on ulcerogenic and healing responses in rat gastrointestinal mucosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

CD97 neutralisation increases resistance to collagen-induced arthritis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Collagen-induced arthritis as a model for rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

EP2 and EP4 prostanoid receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Positive and negative regulation of T-cell activation through kinases and phosphatases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

The balance of Th1/Th2 cytokines in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Differential modulation of T helper type 1 (Th1) and T helper type 2 (Th2) cytokine secretion by prostaglandin E2 critically depends on interleukin-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

The promoter-regulatory region of the major immediate-early gene of human cytomegalovirus responds to T-lymphocyte stimulation and contains functional cyclic AMP-response elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

CJ-023,423, a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

14 September 2017

Therapeutic effects of antibodies to tumor necrosis factor-alpha, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

25 September 2017

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

25 September 2017

Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

15 June 2018

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

15 June 2018

Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-gamma production by memory CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

20 August 2018

Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

20 August 2018

E prostanoid 2 (EP2)/EP4-mediated suppression of antigen-specific human T-cell responses by prostaglandin E2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

20 August 2018

Prostaglandin E2 impairs CD4+ T cell activation by inhibition of lck: implications in Hodgkin's lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

20 August 2018

Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

20 August 2018

Role of cyclooxygenase-2, but not cyclooxygenase-1, on type II collagen-induced arthritis in DBA/1J mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

20 August 2018

Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

20 August 2018

Guide to Receptors and Channels (GRAC), 4th Edition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874852

1 October 2018

Two modes of analgesic action of aspirin, and the site of analgesic action of salicylic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/20423341

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20423341

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20423341

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid

1 reference

https://pubmed.ncbi.nlm.nih.gov/20423341

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra

1 reference

https://pubmed.ncbi.nlm.nih.gov/20423341

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 exacerbates collagen-induced arthritis in mice through the inflammatory interleukin-23/interleukin-17 axis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20423341

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of helper T cell function by prostaglandins

1 reference

https://pubmed.ncbi.nlm.nih.gov/20423341

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis and therapy of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20423341

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of interleukin-17 in cartilage and bone destruction in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20423341

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1476-5381.2010.00647.X

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q39710252&oldid=2089073129"