(Q39857371)

15 September 2017

1 reference

title

Lipophilicity and drug activity (English)

1 reference

structure-activity relationship

15 September 2017

main subject

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A397526

20 April 2023

author name string

H. Kubinyi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A397526

20 April 2023

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=397526

20 April 2023

publication date

1 January 1979

1 reference

full work available at URL

15 September 2017

http://link.springer.com/content/pdf/10.1007/978-3-0348-7105-1_5.pdf

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1007/978-3-0348-7105-1_5

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques

20 April 2023

published in

1 reference

15 September 2017

volume

23

1 reference

15 September 2017

page(s)

97-198

1 reference

Linear Relationships between Lipophilic Character and Biological Activity of Drugs

15 September 2017

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Quantitative structure-activity relationships. 3.1 A comparison of different Free-Wilson models

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Selection of a Reference Partitioning System for Drug Design Work

20 April 2023

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The Partition of Organic Compounds Between Higher Alcohols and Water

20 April 2023

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Oil‐Water Distribution of p‐Alkylpyridines

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Use of substituent constants in structure-activity relations and the importance of the choice of standard state

20 April 2023

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Calculation of hydrophobic constant (log P) from .pi. and f constants

20 April 2023

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Use of distribution coefficients in quantitative structure-activity relations

20 April 2023

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Physicochemical properties of beta-lactam antibiotics: oil-water distribution

20 April 2023

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Microelectrometric titration measurement of the pKa's and partition and drug distribution coefficients of narcotics and narcotic antagonists and their pH and temperature dependence

20 April 2023

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Oil-water partitioning of chlorpromazine and other phenothiazine derivatives using dodecane and n-octanol

20 April 2023

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Functional group contribution of bile salt molecules to partitioning of a quaternary ammonium N,N-dimethyl derivative of propranolol

20 April 2023

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DRUG PARTITIONING. II. IN VITRO MODEL FOR DRUG ABSORPTION

20 April 2023

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An in vitro model for soluble drug absorption

20 April 2023

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Drug transport through model membranes and its correlation with solubility parameters

20 April 2023

82

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Effect of Lipid Polarity and Cell Design on the In Vitro Transport of Salicylic Acid

20 April 2023

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Correlations between In Vitro Transport in a Three-Phase Model Cell and In Vivo Absorption of a Series of Sulfanilamides

20 April 2023

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Determination of Rate Constants for In Vitro Three-Compartment Transfer Using a Two-Phase System

20 April 2023

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ABSORPTION AND EXCRETION OF DRUGS. XIX. SOME PHARMACOKINETIC ASPECTS OF ABSORPTION AND EXCRETION OF SULFONAMIDES. (1). ABSORPTION FROM RAT STOMACH

20 April 2023

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Diffusional model for transport rate studies across membranes

20 April 2023

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Theoretical Model Studies of Drug Absorption and Transport in the Gastrointestinal Tract II

20 April 2023

88

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In vitro model for transport of solutes in three-phase system. II. Experimental considerations

20 April 2023

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Correlation and Prediction of Mass Transport across Membranes I: Influence of Alkyl Chain Length on Flux-Determining Properties of Barrier and Diffusant

20 April 2023

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Transport of alkyl Homologs Across Synthetic and Biological Membranes: A new Model for Chain Length-Activity Relationships

20 April 2023

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Drug Partitioning: Relationships between Forward and Reverse Rate Constants and Partition Coefficient

20 April 2023

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Physicochemical properties of medicinal agents. IV. Permeability of barbituric acid derivatives in absorption simulator (author's transl)

20 April 2023

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Improved transport apparatus for examining diffusion of drugs across isolated tissues and synthetic membranes

20 April 2023

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The use of polyamide membranes as an in vitro model for drug absorption [proceedings]

20 April 2023

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20 April 2023

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A Simple Assessment of Partition Data for Correlating Structure and Biological Activity Using Thin-Layer Chromatography

20 April 2023

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Chromatographic hydrophobic parameters in correlation analysis of structure-activity relationships

20 April 2023

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Proceedings: Hydrophobic substituent constants from thin-layer chromatography on polyamide plates.

20 April 2023

110

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Partition data of penicillins determined by means of reversed-phase thin-layer chromatography

20 April 2023

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Relationship between lipophilic character and hemolytic activity of testosterone and testosterone esters

20 April 2023

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Rm values of phenols. Their relation with log P values and activity

20 April 2023

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Rm values of steroids as an expression of their lipophilic character in structure-activity studies

20 April 2023

115

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Relationship between pi and Rm values of sulfonamides

20 April 2023

117

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Liquid-liquid partition coefficients by high-pressure liquid chromatography

20 April 2023

119

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High-pressure liquid chromatography of drugs. An evaluation of an octadecylsilane stationary phase

20 April 2023

121

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Direct measurement of octanol-water partition coefficients by high-pressure liquid chromatography

20 April 2023

122

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Use of high-pressure liquid chromatography for quantitative structure-activity relationship studies of sulfonamides and barbiturates

20 April 2023

123

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A comparison of the determination of partition coeficients of 1,4-benzodiazephines by high-performance liquid chromatography and thin-layer chromatography

20 April 2023

125

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Quantitative correlations between albumin binding constants and chromatographic RM values of phenothiazine derivatives

20 April 2023

126

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20 April 2023

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20 April 2023

128

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Molecular Connectivity I: Relationship to Nonspecific Local Anesthesia

20 April 2023

130

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Molecular Connectivity II: Relationship to Water Solubility and Boiling Point

20 April 2023

132

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Molecular Connectivity III: Relationship to Partition Coefficients

20 April 2023

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Molecular connectivity V: connectivity series concept applied to density

20 April 2023

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Molecular Connectivity VII: Specific Treatment of Heteroatoms

20 April 2023

135

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Molecular connectivity analyses of structure influencing chromatographic retention indexes

20 April 2023

136

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Molecular connectivity and steric parameters

20 April 2023

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Minimal statistical data for structure-function correlations

20 April 2023

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Chance correlations in structure-activity studies using multiple regression analysis

20 April 2023

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Molecular connectivity study of muscarinic receptor affinity of acetylcholine antagonists

20 April 2023

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Molecular connectivity. 4. Relations to biological activities

20 April 2023

141

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Molecular connectivity. 6. Examination of the parabolic relationship between molecular connectivity and biological activity

20 April 2023

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Structure-activity studies using valence molecular connectivity

20 April 2023

143

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Molecular Connectivity in Quantitative Structure-Activity Relationship Study of Anesthetic and Toxic Activity of Aliphatic Hydrocarbons, Ethers, and Ketones

20 April 2023

144

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Structure-activity studies on odor molecules using molecular connectivity

20 April 2023

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Structure-activity studies on hallucinogenic amphetamines using molecular connectivity

20 April 2023

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Molecular connectivity and substructure analysis

20 April 2023

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Partition coefficients and surface areas of some alkylbenzenes

20 April 2023

159

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Dependence of hydrophobicity of apolar molecules on their molecular volume

20 April 2023

160

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Interdependence between physical parameters and selection of substituent groups for correlation studies

20 April 2023

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Strategy in drug design. Cluster anlysis as an aid in the selection of substituents

20 April 2023

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Structure of medicinal chemistry

20 April 2023

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Physicochemical-activity relations in practice. 2. Rational selection of benzenoid substituents

20 April 2023

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Chemicobiological interactions and the use of partition coefficients in their correlation.

20 April 2023

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Structure-activity correlations for antibacterial agents on gram-positive and gram-negative cells.

20 April 2023

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Structure-activity relations in antifungal agents. A survey

20 April 2023

175

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Use of van der Waals volume in structure-activity studies

20 April 2023

177

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Quantitative structure-activity relationship of chymotrypsin-ligand interactions

20 April 2023

178

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Design, synthesis, and correlation analysis of 7-substituted 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cellular respiration

20 April 2023

179

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20 April 2023

Parachors in drug design

180

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Comparison of parameters currently used in the study of structure-activity relationships

20 April 2023

182

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Alpha-chymotrypsin: a case study of substituent constants and regression analysis in enzymic structure--activity relationships

20 April 2023

184

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An analysis of the structure-activity relationship in the adrenergic blocking activity of the beta-haloalkylamines

20 April 2023

186

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Interrelation of the regression models used for structure-activity analyses

20 April 2023

187

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On model building in structure-activity relationships. A reexamination of adrenergic blocking activity of beta-halo-beta-arylalkylamines.

20 April 2023

188

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Quantitative structure-activity relationships. 1. The modified Free-Wilson approach

20 April 2023

189

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Structure-activity relations in papain-ligand interactions

20 April 2023

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Structure-activity relationships in papain and bromelain ligand interactions

20 April 2023

194

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Correlation analysis of Baker's studies on enzyme inhibition. 2. Chymotrypsin, trypsin, thymidine phosphorylase, uridine phosphorylase, thymidylate synthetase, cytosine nucleoside deaminase, dihydrofolate reductase, malate dehydrogenase, glutamate d

20 April 2023

195

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Quantitative structure-activity relation of reversible dihydrofolate reductase inhibitors. Diaminotriazines

20 April 2023

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Correlation analysis of Baker's studies on enzyme inhibition. 1. Guanine deaminase, xanthine oxidase, dihydrofolate reductase, and complement

20 April 2023

197

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Quantitative structure-activity relation of antimalarial and dihydrofolate reductase inhibition by quinazolines and 5-substituted benzyl-2,4-diaminopyrimidines

20 April 2023

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The use of substituent constants in the quantitative treatment of hapten-antibody interaction

20 April 2023

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Structure-activity relationships in immunochemistry--V. The interaction of phenylsuccinamates and pyridine haptens with anti-3-azopyridine antibody

20 April 2023

202

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Structure-activity relationships in immunochemistry. 2. Inhibition of complement by benzamidines

20 April 2023

203

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Structure-activity relationships in immunochemistry. III. Inhibition of complement by benzyl pyridinium ions

20 April 2023

204

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Structure-activity relationships in immunochemistry. 4. Inhibition of complement by benzylpyridinium ions. On the predictive value of correlation equations

20 April 2023

205

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Relationships among Current Quantitative Structure-Activity Models

20 April 2023

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Quantitative structure-activity relationships. 2. A mixed approach, based on Hansch and Free-Wilson Analysis

20 April 2023

208

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Thyroxine analogs. 23. Quantitative structure-activity correlation studies of in vivo and in vitro thyromimetic activities

20 April 2023

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Effect of colloidal association on the measured activity of alkylbenzyldimethylammonium chlorides against Pseudomonas aeruginosa

20 April 2023

212

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Effect of chain length on critical micelle formation and protein binding of quaternary ammonium compounds

20 April 2023

213

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Effects of 8-substituted adenosine 3',5'-monophosphate derivatives on high Kmphosphodiesterase activity

20 April 2023

214

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Liver alcohol dehydrogenase inhibition by fatty acid amides, N-alkylformamides and monoalkylureas

20 April 2023

215

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Parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics

20 April 2023

216

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Quantitative structure-activity relationships of chymotrypsin. On the predictive value of correlation equations

20 April 2023

218

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Correlation analysis. Its application to the structure-activity relation of triazines inhibiting dihydrofolate reductase

20 April 2023

219

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Relationship between lipophilic character and anesthetic activity.

20 April 2023

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Structure-activity correlations of antimalarial compounds. 2. Phenanthreneaminoalkylcarbinol antimalarials

20 April 2023

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Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 1. Quantitative structure-activity relationships vs. L1210 leukemia in mice

20 April 2023

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Quantitative structure--activity relationships. 7. The bilinear model, a new model for nonlinear dependence of biological activity on hydrophobic character

20 April 2023

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On the parabolic relationship between biological activity and hydrophobicity of drugs: transport or protein binding?

20 April 2023

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