(Q39776310)

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SYUNZ-16, a newly synthesized alkannin derivative, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of AKT/FOXO signal pathway

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scholarly article

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Europe PubMed Central

14 September 2017

SYUNZ-16, a newly synthesized alkannin derivative, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of AKT/FOXO signal pathway (English)

1 reference

Europe PubMed Central

14 September 2017

apoptotic process

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author name string

Rong Deng

1

1 reference

Europe PubMed Central

14 September 2017

Jun Tang

2

1 reference

Europe PubMed Central

14 September 2017

Bing-Fen Xie

3

1 reference

Europe PubMed Central

14 September 2017

Gong-Kan Feng

4

1 reference

Europe PubMed Central

14 September 2017

Yu-Han Huang

5

1 reference

Europe PubMed Central

14 September 2017

Zong-Chao Liu

6

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Europe PubMed Central

14 September 2017

Xiao-Feng Zhu

7

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14 September 2017

language of work or name

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publication date

1 July 2010

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Europe PubMed Central

14 September 2017

International Journal of Cancer

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14 September 2017

127

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14 September 2017

1

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14 September 2017

220-229

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Europe PubMed Central

14 September 2017

Deregulation of the Akt pathway in human cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25032

21 January 2018

AKT/PKB signaling: navigating downstream

1 reference

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21 January 2018

Activation of AKT kinases in cancer: implications for therapeutic targeting

1 reference

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Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions

1 reference

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Mutant PIK3CA promotes cell growth and invasion of human cancer cells

1 reference

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Perturbations of the AKT signaling pathway in human cancer

1 reference

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Targeting the AKT protein kinase for cancer chemoprevention

1 reference

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Exploiting the PI3K/AKT pathway for cancer drug discovery

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SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor

1 reference

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Shikonin derivatives: synthesis and inhibition of human telomerase

1 reference

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21 January 2018

DMNQ S-64 induces apoptosis via caspase activation and cyclooxygenase-2 inhibition in human nonsmall lung cancer cells

1 reference

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21 January 2018

The molecular mechanisms involved in the cytotoxicity of alkannin derivatives

1 reference

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21 January 2018

Synthesis and cytotoxicity study of alkannin derivatives

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25032

21 January 2018

ApoG2, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces apoptosis and suppresses tumor growth in nasopharyngeal carcinoma xenografts

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Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis

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Blockade of vascular endothelial growth factor receptor signal pathway and antitumor activity of ON-III (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone), a component from Chinese herbal medicine.

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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21 January 2018

Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner.

1 reference

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21 January 2018

Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells

1 reference

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21 January 2018

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

1 reference

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Inhibition of akt/protein kinase B signaling by naltrindole in small cell lung cancer cells

1 reference

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The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells.

1 reference

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21 January 2018

Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis

1 reference

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21 January 2018

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25032

21 January 2018

FOXO transcription factors at the interface between longevity and tumor suppression

1 reference

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21 January 2018

AKT crystal structure and AKT-specific inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25032

21 January 2018

Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity

1 reference

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21 January 2018

The AKT inhibitor perifosine in biochemically recurrent prostate cancer: a phase II California/Pittsburgh cancer consortium trial

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21 January 2018

Identifiers

10.1002/IJC.25032

1 reference

Europe PubMed Central

14 September 2017

1 reference

Europe PubMed Central

14 September 2017

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