(Q39775587)

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Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation (English)

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

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author name string

Ling Z

1

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Pipeleers DG

2

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

language of work or name

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publication date

1 December 1996

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Journal of Clinical Investigation

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Europe PubMed Central

PMC publication ID

14 September 2017

98

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

12

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

2805-2812

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

Differentiating glucose toxicity from glucose desensitization: a new message from the insulin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Physiologic relevance of heterogeneity in the pancreatic beta-cell population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Pancreatic B cells possess defense mechanisms against cell-specific toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Type II diabetes, glucose "non-sense," and islet desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Natural history of beta-cell dysfunction in NIDDM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Heterogeneity in Pancreatic β-cell Population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Glucose toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

22 September 2017

Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

25 September 2017

Concordant Glucose Induction of Glucokinase, Glucose Usage, and Glucose-Stimulated Insulin Release in Pancreatic Islets Maintained in Organ Culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

25 September 2017

Glucose induces oscillatory Ca2+ signalling and insulin release in human pancreatic beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

17 June 2018

Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

17 June 2018

Preservation of glucose-responsive islet beta-cells during serum-free culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

17 June 2018

Effects of glucose on the ultrastructure and insulin biosynthesis of isolated mouse pancreatic islets maintained in tissue culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

17 June 2018

Effects of high glucose on insulin secretion by isolated rat islets and purified beta-cells and possible role of glycosylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

17 June 2018

Viable purified islets of Langerhans from collagenase-perfused human pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

17 June 2018

In vitro exhaustion of pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

17 June 2018

Beta-cell hyperresponsiveness: earliest event in development of diabetes in monkeys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

17 June 2018

Pathogenesis of NIDDM. A balanced overview

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

17 June 2018

Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

20 August 2018

Characteristics of desensitization of insulin secretion in fully in vitro systems.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507747

20 August 2018

Glucose modulates glucose transporter affinity, glucokinase activity, and secretory response in rat pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8981928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal Glucose Regulation of Insulin Secretion in Models of Reduced B-Cell Mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/8981928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new in vitro model for the study of pancreatic A and B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8981928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human islets chronically exposed in vitro to different stimuli become unresponsive to the same stimuli given acutely: evidence supporting specific desensitization rather than beta-cell exhaustion

1 reference

https://pubmed.ncbi.nlm.nih.gov/8981928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic beta cell heterogeneity in glucose-induced insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/8981928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo and in vitro increased pancreatic beta-cell sensitivity to glucose in normal rats submitted to a 48-h hyperglycaemic period

1 reference

https://pubmed.ncbi.nlm.nih.gov/8981928

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI119108

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 September 2017

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