(Q39819921)

14 September 2017

title

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism (English)

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14 September 2017

Ningning Ma

1

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14 September 2017

JoAnn Ellet

2

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14 September 2017

Centy Okediadi

3

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14 September 2017

Paul Hermes

4

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14 September 2017

Ellen McCormick

5

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14 September 2017

Susan Casnocha

6

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14 September 2017

publication date

1 September 2009

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14 September 2017

published in

Biotechnology Progress

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14 September 2017

volume

25

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14 September 2017

issue

5

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14 September 2017

page(s)

1353-1363

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Strategies for fed-batch cultivation of t-PA producing CHO cells: substitution of glucose and glutamine and rational design of culture medium

14 September 2017

cites work

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Deviant energetic metabolism of glycolytic cancer cells

21 January 2018

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Maximum activities of key enzymes of glycolysis, glutaminolysis, pentose phosphate pathway and tricarboxylic acid cycle in normal, neoplastic and suppressed cells

21 January 2018

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Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrations

21 January 2018

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Protein-free fed-batch culture of non-GS NS0 cell lines for production of recombinant antibodies

21 January 2018

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Fortification of a protein-free cell culture medium with plant peptones improves cultivation and productivity of an interferon-gamma-producing CHO cell line

21 January 2018

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Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production

21 January 2018

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Metabolic shifts by nutrient manipulation in continuous cultures of BHK cells

21 January 2018

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Oncogenic alterations of metabolism

21 January 2018

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Fed-batch culture optimization of a growth-associated hybridoma cell line in chemically defined protein-free media

21 January 2018

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Suppressed intrinsic catalytic activity of GLUT1 glucose transporters in insulin-sensitive 3T3-L1 adipocytes

21 January 2018

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Chemically defined medium for the production of biologically active substances of CHO cells

21 January 2018

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ATP citrate lyase inhibition can suppress tumor cell growth

21 January 2018

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The use of peptones as medium additives for the production of a recombinant therapeutic protein in high density perfusion cultures of mammalian cells

21 January 2018

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Expression of recombinant cytoplasmic yeast pyruvate carboxylase for the improvement of the production of human erythropoietin by recombinant BHK-21 cells

21 January 2018

1 reference

Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reaction

21 January 2018

1 reference

Blocking of acidosis-mediated apoptosis by a reduction of lactate dehydrogenase activity through antisense mRNA expression

21 January 2018

1 reference

Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin

21 January 2018

1 reference

Functional expression of human pyruvate carboxylase for reduced lactic acid formation of Chinese hamster ovary cells (DG44).

21 January 2018

1 reference

Analysis of the adult human plasma metabolome

21 January 2018

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Combined approach of NMR and chemometrics for screening peptones used in the cell culture medium for the production of a recombinant therapeutic protein.

21 January 2018

1 reference

Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer.

21 January 2018

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Transient responses of hybridoma cells to nutrient additions in continuous culture: I. Glucose pulse and step changes

21 January 2018

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Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production

21 January 2018

1 reference

Modification of glucose and glutamine metabolism in hybridoma cells through metabolic engineering.

21 January 2018

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Yeast hydrolysate as a low-cost additive to serum-free medium for the production of human thrombopoietin in suspension cultures of Chinese hamster ovary cells

21 January 2018

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Monitoring Chinese hamster ovary cell culture by the analysis of glucose and lactate metabolism

21 January 2018

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Gamma-interferon production and quality in stoichiometric fed-batch cultures of Chinese hamster ovary (CHO) cells under serum-free conditions

21 January 2018

1 reference

Stoichiometric analysis of animal cell growth and its application in medium design.

21 January 2018

1 reference

Toward consistent and productive complex media for industrial fermentations: studies on yeast extract for a recombinant yeast fermentation process

21 January 2018

1 reference

Development of Animal-free, Protein-Free and Chemically-Defined Media for NS0 Cell Culture

21 January 2018

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Fed-batch culture of recombinant NS0 myeloma cells with high monoclonal antibody production

21 January 2018

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High viable cell concentration fed-batch cultures of hybridoma cells through on-line nutrient feeding

21 January 2018

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Alteration of mammalian cell metabolism by dynamic nutrient feeding

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BTPR.238

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14 September 2017

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