(Q39833108)

15 September 2017

1 reference

title

In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis (English)

1 reference

15 September 2017

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

18 April 2023

1 reference

W. K. Lutz

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A390383

18 April 2023

language of work or name

English

0 references

publication date

1 December 1979

1 reference

full work available at URL

15 September 2017

https://api.elsevier.com/content/article/PII:016511107990006X?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

https://api.elsevier.com/content/article/PII:016511107990006X?httpAccept=text/plain

18 April 2023

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

18 April 2023

1 reference

15 September 2017

volume

65

1 reference

15 September 2017

issue

4

1 reference

15 September 2017

page(s)

289-356

1 reference

Molecular dosimetry of the mutagen ethyl methanesulfonate in Drosophila melanogaster spermatozoa: linear relation of DNA alkylation per sperm cell (dose) to sex-linked recessive lethals

15 September 2017

cites work

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Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test

18 April 2023

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Does carcinogenic potency correlate with mutagenic potency in the Ames assay?

18 April 2023

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Covalent binding of the carcinogen trichloroethylene to hepatic microsomal proteins and to exogenous DNA in vitro

18 April 2023

4

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Some aspects of metabolic activation of chemical carcinogens in relation to their organ specificity

18 April 2023

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Urethane interaction with nucleic acids and proteins from non-malignant fast growing tissues.

18 April 2023

7

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Disposition of (1,2-14C) vinyl chloride in the rat

18 April 2023

8

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Implication of Rifampicin-quinone in the Irreversible Binding of Rifampicin to Macromolecules

18 April 2023

9

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Inhibition of macromolecular binding of benzo(a)pyrene and inhibition of neoplasia by disulfiram in the mouse forestomach

18 April 2023

12

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The binding of 7,12-dimethylbenz(a)anthracene to replicating and non-replicating DNA in mouse skin

18 April 2023

13

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The replication of mouse skin epidermal DNA to which is bound 7,12-dimethylbenz(a)anthracene

18 April 2023

14

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Pulmonary bronchiolar alkylation and necrosis by 3-methylfuran, a naturally occurring potential atmospheric contaminant

18 April 2023

17

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Reaction of urethane with nucleic acids in vivo

18 April 2023

18

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Short term screening tests for carcinogens

18 April 2023

19

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The reaction of mustard gas with nucleic acids in vitro and in vivo

18 April 2023

20

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EVIDENCE FOR THE BINDING OF POLYNUCLEAR AROMATIC HYDROCARBONS TO THE NUCLEIC ACIDS OF MOUSE SKIN: RELATION BETWEEN CARCINOGENIC POWER OF HYDROCARBONS AND THEIR BINDING TO DEOXYRIBONUCLEIC ACID.

18 April 2023

21

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Excision of O6-methylguanine from DNA of various mouse tissues following a single injection of N-methyl-Nitrosourea

18 April 2023

26

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Mutation selection and the natural history of cancer

18 April 2023

27

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18 April 2023

The cancer problem

28

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On the binding of benz(a)pyrene to DNA "in vivo"

18 April 2023

29

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Binding of metabolites of dietary 4-dimethyl-aminoazobenzene and 2-methyl-4-dimethylamino-azobenzene to rat liver DNA and protein of subcellular fractions.

18 April 2023

31

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

METHYLATION OF LIVER DNA IN THE INTACT ANIMAL BY THE CARCINOGEN DIMETHYLNITROSAMINE DURING CARCINOGENESIS.

18 April 2023

42

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Analysis of bases of rat-liver nucleic acids after administration of the carcinogen dimethylnitrosamine

18 April 2023

43

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Effect of administration of the carcinogen dimethylnitrosamine on urinary 7-methylguanine

18 April 2023

44

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Stability of deoxyribonucleic acid methylated in the intact animal by administration of dimethylnitrosamine. Rate of breakdown in vivo and in vitro at different dosages

18 April 2023

45

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The reaction of N-methyl-N'-nitro-N-nitrosoguanidine with DNA in the intact animal

18 April 2023

46

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Analysis of DNA for the formation of 3-methylthymine after administration of dimethylnitrosamine

18 April 2023

47

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The pattern of methylated purines formed in DNA of intact and regenerating liver of rats treated with the carcinogen dimethylnitrosamine

18 April 2023

48

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Effect of a single treatment with the alkylating carcinogens dimethylnitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy

18 April 2023

49

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Effect of a single treatment with the alkylating carcinogens dimethylnitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy. II. Alkylation of DNA and inhibition of DNA replication

18 April 2023

50

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Comparative effect of phenobarbital and 3-methyl-cholanthrene on azodye metabolism in rat liver. I. In vitro studies on detoxication and activation processes

18 April 2023

52

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Comparative effect of phenobarbital and 3-methylcholanthrene on azo dye metabolism in rat liver. II. In vivo binding of metabolites to cellular macromolecules

18 April 2023

53

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Peroxidase-catalyzed irreversible binding of morphine to protein

18 April 2023

54

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The binding of metabolites of aminoazo dyes to rat liver DNA in vivo

18 April 2023

55

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Covalent binding of trans-stilbene to rat liver microsomes

18 April 2023

56

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Reaction of 7,12-dimethylbenz(a)anthracene with DNA of fetal and maternal rat tissuesin vivo

18 April 2023

57

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Metabolism and binding to cellular macromolecules of a series of hydrocarbons by mouse embryo cells in culture

18 April 2023

58

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Covalent Binding of 2,4-Diaminoanisole and 2,4-Diaminotoluene in vivo

18 April 2023

59

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

alpha-Naphthylisothiocyanate (ANIT) hepatotoxicity and irreversible binding to rat liver microsomes

18 April 2023

60

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Effects of feeding the carcinogen dimethylnitrosamine on its metabolism and methylation of DNA in the mouse

18 April 2023

62

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

In vivo repair of rat liver DNA damaged by dimethylnitrosamine or diethylnitrosamine

18 April 2023

63

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Possible mechanisms of combination effects in chemical carcinogenesis

18 April 2023

64

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Metabolic deactivation of mutagens in the Salmonella-microsome test

18 April 2023

66

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Tissue-dependent differences in dna methylation products of mice treated with methyl-labelled methylnitrosourea

18 April 2023

67

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Methylation of DNA in various organs of c57b1 mice by a carcinogenic dose of N-methyl-N-nitrosourea and stability of some methylation products up to 18 hours

18 April 2023

68

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Some mechanisms operative in carcinogenesis a review

18 April 2023

69

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Formation of a factor lethal for S. typhimurium TA1530 and TA1531 on incubation of aflatoxin B 1 with rat liver microsomes.

18 April 2023

70

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Binding of [14C]aflatoxin B1 to cellular macromolecules in the rat and hamster

18 April 2023

71

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Reduction III binding of [14C] aflatoxin B1 to rat liver macromolecules by phenobarbitone pretreatment

18 April 2023

72

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The properties of O 6 -methylguanine in templates for RNA polymerase

18 April 2023

73

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

A prospective on covalent binding and toxicity

18 April 2023

75

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Distribution and binding of radioactivity in the starling after intravenous administration of [14C]3-chloro-p-toluidine

18 April 2023

76

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Studies on the mechanism of inhibition of 2-acetylaminofluorene toxicity by butylated hydroxytoluene

18 April 2023

78

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Effect of pregnenolone-16alpha-caronitrile on the metabolism of dimethylnitrosamine and binding to rat liver macromolecules

18 April 2023

80

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The biological fate in rats of vinyl chloride in relation to its oncogenicity

18 April 2023

81

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Interactions of vinyl chloride with rat-liver DNA in vivo

18 April 2023

82

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Non-enzymatic and microsome-dependent binding of poly-cyclic hydrocarbons to DNA and polynucleotides

18 April 2023

83

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

In vivo reaction of dimethylnitrosamine with nucleic acids

18 April 2023

84

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Studies on the activation of a model furan compound--toxicity and covalent binding of 2-(N-ethylcarbamoylhydroxymethyl)furan

18 April 2023

85

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Investigation of alkylation in rat liver chromatin after application of 3H-cyclophosphamid--"fine-distribution" and kinetics

18 April 2023

86

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Probable methylation of nucleic acids of mouse colon by 1,2-dimethylhydrazine in vivo

18 April 2023

87

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

18 April 2023

Chemical carcinogenesis

91

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

In vivo and in vitro studies on irreversible binding of halothane metabolites to proteins

18 April 2023

93

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Macromolecular binding and metabolism of the carcinogen 1,2-dibromoethane

18 April 2023

95

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin

18 April 2023

96

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The in vivo binding of metabolites of 2-naphthylamine to mouse-liver DNA, RNA and protein

18 April 2023

97

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Binding of 14 C-labeled 4-nitroquinoline 1-oxide to DNA in vivo

18 April 2023

99

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Chloroform toxicity in mice: correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules

18 April 2023

100

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Persistent binding of 2-acetylaminofluorene to rat liver DNA in vivo and consideration of the mechanism of binding of N-hydroxy-2-acetylaminofluorene to rat liver nucleic acids

18 April 2023

101

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Influence of the aryl group on the reaction of glucuronides of N-arylacethydroxamic acids with polynucleotides

18 April 2023

104

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Comparative studies on the covalent binding of the carcinogen benzo(a)pyrene to DNA in various model systems

18 April 2023

106

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Covalent binding of ethinylestradiol and estrone to rat liver DNA in vivo.

18 April 2023

107

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Binding of36Cl-dieldrin to suspected target and non-target proteinsin vitro

18 April 2023

108

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

18 April 2023

111

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The in Vivo Toxicity of CS2 to Liver Microsomes: Binding of Labelled CS2 and Changes of the Microsomal Enzyme Activities

18 April 2023

112

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite

18 April 2023

114

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Irreversible protein binding of 14C-imipramine in rats in vivo

18 April 2023

118

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Reaction of methyl methanesulphonate with nucleic acids of fetal and newborn rats in vivo

18 April 2023

120

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Exhaustion and recovery of repair excision of O6-methylguanine from rat liver DNA

18 April 2023

122

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Covalent binding of 1-nitro-9-(3′-dimethyl-n-propylamino)acridine, a new antitumor drug, to DNA of ehrlich ascites tumor cells in vivo

18 April 2023

124

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Binding of Nenzo[ a ]pyrene 7,8-Diol-9,10-Epoxides to DNA, RNA, and Protein of Mouse Skin Occurs with High Stereoselectivity

18 April 2023

125

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

On the mechanism of action of carcinogenic aromatic amines. I. Binding of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene to rat-liver nucleic acids in vivo.

18 April 2023

126

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

On the mechanism of action of carcinogenic aromatic amines. II. Binding of N-hydroxy-N-acetyl-4-aminobiphenyl to rat-liver nucleic acids in vitro.

18 April 2023

127

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Persistent binding of a new reaction product of the carcinogen N-hydroxy-N-2-acetylaminofluorene with guanine in rat liver DNA in vivo

18 April 2023

128

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Reaction products of the carcinogen N-hydroxy-4-acetylamino-4'-fluorobiphenyl with DNA in liver and kidney of the rat

18 April 2023

129

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Covalent binding of drugs to tissue macromolecules as a biochemical mechanism of drug toxicities with special emphasis on chloramphenicol and thiamphenicol

18 April 2023

130

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Binding of aflatoxin to DNA as studied by optical detection of magnetic resonance

18 April 2023

131

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Paracetamol-induced hepatic necrosis in the mouse-relationship between covalent binding, hepatic glutathione depletion and the protective effect of alpha-mercaptopropionylglycine

18 April 2023

132

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Secondary structural modifications as a consequence of in vitro acetylation and phenanthrylation of DNA by the ultimate carcinogen N-acetoxy-N-2-acetylaminophenanthrene

18 April 2023

133

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

In vitro covalent binding to DNA of the ultimate carcinogen N-acetoxy-N-4-acetylaminobiphenyl

18 April 2023

134

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Methylated bases in liver nucleic acids from rats treated with dimethylnitrosamine

18 April 2023

136

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Methylation of nucleic acids by 2,2-dichlorovinyl dimethyl phosphate (dichlorvos, DDVP)

18 April 2023

137

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The effect of prolonged feeding of ortho-aminoazotoluene on binding to cellular constituents in mouse liver

18 April 2023

140

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The binding of ortho-aminoazotoluene in proliferating tissue

18 April 2023

141

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The interaction of [3H]ethyl carbamate with nucleic acids of regenerating mouse liver

18 April 2023

143

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The methylation of DNA in regenerating rat liver

18 April 2023

144

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Methylation of ribonucleic acid and deoxyribonucleic acid and tumour induction in livers of hypophysectomized rats treated with dimethylnitrosamine

18 April 2023

145

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Environmental Mutagenesis and Repair

18 April 2023

146

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Interaction of aflatoxins B1 and G1 with tissues of the rat

18 April 2023

148

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Alkylated purines in the DNA of various rat tissues after administration of 1,2-dimethylhydrazine

18 April 2023

150

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Structures of hepatic nucleic acid-bound dyes in rats given the carcinogen N-methyl-4-aminoazobenzene

18 April 2023

151

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Binding of Polycyclic Hydrocarbons to Rat Mammary Gland Cellular Macromolecules in Vivo

18 April 2023

153

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Warfarin binding to microsomes isolated from normal and warfarin-resistant rat liver

18 April 2023

154

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

18 April 2023

155

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Mechanism of the carcinogenic action of benzene: irreversible binding to rat liver DNA.

18 April 2023

157

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Saccharin does not bind to DNA of liver or bladder in the rat

18 April 2023

158

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Toxic liver injury and carcinogenesis. Methylation of rat-liver nucleic acids by dimethylnitrosamine in vivo

18 April 2023

160

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The effect of hormone induced stress upon the extent of alkylation of rat liver nucleic acids by N-methyl-N-nitrosourea

18 April 2023

162

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Distribution of (14C)MCA and its derivatives in mouse tissues (author's transl)

18 April 2023

163

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Chemical carcinogenesis in the nervous system. Preferential accumulation of O6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of N-methyl-N-nitrosourea

18 April 2023

165

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Hydroxyapatite column chromatography in procedures for isolation of purified DNA.

18 April 2023

166

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Binding of [G-3H]-7,12-dimethylbenz(α)anthracene to DNA of normal and of rapidly dividing hepatic cells of rats

18 April 2023

167

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Inhibitors of chemical carcinogens as probes for molecular targets: DNA as decisive receptor for metabolite from n-hydroxy-n-2-fluorenylacetamide

18 April 2023

169

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https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Phenobarbital-mediated increase in ring- and N-hydroxylation of the carcinogen N-2-fluorenylacetamide, and decrease in amounts bound to liver deoxyribonucleic acid

18 April 2023

170

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Tissue distribution of radioactivity in rats given tritiated analogues of hepatotoxic pyrrolizidine alkaloids

18 April 2023

171

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Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals

18 April 2023

172

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Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion

18 April 2023

173

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Effect of methylcholanthrene on 2-acetamidofluorene association with liver cell components.

18 April 2023

174

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Non-random binding of a chemical carcinogen to the DNA in chromatin

18 April 2023

176

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Cytochrome P-450-mediated covalent binding of hexachlorophene to rat tissue proteins

18 April 2023

179

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Binding of N-hydroxy acetylaminofluorene to eu- and heterochromatin fractions of rat liver in vivo

18 April 2023

181

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Generation of reactive metabolites of N-hydroxy-phenacetin by glucuronidation and sulfation

18 April 2023

182

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Distribution and cytogenetic test of 2,4-D and 2,4,5-T phenoxyacetic acids in mouse blood tissues

18 April 2023

186

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Isoniazid and Iproniazid: Activation of Metabolites to Toxic Intermediates in Man and Rat

18 April 2023

187

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2,3,7,8-tetrachlorodibenzo-p-dioxin: in vitro binding to rat liver microsomes

18 April 2023

188

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The metabolism and binding of ( 14 C)mycophenolic acid in the rat

18 April 2023

189

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Pharmacokinetic Parameters Influencing Tissue Specificity in Chemical Carcinogenesis

18 April 2023

190

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Cell-mediated mutagenesis in cultured Chinese hamster cells by carcinogenic polycyclic hydrocarbons: nature and extent of the associated hydrocarbon-DNA reaction

18 April 2023

191

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Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA

18 April 2023

192

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The accumulation of O6-methylguanine in the liver and kidney DNA of rats treated with dimethylinitrosamine for a short or a long period

18 April 2023

193

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Comparative Studies of the Hepatocarcinogen N,N-Dimethylnitrosamine in vivo: Reaction Sites in Rat Liver DNA and the Significance of their Relative Stabilities

18 April 2023

194

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Phosphotriesters in rat liver deoxyribonucleic acid after the administration of the carcinogen NN-dimethylnitrosamine in vivo

18 April 2023

195

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Retention of tritium during the binding of tritiated benzo(a)pyrene to DNA

18 April 2023

196

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Alkylation of RNA by vinyl bromide metabolites in vitro and in vivo

18 April 2023

198

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Alkylation of rat liver DNA by dimethylnitrosamine: effect of dosage on O6-methylguanine levels

18 April 2023

201

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Formation and Metabolism of Alkylated Nucleosides: Possible Role in Carcinogenesis by Nitroso Compounds and Alkylating Agents

18 April 2023

202

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Dimethylnitrosamine inhibits enzymatic removal of O6-methylguanine from DNA

18 April 2023

203

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Removal of methylated purines from rat liver DNA after administration of dimethylnitrosamine

18 April 2023

204

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Inhibition of the alkylation of nucleic acids and of the metabolism of 1,2-dimethylhydrazine by aminoacetonitrile

18 April 2023

205

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Enhancing effects of phenobarbitone and butylated hydroxytoluene on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat

18 April 2023

206

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The covalent binding of polycyclic hydrocarbons to DNA in the skin of mice of different strains

18 April 2023

207

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The binding of ethyl carbamate to DNA of mouse liver in vivo: the nature of the bound molecule and the site of binding

18 April 2023

208

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Studies on the mechanism of resistance to alkylating agents of three ascites tumours in the rat.

18 April 2023

209

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The mechanism of carcinogenic action of 1,2-dimethylhydrazine (sdmh) in rats

18 April 2023

210

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Evaluation of six short term tests for detecting organic chemical carcinogens and recommendations for their use.

18 April 2023

214

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A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat

18 April 2023

216

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Nitrosocarbaryl: its effect on human DNA.

18 April 2023

217

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The significance of covalent binding of catechols to proteins in vivo

18 April 2023

218

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In vivo and in vitro binding of carbon tetrachloride with nucleic acids and proteins in rat and mouse liver.

18 April 2023

221

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Metabolic activation of aromatic hydrocarbons in purified rat liver nuclei: induction of enzyme activities and binding to DNA with and without monooxygenase-catalyzed formation of active oxygen

18 April 2023

222

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Alkylation of nucleic acids of rat liver and lung by deuterated N-nitrosodiethylamine in vivo

18 April 2023

224

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Metabolism of N-nitrosohexamethyleneimine to give 1,6-hexanediol bound to rat liver nucleic acids

18 April 2023

225

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Oxygen-dependent reaction of 6-hydroxydopamine, 5,6-dihydroxytryptamine, and related compounds with proteins in vitro: a model for cytotoxicity

18 April 2023

226

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https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

14CEthylenethiourea: Distribution, excretion, and metabolism in pregnant rats

18 April 2023

227

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Organ distribution and nervous system binding of styrene and styrene oxide

18 April 2023

229

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Kinetics of formation of O6-ethylguanine in, and its removal from liver DNA of rats receiving diethylnitrosamine

18 April 2023

230

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Irreversible binding of dopa and dopamine metabolites to protein by rat liver microsomes

18 April 2023

231

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Combination effects in chemical carcinogenesis (experimental results)

18 April 2023

232

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Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in rats

18 April 2023

233

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Methylation of Nucleic Acids by N[14C]-Methyl-N-nitrosourethane in vitro and in vivo

18 April 2023

234

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Adducts between the carcinogen 2-acetamidophenanthrene and adenine and guanine of DNA

18 April 2023

235

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Dosimetry of the chemical mutagen ethyl methanesulfonate in spermatozoan DNA from Drosophila melanogaster

18 April 2023

236

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Dosimetry studies on the ethylation of mouse sperm DNA after in vivo exposure to (3H)ethyl metanesulfonate

18 April 2023

237

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Ethylation pf DNA and protamine by ethyl methanesulfonate in the germ cells of male mice and the relevancy of these molecular targets to the induction of dominant lethals

18 April 2023

238

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https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Repair deficient human disorders and cancer

18 April 2023

239

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https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

18 April 2023

240

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Covalent binding in vitro of polychlorinated biphenyls to microsomal macromolecules. Involvement of metabolic activation by a cytochrome P-450-linked mono-oxygenase system

18 April 2023

241

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The stability of methyl and ethyl phosphotriesters in DNA in vivo

18 April 2023

242

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The formation and stability of methyl phosphotriesters in the DNA of rat tissues after treatment with the carcinogen N,N-dimethylnitrosamine

18 April 2023

243

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The chemical effects of nucleic acid alkylation and their relation to mutagenesis and carcinogenesis

18 April 2023

244

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All oxygens in nucleic acids react with carcinogenic ethylating agents

18 April 2023

245

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Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: Role of cytochrome P-450

18 April 2023

246

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Methylation of nucleic acids and urinary excretion of 14 C-labeled 7-methylguanine by rats and man after administration of 4(5)-(3,3-dimethyl-1-triazeno)-imidazole5(4)-carboxomide.

18 April 2023

247

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Interaction of p-Dimethylaminoazobenzene with rat liver-chromatin and non-histones (author's transl)

18 April 2023

251

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Protection by dimethylsulfoxide of strand breaks in hepatic DNA induced by dimethylnitrosamine

18 April 2023

252

1 reference

https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Alterations in microsomal metabolism of benzo[a]pyrene in mice fed butylated hydroxyanisole

18 April 2023

253

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https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Effects of Administration to Mice of Butylated Hydroxyanisole by Oral Intubation on Benzo[ a ]pyrene-Induced Pulmonary Adenoma Formation and Metabolism of Benzo[ a ]pyrene 2

18 April 2023

254

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https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

2-Acetamidofluorene and 3-Methylcholanthrene: Differences in Binding to Rat Liver Deoxyribonucleic Acid in vivo

18 April 2023

255

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Cellular injury and carcinogenesis. Evidence for the alkylation of rat liver nucleic acids in vivo by N-nitrosomorpholine.

18 April 2023

257

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Evaluation of short-term tests for carcinogenicity

18 April 2023

258

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Immunodepression and malignancy

18 April 2023

259

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Reduced binding of carcinogenic hydrocarbons to DNA of mouse skin during inhibition of DNA synthesis.

18 April 2023

260

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Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate

18 April 2023

261

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Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucleic acids of the rat by diethylnitrosamine, N-ethyl-N-nitrosourea and ethyl methanesulphonate

18 April 2023

262

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Evidence for ethylation of rat liver deoxyribonucleic acid after administration of ethionine

18 April 2023

263

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1,2-Dimethylhydrazine-induced methylation of DNA bases in various rat organs and the effect of pretreatment with disulfiram

18 April 2023

264

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Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo

18 April 2023

265

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Stability of binding of label from N-hydroxy-N-2-fluorenylacetamide to intracellular targets, particularly deoxyribonucleic acid in rat liver

18 April 2023

266

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Irreversible binding of 3-14C-antipyrine to hepatic protein in vivo and in metabolizing liver microsomes

18 April 2023

268

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Interaction of a carcinogen, 4-hydroxyaminoquinoline-1-oxide with nucleic acids

18 April 2023

269

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Studies with cyclophosphamide labeled with phosphorus-32: nucleic acid alkylation and its effect on DNA synthesis in rat tumor and normal tissues

18 April 2023

270

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Covalent binding of foreign chemicals to tissue macromolecules

18 April 2023

271

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The mode of interaction of mitomycin C with deoxyribonucleic acid and other polynucleotides in vitro

18 April 2023

272

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Metabolic Activation of Haloalkanes and Testsin vitrofor Mutagenicity

18 April 2023

275

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Irreversible binding of 14C-labelled trichloroethylene to mice liver constituents in vivo and in vitro

18 April 2023

276

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Persistent Binding of Butter Yellow Metabolites to Rat Liver DNA

18 April 2023

278

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The covalent binding of metabolites of tritiated 2-methyl-4-dimethylamino-azobenzene to rat liver nucleic acids and proteins, and the carcinogenicity of the unlabelled compound in partially hepatectomised rats.

18 April 2023

279

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Hepatic macromolecular binding following exposure to vinyl chloride

18 April 2023

280

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Inhibitors of Chemical Carcinogenesis

18 April 2023

281

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Identification of the persistently bound form of the carcinogen N-acetyl-2-aminofluorene to rat liver DNA in vivo

18 April 2023

283

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Studies with mustards. III. In vivo fixation of C14 from nitrogen mustard-C14H3 in nucleic acid fractions of animal tissues

18 April 2023

284

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Studies with mustards. Iv. Effects of nitrogen mustard treatment of deoxyribonuclease and deoxyribonucleic acid upon the enzymic degradation of deoxyribonucleic acid

18 April 2023

285

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Tissue and subcellular distribution of 3H-dioxane in the rat and apparent lack of microsome-catalyzed covalent binding in the target tissue

18 April 2023

288

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In vivo alkylation studies with dichlorvos at practical use concentrations

18 April 2023

289

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Preferential alkylation of mitochondrial deoxyribonucleic acid by N-methyl-N-nitrosourea

18 April 2023

290

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https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Studies on nitrosodimethylamine: preferential methylation of mitochondrial DNA in rats and hamsters

18 April 2023

291

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https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

The ability of enteric bacteria to catalyze the covalent binding of bile acids and cholesterol to DNA and their inability to metabolize benzo(a)pyrene to a binding product and to known metabolites

18 April 2023

293

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https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

Methylation of intestinal and hepatic DNA in rats treated with methylazoxymethanol acetate

18 April 2023

294

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https://api.crossref.org/works/10.1016/0165-1110(79)90006-X

18 April 2023

Identifiers

1 reference

15 September 2017

1 reference