(Q39733748)

14 September 2017

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title

Guanfacine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension (English)

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14 September 2017

arterial hypertension

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E M Sorkin

1

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PubMed ID

3519177

14 September 2017

R C Heel

series ordinal

2

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14 September 2017

1 April 1986

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14 September 2017

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14 September 2017

31

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14 September 2017

301-336

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14 September 2017

4

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https://scigraph.springernature.com/pub.10.2165/00003495-198631040-00003

14 September 2017

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Characterisation of postjunctional ?-adrenoceptors in isolated human femoral veins and arteries

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Long-term antihypertensive therapy with guanfacine

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Improvement of glucose tolerance in hypertensive diabetic patients treated with guanfacine one year

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Effects of clonidine on biochemical indices of sympathetic function and plasma renin activity in normotensive man

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12 December 2020

Withdrawal of guanfacine after long-term treatment in essential hypertension. Observations on blood pressure and plasma and urinary noradrenaline

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12 December 2020

A multicenter, randomized, double-blind dose-response evaluation of step-2 guanfacine versus placebo in mild to moderate hypertension

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Guanfacine in essential hypertension: Effects during rest and isometric exercise

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Reduced Glucose Tolerance after Guanfacine in Normal and Obese Subjects

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Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors

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12 December 2020

Clinical pharmacology of the antihypertensive action of guanfacine

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12 December 2020

The over-shoot phenomenon on withdrawal of clonidine therapy

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12 December 2020

Effect of centrally acting alpha-adrenergic agonists on sympathetic nervous system function in humans

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Pharmacological evidence for stimulation of growth hormone secretion by a central noradrenergic system in dogs.

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Antihypertensive effect of N-amidino-2-(2,6-dichlorophenyl) acetamide hydrochloride. A double-blind cross-over trial versus clonidine

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Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents

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12 December 2020

Hemodynamic and endocrine responses to guanfacine in normotensive volunteers and hypertensive patients.

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12 December 2020

Effects of guanfacine on growth hormone, prolactin, renin, lipoproteins and glucose in essential hypertension

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12 December 2020

Precipitation by Yohimbine of the Withdrawal Syndromes of Clonidine, Guanfacine, and Methyldopa in the Spontaneously Hypertensive Rat

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12 December 2020

Comparative haemodynamic effects of clonidine and guanfacine

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12 December 2020

Effect of guanfacine on vigilance

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12 December 2020

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Systemic and cardiac haemodynamic interactions between guanfacine and hydrallazine in hypertensive patients.

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[3H]-guanfacine: a radioligand that selectively labels high affinity alpha2-adrenoceptor sites in homogenates of rat brain.

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alpha 1/alpha 2 Selectivity ratio in a series of agonists and their relation to pre/postsynaptic activity ratios

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Pharmacokinetics and metabolism of guanfacine in man: a review

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New evidence for growth hormone modulation by the α-adrenergic system in man

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12 December 2020

Comparison of Effects of Guanfacine and Clonidine on Blood Pressure, Heart Rate, Urinary Catecholamines, and Cyclic Nucleotides During and After Administration to Patients with Mild to Moderate Hypertension

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12 December 2020

Effect of guanfacine on blood pressure and renin activity in hypertensive patients

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Guanfacine: effects of long-term treatment and withdrawal

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Central effects of guanfacine and clonidine during wakefulness and sleep in healthy subjects

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Blood pressure and prolactin: effects of guanfacine. Three-year follow-up study

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A new centrally action antihypertensive agent guanfacine (BS 100-141)

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12 December 2020

Pharmacokinetics of guanfacine in patients undergoing haemodialysis

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12 December 2020

Induction of defective insulin secretion and impaired glucose tolerance by clonidine. Selective stimulation of metabolic alpha-adrenergic pathways

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12 December 2020

Hemodynamic effects of guanfacine in essential hypertension

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12 December 2020

Studies in the rat on the haemodynamic overshoot response to withdrawal of guanfacine or clonidine treatment

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12 December 2020

Evaluation of long-term treatment of essential hypertension with guanfacine

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12 December 2020

Long term comparative study of guanfacine and alpha-methyldopa in essential hypertension

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12 December 2020

Comparison of guanfacine versus clonidine for efficacy, safety and occurrence of withdrawal syndrome in step-2 treatment of mild to moderate essential hypertension

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12 December 2020

Peripheral alpha 2 adrenoceptor stimulation contributes to the sympatholytic effect of guanfacine in humans.

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12 December 2020

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12 December 2020

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12 December 2020

Effects of guanfacine on pre- and postsynaptic alpha-adrenoceptors studied in comparison with those of clonidine

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12 December 2020

Guanfacine in essential hypertension: effect on blood pressure, plasma noradrenaline concentration and plasma renin activity

1 reference

12 December 2020

Specific binding of 3H-guanfacine to alpha 2-adrenoceptors in rat brain. Comparison with 3H-clonidine

1 reference

12 December 2020

Comparative study of two antihypertensive agents: guanfacine and guanethidine

1 reference

12 December 2020

Comparison of the actions of centrally and peripherally administered clonidine and guanfacine in the rabbit: investigation of the differences

1 reference

12 December 2020

Determination of 3-hydroxy-guanfacine in biological fluids by electron-capture gas-liquid chromatography

1 reference

12 December 2020

Blood pressure and heart rate and withdrawal of antihypertensive drugs

1 reference

12 December 2020

Centrally acting drugs in antihypertensive therapy

1 reference

12 December 2020

Antihypertensive effect of BS 100-141, a new central acting antihypertensive agent

1 reference

12 December 2020

A comparative study of a new alpha-adrenoceptor agonist, guanfacine and alpha-methyldopa in the treatment of hypertension

1 reference

12 December 2020

[Pharmacokinetic study of guanfacine in patients with renal insufficiency and in patients under chronic dialysis (author's transl)]

1 reference

12 December 2020

Low-dose clonidine: a review of its therapeutic efficacy in migraine prophylaxis

1 reference

12 December 2020

The influence of renal function on plasma concentration, urinary excretion and antihypertensive effect of guanfacine

1 reference

12 December 2020

Clinical experience with guanfacine in long-term treatment of hypertension

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12 December 2020

Effect of guanfacine on pituitary hormones in man

1 reference

12 December 2020

Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure

1 reference

12 December 2020

Blood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute management

1 reference

12 December 2020

Relationships between blood pressure, heart rate and plasma epinephrine, norepinephrine, angiotensin II concentrations, plasma renin activity during chronic guanfacine therapy in patients with essential arterial hypertension

1 reference

12 December 2020

Comparison of clonidine and methyldopa on blood pressure and side effects in hypertensive patients

1 reference

12 December 2020

Long-term efficacy and tolerance of the antihypertensive agent guanfacine

1 reference

12 December 2020

Clinical experience with guanfacine in long-term treatment of hypertension. Part II: adverse reactions to guanfacine

1 reference

12 December 2020

Effects of single and multiple doses of guanfacine in essential hypertension

1 reference

12 December 2020

Pharmacological actions of the antihypertensive agent N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride (BS 100-141)

1 reference

12 December 2020

Studies on clonidine and guanfacine withdrawal after short term treatment in the rat

1 reference

12 December 2020

Hypotensive effect of guanfacine in essential hypertension: a comparison with clonidine

1 reference

12 December 2020

Effects of clonidine and guanfacine in essential hypertension.

1 reference

12 December 2020

Guanfacine in the treatment of hypertension due to pre-eclamptic toxaemia in thirty women

1 reference

12 December 2020

Effects of abrupt cessation of treatment with clonidine and guanfacine on blood pressure and heart rate in spontaneously hypertensive rats

1 reference

12 December 2020

Centrally mediated decrease in sympathetic tone induced by 2(2,6-dichlorophenylamino)-2 imidazoline (S.T. 155, Catapresan)

1 reference

12 December 2020

Clonidine and guanfacine in hypertension

1 reference

12 December 2020

[Antihypertensive therapy with guanfacine. A multicenter trial with Estulic Wander 1 mg]

1 reference

12 December 2020

Selectivity of a series of clonidine-like drugs for alpha 1 and alpha 2 adrenoceptors in rat brain

1 reference

12 December 2020

Clinical pharmacokinetics of methyldopa

1 reference

12 December 2020

Effects of clonidine and BS 100–141 on the EEG sleep pattern in rats

1 reference

12 December 2020

Inhibitory Effect of Guanfacine, a Central α-Adrenoceptor Agonist, on Prolactin Secretion Stimulated by Insulin-Induced Hypoglycemia

1 reference

12 December 2020

Determination of Guanfacine in Biological Fluids by Electron-Capture GLC

1 reference

12 December 2020

Pharmacology of centrally acting hypotensive drugs

1 reference

12 December 2020

Antihypertensive effect of guanfacine: a double-blind cross-over trial compared with clonidine

1 reference

12 December 2020

The central hyperglycaemic effect of clonidine

1 reference

12 December 2020

Guanfacine in the treatment of hypertension: two years' experience with low dose monotherapy

1 reference

12 December 2020

[125I]BE 2254, a new high affinity radioligand for α1-adrenoceptors

1 reference

12 December 2020

Double-blind trial comparing guanfacine and methyldopa in patients with essential hypertension

1 reference

12 December 2020

Blood pressure, heart rate, catecholamines and plasma renin activity following institution and withdrawal of guanfacine treatment in moderate hypertension

1 reference

12 December 2020

Evidence for a peripheral component in the sympatholytic actions of clonidine and guanfacine in man

1 reference

12 December 2020

Guanfacine and clonidine: antihypertensive and withdrawal characteristics after continuous infusion and its interruption in the spontaneously hypertensive and normotensive rat.

1 reference

12 December 2020

Guanfacine kinetics in patients with hypertension

1 reference

12 December 2020

Pharmacology of BS 100-141, a centrally acting antihypertensive drug

1 reference

12 December 2020

GTP regulates binding of agonists to alpha 2-adrenergic receptors in human platelets.

1 reference

12 December 2020

Haemodynamics in hypertensive patients before and during guanfacine treatment

1 reference

12 December 2020

[Haemodynamic investigations with the new antihypertensive drug guanfacine (author's transl)]

1 reference

12 December 2020

Binding characteristics of [3H]guanfacine to rat brain alpha-adrenoceptors. Comparison with [3H]clonidine.

1 reference

12 December 2020

Comparison of antihypertensive activity and tolerability of guanfacine and methyldopa

1 reference

12 December 2020

Haemodynamic effects of guanfacine

1 reference

12 December 2020

Duration of the hypotensive effect of guanfacine

1 reference

12 December 2020

10.2165/00003495-198631040-00003

Identifiers

DOI

1 reference

PubMed ID

3519177

Dimensions Publication ID

14 September 2017

0 references

1 reference

PubMed ID

3519177