(Q39860473)

English

The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL.

scientific article published on 16 April 2009

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scholarly article

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26 January 2020

The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL (English)

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26 January 2020

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26 January 2020

1

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26 January 2020

Martin Ruthardt

8

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26 January 2020

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M Schüll

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26 January 2020

Z Zhao

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26 January 2020

C Oancea

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26 January 2020

A Hundertmark

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26 January 2020

T Beissert

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26 January 2020

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16 April 2009

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26 January 2020

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26 January 2020

23

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26 January 2020

9

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26 January 2020

1614-1621

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26 January 2020

https://scigraph.springernature.com/pub.10.1038/leu.2009.69

0 references

The biology of chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

Therapy options in imatinib failures

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

Imatinib (STI571) resistance in chronic myelogenous leukemia: molecular basis of the underlying mechanisms and potential strategies for treatment

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

Translation of the Philadelphia chromosome into therapy for CML.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

Targeting of the N-terminal coiled coil oligomerization interface by a helix-2 peptide inhibits unmutated and imatinib-resistant BCR/ABL.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

An intramolecular SH3-domain interaction regulates c-Abl activity

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

Activation of tyrosine kinases by mutation of the gatekeeper threonine

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

21 January 2018

Resistance to imatinib: mechanisms and management

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

7 January 2021

based on heuristic

inferred from DOI database lookup

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2009.69

7 January 2021

based on heuristic

inferred from DOI database lookup

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