(Q39779287)

14 September 2017

Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles (English)

1 reference

14 September 2017

Yingcai Wang

1

1 reference

14 September 2017

Jiwen Jim Liu

2

1 reference

14 September 2017

Paul J Dransfield

3

1 reference

14 September 2017

Liusheng Zhu

4

1 reference

14 September 2017

Zhongyu Wang

5

1 reference

14 September 2017

Xiaohui Du

6

1 reference

14 September 2017

Xianyun Jiao

7

1 reference

14 September 2017

Yongli Su

8

1 reference

14 September 2017

An-Rong Li

9

1 reference

14 September 2017

Sean P Brown

10

1 reference

14 September 2017

Annie Kasparian

11

1 reference

14 September 2017

Marc Vimolratana

12

1 reference

14 September 2017

Ming Yu

13

1 reference

14 September 2017

Vatee Pattaropong

14

1 reference

14 September 2017

Jonathan B Houze

15

1 reference

14 September 2017

Gayathri Swaminath

16

1 reference

14 September 2017

Thanhvien Tran

17

1 reference

14 September 2017

Khanh Nguyen

18

1 reference

14 September 2017

Qi Guo

19

1 reference

14 September 2017

Jane Zhang

20

1 reference

14 September 2017

Run Zhuang

21

1 reference

14 September 2017

Frank Li

22

1 reference

14 September 2017

Lynn Miao

23

1 reference

14 September 2017

Michael D Bartberger

24

1 reference

14 September 2017

Tiffany L Correll

25

1 reference

14 September 2017

David Chow

26

1 reference

14 September 2017

Simon Wong

27

1 reference

14 September 2017

Jian Luo

28

1 reference

14 September 2017

Daniel C-H Lin

29

1 reference

14 September 2017

Julio C Medina

30

1 reference

14 September 2017

7 May 2013

1 reference

ACS Medicinal Chemistry Letters

14 September 2017

1 reference

14 September 2017

4

1 reference

14 September 2017

6

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14 September 2017

551-555

1 reference

Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Discovery of TAK-875: A Potent, Selective, and Orally Bioavailable GPR40 Agonist

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

International Union of Pharmacology. LXXI. Free fatty acid receptors FFA1, -2, and -3: pharmacology and pathophysiological functions

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

The determination of the absolute configurations of chiral molecules using vibrational circular dichroism (VCD) spectroscopy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Optimization of (2,3-dihydro-1-benzofuran-3-yl)acetic acids: discovery of a non-free fatty acid-like, highly bioavailable G protein-coupled receptor 40/free fatty acid receptor 1 agonist as a glucose-dependent insulinotropic agent.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Identification of fused-ring alkanoic acids with improved pharmacokinetic profiles that act as G protein-coupled receptor 40/free fatty acid receptor 1 agonists.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

AMG 837: a potent, orally bioavailable GPR40 agonist

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

Synthesis and activity of small molecule GPR40 agonists.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027505

3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900707

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Determination of absolute configuration using optical rotation calculated using density functional theory

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900707

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML300427U

1 reference

14 September 2017

1 reference

14 September 2017

PubMed publication ID

24900707

1 reference