(Q39858021)

15 September 2017

Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity (English)

1 reference

15 September 2017

3

1 reference

15 September 2017

Ji-Liang Li

1

1 reference

PubMed ID

20624122

15 September 2017

Adrian M Jubb

series ordinal

2

1 reference

PubMed ID

20624122

15 September 2017

language of work or name

English

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publication date

1 July 2010

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15 September 2017

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15 September 2017

6

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15 September 2017

1099-1103

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15 September 2017

7

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Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis

15 September 2017

1 reference

Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer

21 January 2018

1 reference

Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer

21 January 2018

1 reference

Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo.

21 January 2018

1 reference

Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer

21 January 2018

1 reference

Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function

21 January 2018

1 reference

DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

21 January 2018

1 reference

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

21 January 2018

1 reference

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

21 January 2018

1 reference

Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion

21 January 2018

1 reference

Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications

21 January 2018

1 reference

Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles.

21 January 2018

1 reference

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

21 January 2018

1 reference

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

21 January 2018

1 reference

Chronic DLL4 blockade induces vascular neoplasms

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FON.10.62

1 reference

15 September 2017

1 reference

PubMed ID

20624122