(Q39824117)

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Blockade of IL-15 activity inhibits microglial activation through the NFkappaB, p38, and ERK1/2 pathways, reducing cytokine and chemokine release

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Blockade of IL-15 activity inhibits microglial activation through the NFkappaB, p38, and ERK1/2 pathways, reducing cytokine and chemokine release (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

microglial inhibitor

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author name string

Diego Gomez-Nicola

1

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Beatriz Valle-Argos

2

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Manuel Nieto-Sampedro

3

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

publication date

1 February 2010

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

58

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Europe PubMed Central

PubMed publication ID

14 September 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

264-276

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B

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Studies on the specificity and sensitivity of the influenza C virus binding assay for 9-O-acetylated sialic acids and its application to human melanomas

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Activation of interleukin-6 gene expression through the NF-kappa B transcription factor

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Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15.

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Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures

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Signalling events involved in interferon-gamma-inducible macrophage nitric oxide generation

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Reverse signaling through membrane-bound interleukin-15.

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IL-15/IL-15 receptor biology: a guided tour through an expanding universe

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Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor

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The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways

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Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression

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IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

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IL-2 and IL-15 manifest opposing effects on activation of nuclear factor of activated T cells

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Interleukin 15: biology and relevance to human disease

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Differential intracellular trafficking, secretion and endosomal localization of two IL-15 isoforms

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Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system

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Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor

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Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules

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Characterization of ameboid microglia isolated from developing mammalian brain.

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Regulation by GD3 of the proinflammatory response of microglia mediated by interleukin-15.

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Interleukin 15 expression in the CNS: blockade of its activity prevents glial activation after an inflammatory injury.

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Role of IL-15 in spinal cord and sciatic nerve after chronic constriction injury: regulation of macrophage and T-cell infiltration.

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Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

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p38 mitogen-activated protein kinase mediates lipopolysaccharide, not interferon-gamma, -induced inducible nitric oxide synthase expression in mouse BV2 microglial cells

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Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity.

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Gangliosides from human melanoma immunomodulate response of T cells to interleukin-2

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IL-15 and IL-15R alpha gene deletion: effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy

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Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

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p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

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1 reference

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1 reference

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Identifiers

10.1002/GLIA.20920

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 September 2017

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