(Q39782231)

English

Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O(6)-methylguanine-DNA methyltransferase(P140K).

scientific article published on 29 October 2009

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O(6)-methylguanine-DNA methyltransferase(P140K). (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

1 reference

based on heuristic

inferred from title

multiple drug resistance

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based on heuristic

inferred from title

author name string

P Maier

1

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Europe PubMed Central

PubMed publication ID

14 September 2017

I Spier

2

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

S Laufs

3

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

M R Veldwijk

4

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

S Fruehauf

5

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

F Wenz

6

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

W J Zeller

7

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

publication date

29 October 2009

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

17

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Europe PubMed Central

PubMed publication ID

14 September 2017

3

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Europe PubMed Central

PubMed publication ID

14 September 2017

389-399

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Europe PubMed Central

PubMed publication ID

14 September 2017

https://scigraph.springernature.com/pub.10.1038/gt.2009.133

0 references

Frequency analysis of multidrug resistance-1 gene transfer into human primitive hematopoietic progenitor cells using the cobblestone area-forming cell assay and detection of vector-mediated P-glycoprotein expression by rhodamine-123.

1 reference

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Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

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Multidrug resistance 1 gene transfer can confer chemoprotection to human peripheral blood progenitor cells engrafted in immunodeficient mice

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Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs

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Gene therapy for breast cancer. --Review of clinical gene therapy trials for breast cancer and MDR1 gene therapy trial in Cancer Institute Hospital

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DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

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Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea

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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

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Protection of hematopoietic cells from O(6)-alkylation damage by O(6)-methylguanine DNA methyltransferase gene transfer: studies with different O(6)-alkylating agents and retroviral backbones

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Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide

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Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro

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In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations

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Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy

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A novel dual function retrovirus expressing multidrug resistance 1 and O6-alkylguanine-DNA-alkyltransferase for engineering resistance of haemopoietic progenitor cells to multiple chemotherapeutic agents

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Improvement of combination chemotherapy tolerance by introduction of polycistronic retroviral vector drug resistance genes MGMT and MDR1 into human umbilical cord blood CD34+ cells

1 reference

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21 January 2018

Dual agent chemoprotection by retroviral co-expression of either MDR1 or MRP1 with the P140K mutant of O6-methylguanine-DNA-methyl transferase

1 reference

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Lentiviral gene transfer into peripheral blood-derived CD34+ NOD/SCID-repopulating cells

1 reference

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High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter

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IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector

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Improved co-expression of multiple genes in vectors containing internal ribosome entry sites (IRESes) from human genes.

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A new method to evaluate in vitro myelotoxicity of antitumour agents in the first steps of drug development.

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High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma

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Chemotherapy for non-small cell lung cancer: the experience of the Lung Cancer Cooperative Group of the European Organization for Research and Treatment of Cancer

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Phase I study of temozolomide plus paclitaxel in patients with advanced malignant melanoma and associated in vitro investigations.

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MGMT gene silencing and benefit from temozolomide in glioblastoma

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Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

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Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns

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Lentiviral vector integration sites in human NOD/SCID repopulating cells.

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Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

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The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

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Clinical application of lentiviral vectors - concepts and practice

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Gene therapy fulfilling its promise

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Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI

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Lentiviral vector gene transfer is limited by the proteasome at postentry steps in various types of stem cells

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LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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Improved post-transcriptional processing of an MDR1 retrovirus elevates expression of multidrug resistance in primary human hematopoietic cells

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Biochemistry of multidrug resistance mediated by the multidrug transporter

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Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation.

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O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings

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Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma

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A third-generation lentivirus vector with a conditional packaging system

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CD34 selection for purging in multiple myeloma and analysis of CD34+ B cell precursors

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Salvage chemotherapy with paclitaxel for recurrent primary brain tumors

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Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells

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No evidence of clonal dominance in primates up to 4 years following transplantation of multidrug resistance 1 retrovirally transduced long-term repopulating cells

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Identifiers

10.1038/GT.2009.133

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

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