(Q39879662)

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Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy

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Europe PubMed Central

PMC publication ID

15 September 2017

Silencing of elongation factor-2 kinase potentiates the effect of 2-deoxy-D-glucose against human glioma cells through blunting of autophagy (English)

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Europe PubMed Central

PMC publication ID

15 September 2017

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author name string

Hao Wu

1

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Europe PubMed Central

PMC publication ID

15 September 2017

Hua Zhu

2

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Europe PubMed Central

PMC publication ID

15 September 2017

David X Liu

3

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

Ting-Kuang Niu

4

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Europe PubMed Central

PMC publication ID

15 September 2017

Xingcong Ren

5

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Europe PubMed Central

PMC publication ID

15 September 2017

Rajesh Patel

6

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Europe PubMed Central

PMC publication ID

15 September 2017

William N Hait

7

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Europe PubMed Central

PMC publication ID

15 September 2017

Jin-Ming Yang

8

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Europe PubMed Central

PMC publication ID

15 September 2017

language of work or name

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publication date

24 February 2009

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Europe PubMed Central

PMC publication ID

15 September 2017

Cancer Research

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Europe PubMed Central

PMC publication ID

15 September 2017

69

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Europe PubMed Central

PMC publication ID

15 September 2017

6

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

2453-2460

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.

1 reference

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1 reference

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Laforin confers cancer resistance to energy deprivation-induced apoptosis

1 reference

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Modulation of the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose

1 reference

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2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer

1 reference

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Autophagy as a second level protective process in conferring resistance to environmentally-induced oxidative stress

1 reference

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1 reference

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The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco/endoplasmic reticulum calcium stores

1 reference

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1 reference

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1 reference

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Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism

1 reference

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22 September 2017

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1 reference

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1 reference

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22 September 2017

Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

22 September 2017

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

22 September 2017

p53 regulates mitochondrial respiration

1 reference

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22 September 2017

Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

22 September 2017

A matter of life or death (or both): understanding autophagy in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

22 September 2017

Elongation factor-2 kinase regulates autophagy in human glioblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

22 September 2017

Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

22 September 2017

Lysosomes and autophagy in cell death control

1 reference

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22 September 2017

AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress

1 reference

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22 September 2017

Regulation of neuron survival and death by p130 and associated chromatin modifiers

1 reference

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22 September 2017

2-deoxy-D-glucose enhances the cytotoxicity of topoisomerase inhibitors in human tumor cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

22 September 2017

Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

22 September 2017

Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines

1 reference

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22 September 2017

On respiratory impairment in cancer cells

1 reference

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On the Origin of Cancer Cells

1 reference

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Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

22 September 2017

Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

22 September 2017

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

22 September 2017

Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer

1 reference

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22 September 2017

Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

22 September 2017

Role of calmodulin-dependent phosphorylation of elongation factor 2 in the proliferation of rat glial cells

1 reference

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22 September 2017

Hexokinase: The Direct Link between Mitochondrial and Glycolytic Reactions in Rapidly Growing Cancer Cells

1 reference

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22 September 2017

Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines

1 reference

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2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells

1 reference

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Phosphorylation of elongation factor 2 in normal and malignant rat glial cells

1 reference

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1 reference

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1 reference

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20 August 2018

Question 7: optimized energy consumption for protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

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Effect of 2-deoxy-D-glucose on various malignant cell lines in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2907516

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Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim.

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2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro

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20 August 2018

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1 reference

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20 August 2018

2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism.

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Cell cycle arrest and astrocytic differentiation resulting from PTEN expression in glioma cells.

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Ca2+/calmodulin-dependent phosphorylation of elongation factor 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/19244119

12 December 2020

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Identifiers

10.1158/0008-5472.CAN-08-2872

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 September 2017

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