(Q39839020)

English

Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism

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scholarly article

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Europe PubMed Central

15 September 2017

Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism (English)

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Europe PubMed Central

15 September 2017

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1 reference

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7

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15 September 2017

author name string

P de Medina

1

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Europe PubMed Central

15 September 2017

B Payré

2

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Europe PubMed Central

15 September 2017

N Boubekeur

3

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Europe PubMed Central

15 September 2017

J Bertrand-Michel

4

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Europe PubMed Central

15 September 2017

F Tercé

5

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Europe PubMed Central

15 September 2017

S Silvente-Poirot

6

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Europe PubMed Central

15 September 2017

publication date

12 June 2009

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Europe PubMed Central

15 September 2017

Cell Death & Differentiation

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Europe PubMed Central

15 September 2017

16

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15 September 2017

10

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Europe PubMed Central

15 September 2017

1372-1384

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Europe PubMed Central

15 September 2017

https://scigraph.springernature.com/pub.10.1038/cdd.2009.62

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Molecular characterization of the microsomal tamoxifen binding site

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.62

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Multiple targeting by the antitumor drug tamoxifen: a structure-activity study.

1 reference

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Phase III study of N,N-diethyl-2-[4-(phenylmethyl) phenoxy]ethanamine (BMS-217380-01) combined with doxorubicin versus doxorubicin alone in metastatic/recurrent breast cancer: National Cancer Institute of Canada Clinical Trials Group Study MA.19.

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Phase II trial of tesmilifene plus mitoxantrone and prednisone for hormone refractory prostate cancer: high subjective and objective response in patients with symptomatic metastases

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Quality of life analyses in a clinical trial of DPPE (tesmilifene) plus doxorubicin versus doxorubicin in patients with advanced or metastatic breast cancer: NCIC CTG Trial MA.19.

1 reference

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Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.62

21 January 2018

Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor

1 reference

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21 January 2018

Autophagy delays apoptotic death in breast cancer cells following DNA damage

1 reference

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Quantitation of mitochondrial alterations associated with apoptosis

1 reference

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Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy.

1 reference

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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

1 reference

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Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

1 reference

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Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells

1 reference

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

1 reference

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21 January 2018

Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects

1 reference

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21 January 2018

Cholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npc1 -/- mouse brain

1 reference

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21 January 2018

Ordering effects of cholesterol and its analogues

1 reference

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Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.

1 reference

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Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line

1 reference

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A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance

1 reference

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21 January 2018

Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures

1 reference

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21 January 2018

Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress

1 reference

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21 January 2018

Regulation of cellular response to oncogenic and oxidative stress by Seladin-1

1 reference

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Phosphatidylserine recognition by phagocytes: a view to a kill

1 reference

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Roles of the innate immune system in mammary gland remodeling during involution

1 reference

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21 January 2018

Tamoxifen metabolism: pharmacokinetic and in vitro study

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.62

21 January 2018

The prototypical inhibitor of cholesterol esterification, Sah 58-035 [3-[decyldimethylsilyl]-n-[2-(4-methylphenyl)-1-phenylethyl]propanamide], is an agonist of estrogen receptors.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.62

21 January 2018

Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation

1 reference

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Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

1 reference

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21 January 2018

High-affinity anti-oestrogen binding site distinct from the oestrogen receptor

1 reference

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21 January 2018

A diphenylmethane derivative selective for the anti-estrogen binding site may help define its biological role

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis, binding and structure-affinity studies of new ligands for the microsomal anti-estrogen binding site (AEBS)

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.62

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of autophagy in bovine mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.62

7 January 2021

based on heuristic

inferred from DOI database lookup

Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease

1 reference

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Interconnections between E2-dependent regulation of cell cycle progression and apoptosis in MCF-7 tumors growing on nude mice

1 reference

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7 January 2021

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Identifiers

10.1038/CDD.2009.62

1 reference

Europe PubMed Central

15 September 2017

1 reference

Europe PubMed Central

15 September 2017

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