(Q39868726)

English

Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer.

scientific article published on 24 March 2009

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

Katherine R. Calvo

11

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

author name string

Francisco G Pernas

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

Clint T Allen

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

Mary E Winters

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

Bin Yan

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

Jay Friedman

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

Bhavana Dabir

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

Kunal Saigal

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

Gerhard S Mundinger

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

John C Morris

10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

Carter Van Waes

12

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

Zhong Chen

13

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

language of work or name

0 references

publication date

24 March 2009

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

Clinical Cancer Research

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

15

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

2361-2372

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6689817/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL-6: a general role for inflammation?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concurrent paclitaxel and radiation in the treatment of locally advanced head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of constitutively activated EGFRvIII in non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K/Akt and apoptosis: size matters

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling to NF-kappaB

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The epidermal growth factor receptor signaling network in head and neck carcinogenesis and implications for targeted therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological significance of c-erbB family oncogenes in head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through Egr-1 in head and neck squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical proteomics: from biomarker discovery and cell signaling profiles to individualized personal therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor receptor biology in head and neck cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological and clinical implications of EGFR mutations in lung cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gefitinib (IRESSA) sensitive lung cancer cell lines show phosphorylation of Akt without ligand stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor receptor inhibition sensitizes renal cell carcinoma cells to the cytotoxic effects of bortezomib.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor-kappaB in development, prevention, and therapy of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling through RAS-RAF-MEK-ERK: from basics to bedside.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Database of somatic mutations in EGFR with analyses revealing indel hotspots but no smoking-associated signature

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-kappaB and other signal transcription factors in head and neck squamous cell carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT-mediated EGFR signaling in cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization, quantification, and potential clinical value of the epidermal growth factor receptor in head and neck squamous cell carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19318490

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1078-0432.CCR-08-1011

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6689817&resulttype=core&format=json

11 May 2020

ResearchGate publication ID

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