(Q39905162)

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Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19082571%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19082571%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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1 reference

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Thomas K Felder

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19082571%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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Hannes Oberkofler

1

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18 January 2020

Michael Hafner

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19082571%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Franz Krempler

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19082571%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Wolfgang Patsch

5

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Europe PubMed Central

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18 January 2020

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11 December 2008

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Europe PubMed Central

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18 January 2020

Journal of Molecular Medicine

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19082571%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

87

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Europe PubMed Central

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18 January 2020

3

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Europe PubMed Central

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18 January 2020

299-306

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Europe PubMed Central

PubMed publication ID

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18 January 2020

https://scigraph.springernature.com/pub.10.1007/s00109-008-0425-0

0 references

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Foxa2 regulates multiple pathways of insulin secretion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Diabetic Zucker Fatty Rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PGC-1beta in the regulation of hepatic glucose and energy metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of beta cell energy metabolism and insulin release by PGC-1alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Granuphilin molecularly docks insulin granules to the fusion machinery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uncoupling protein 2 and islet function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the role of uncoupling protein-2 in pancreatic beta cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective association of sterol regulatory element-binding protein isoforms with target promoters in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules

1 reference

https://pubmed.ncbi.nlm.nih.gov/19082571

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00109-008-0425-0

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19082571%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19082571%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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