(Q39895074)

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Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease.

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19 January 2020

Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease (English)

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19 January 2020

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19 January 2020

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19 January 2020

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Terry D Butters

2

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19 January 2020

Stephanie D Boomkamp

4

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19 January 2020

Raymond A Dwek

5

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19 January 2020

Naoki Asano

6

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19 January 2020

Kyoko Ikeda

7

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19 January 2020

Emma L Evinson

8

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19 January 2020

Robert J Nash

9

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19 January 2020

George W J Fleet

10

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19 January 2020

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1 March 2009

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19 January 2020

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19 January 2020

4

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19 January 2020

3

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19 January 2020

378-392

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19 January 2020

Biochemical consequences of mutations causing the GM2 gangliosidoses

1 reference

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Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins

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Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases

1 reference

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Quantitative correlation between the residual activity of beta-hexosaminidase A and arylsulfatase A and the severity of the resulting lysosomal storage disease

1 reference

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Splice junction mutation in some Ashkenazi Jews with Tay-Sachs disease: evidence against a single defect within this ethnic group

1 reference

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7 January 2021

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Identification of an altered splice site in Ashkenazi Tay-Sachs disease

1 reference

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7 January 2021

based on heuristic

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Hexosaminidase-A and hexosaminidase-B: studies in Tay-Sachs' and Sandhoff's disease

1 reference

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Enzyme replacement and enhancement therapies: lessons from lysosomal disorders

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7 January 2021

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New therapeutic prospects for the glycosphingolipid lysosomal storage diseases.

1 reference

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1 reference

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7 January 2021

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Accelerated transport and maturation of lysosomal α–galactosidase A in Fabry lymphoblasts by an enzyme inhibitor

1 reference

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7 January 2021

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In vitro inhibition and intracellular enhancement of lysosomal α-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800350

7 January 2021

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inferred from DOI database lookup

A contradictory treatment for lysosomal storage disorders: inhibitors enhance mutant enzyme activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800350

7 January 2021

based on heuristic

inferred from DOI database lookup

Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800350

7 January 2021

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inferred from DOI database lookup

Setting the standards: quality control in the secretory pathway

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacological enhancement of beta-hexosaminidase activity in fibroblasts from adult Tay-Sachs and Sandhoff Patients.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800350

7 January 2021

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Polyhydroxylated alkaloids -- natural occurrence and therapeutic applications

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7 January 2021

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Iminosugar-producing Thai medicinal plants

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Long-term effectiveness of a new alpha-glucosidase inhibitor (BAY m1099-miglitol) in insulin-treated type 2 diabetes mellitus

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7 January 2021

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Therapeutic applications of imino sugars in lysosomal storage disorders

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https://api.crossref.org/works/10.1002%2FCMDC.200800350

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Glycosidase inhibitors as potential HIV entry inhibitors?

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7 January 2021

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Iminosugars and relatives as antiviral and potential anti-infective agents.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800350

7 January 2021

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Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents

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The chemistry of the 1-deoxynojirimycin system. Synthesis of 2-acetamido-1,2-dideoxynojirimycin from 1-deoxynojirimycin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800350

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and activity of 1-N-iminosugar inhibitors, siastatin B analogues for alpha-N-acetylgalactosaminidase and beta-N-acetylglucosaminidase

1 reference

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7 January 2021

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NAG-thiazoline, An N -Acetyl-β-hexosaminidase Inhibitor That Implicates Acetamido Participation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800350

7 January 2021

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Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids

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7 January 2021

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Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP.

1 reference

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7 January 2021

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Biological properties of D- and L-1-deoxyazasugars

1 reference

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7 January 2021

based on heuristic

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[Synthesis of 2-acetamido-1,4-imino-1,2,4-tridesoxy-D-galactitol and competitive inhibition of human lysosomal beta-hexosaminidase A]

1 reference

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7 January 2021

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Membrane disruption and cytotoxicity of hydrophobic N-alkylated imino sugars is independent of the inhibition of protein and lipid glycosylation

1 reference

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7 January 2021

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The conformational effects of N-glycosylation on the tailpiece from serum IgM.

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1 reference

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Identifiers

10.1002/CMDC.200800350

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19145603%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19145603%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

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