(Q39885131)

English

A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis

scientific article published on 10 February 2009

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scholarly article

1 reference

Europe PubMed Central

15 September 2017

A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis (English)

1 reference

Europe PubMed Central

15 September 2017

apoptotic process

0 references

mitochondrial DNA

0 references

reactive oxygen species

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Jeong Soon Park

1

1 reference

Europe PubMed Central

15 September 2017

Lokendra Kumar Sharma

2

1 reference

Europe PubMed Central

15 September 2017

Hongzhi Li

3

1 reference

Europe PubMed Central

15 September 2017

Ruihua Xiang

4

1 reference

Europe PubMed Central

15 September 2017

Deborah Holstein

5

1 reference

Europe PubMed Central

15 September 2017

Jun Wu

6

1 reference

Europe PubMed Central

15 September 2017

James Lechleiter

7

1 reference

Europe PubMed Central

15 September 2017

Susan L Naylor

8

1 reference

Europe PubMed Central

15 September 2017

Janice J Deng

9

1 reference

Europe PubMed Central

15 September 2017

Jianxin Lu

10

1 reference

Europe PubMed Central

15 September 2017

Yidong Bai

11

1 reference

Europe PubMed Central

15 September 2017

publication date

10 February 2009

1 reference

Europe PubMed Central

15 September 2017

Human Molecular Genetics

1 reference

Europe PubMed Central

15 September 2017

18

1 reference

Europe PubMed Central

15 September 2017

9

1 reference

Europe PubMed Central

15 September 2017

1578-1589

1 reference

Europe PubMed Central

15 September 2017

Inhibition of apoptotic potency by ligand stimulated thyroid hormone receptors located in mitochondria

1 reference

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22 September 2017

Biochemical phenotypes associated with the mitochondrial ATP6 gene mutations at nt8993.

1 reference

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22 September 2017

Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: a biomarker for the early detection of cancer

1 reference

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22 September 2017

Caspase-8 dependent TRAIL-induced apoptosis in cancer cell lines is inhibited by vitamin C and catalase

1 reference

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22 September 2017

Mitochondrial DNA mutations in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Mitochondrial mutations in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Nuclear suppression of mitochondrial defects in cells without the ND6 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Enhanced ROS production and antioxidant defenses in cybrids harbouring mutations in mtDNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Possibility of selection against mtDNA mutations in tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Cytotoxic effects induced by oxidative stress in cultured mammalian cells and protection provided by Hsp27 expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

mtDNA mutations increase tumorigenicity in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

mtDNA variation, climatic adaptation, degenerative diseases, and longevity

1 reference

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22 September 2017

Genetic and functional analysis of mitochondrial DNA-encoded complex I genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Maternally inherited aminoglycoside-induced and nonsyndromic deafness is associated with the novel C1494T mutation in the mitochondrial 12S rRNA gene in a large Chinese family

1 reference

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22 September 2017

On the Origin of Cancer Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Oxidant signals and oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation

1 reference

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22 September 2017

Mitochondrial DNA in human malignancy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Mitochondrial genetics and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Redox-dependent signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Tight control of respiration by NADH dehydrogenase ND5 subunit gene expression in mouse mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Somatic mutations of the mitochondrial genome in human colorectal tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Efficient selection and characterization of mutants of a human cell line which are defective in mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

22 September 2017

Tumor Mitochondria and the Bioenergetics of Cancer Cells

1 reference

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22 September 2017

Early redox imbalance mediates hydroperoxide-induced apoptosis in mitotic competent undifferentiated PC-12 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

25 September 2017

Genomic stability and instability: a working paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

25 September 2017

Reactive oxygen species in tumorigenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

25 September 2017

Lactic acidosis and other mitochondrial disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2733816

25 September 2017

An essential role for free radicals and derived species in signal transduction.

1 reference

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25 September 2017

Early superoxide dismutase-sensitive event promotes neoplastic transformation in mouse epidermal JB6 cells

1 reference

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Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung can

1 reference

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20 August 2018

Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis

1 reference

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20 August 2018

The bioenergetic signature of cancer: a marker of tumor progression.

1 reference

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20 August 2018

Serum copper/zinc superoxide dismutase (Cu/Zn SOD) and gastric cancer risk: a case-control study.

1 reference

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20 August 2018

Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.

1 reference

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20 August 2018

The permissive role of oxygen-derived free radicals in the development of colonic cancer in the rat. A new theory for carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19208652

12 December 2020

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Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/19208652

12 December 2020

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inferred from PubMed ID database lookup

Novel mitochondrial DNA deletion found in a renal cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19208652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relevance of mitochondrial DNA in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19208652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondria, from cell death to proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19208652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide induces and inhibits apoptosis through different pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/19208652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic mutations of mitochondrial genome in early stage breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19208652

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/HMG/DDP069

1 reference

Europe PubMed Central

15 September 2017

release_uipd4giqyzcxlcnyof4p64w7ly

1 reference

https://api.fatcat.wiki/v0/release/uipd4giqyzcxlcnyof4p64w7ly

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

15 September 2017

1 reference

Europe PubMed Central

15 September 2017

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