(Q39905970)

English

The Timothy syndrome mutation of cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation.

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19074970%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

The Timothy syndrome mutation of cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19074970%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Timothy syndrome

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Keith S Elmslie

4

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18 January 2020

author name string

Viktor Yarotskyy

1

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18 January 2020

Guofeng Gao

2

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18 January 2020

Blaise Z Peterson

3

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18 January 2020

language of work or name

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publication date

15 December 2008

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18 January 2020

Journal of Physiology

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18 January 2020

587

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18 January 2020

551-565

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18 January 2020

3

1 reference

Europe PubMed Central

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18 January 2020

The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670080

30 August 2018

The separation of antagonist from agonist effects of trisubstituted purines on CaV2.2 (N-type) channels.

1 reference

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30 August 2018

A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates

1 reference

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30 August 2018

Roscovitine, a cyclin-dependent kinase inhibitor, affects several gating mechanisms to inhibit cardiac L-type (Ca(V)1.2) calcium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670080

30 August 2018

Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: effects of ranolazine

1 reference

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30 August 2018

Calcium and arrhythmogenesis

1 reference

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30 August 2018

A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days

1 reference

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30 August 2018

Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation.

1 reference

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30 August 2018

Roscovitine differentially affects CaV2 and Kv channels by binding to the open state.

1 reference

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30 August 2018

Effects of L-type Ca2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3.

1 reference

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30 August 2018

The role of the GX9GX3G motif in the gating of high voltage-activated Ca2+ channels.

1 reference

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30 August 2018

Verapamil decreases ventricular tachyarrhythmias in a patient with Timothy syndrome (LQT8).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670080

30 August 2018

Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670080

30 August 2018

Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670080

30 August 2018

Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations

1 reference

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30 August 2018

Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau.

1 reference

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30 August 2018

The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670080

30 August 2018

Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism

1 reference

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30 August 2018

Calcium channel blockers in the treatment of disease.

1 reference

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30 August 2018

A quantitative description of membrane current and its application to conduction and excitation in nerve

1 reference

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30 August 2018

Functional roles of cytoplasmic loops and pore lining transmembrane helices in the voltage-dependent inactivation of HVA calcium channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670080

30 August 2018

CDK inhibitors in clinical development for the treatment of cancer

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30 August 2018

Engineered calmodulins reveal the unexpected eminence of Ca2+ channel inactivation in controlling heart excitation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670080

30 August 2018

Calcium and cardiac rhythms: physiological and pathophysiological

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670080

30 August 2018

Immobilizing the moving parts of voltage-gated ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670080

30 August 2018

Cardiac ionic currents and acute ischemia: from channels to arrhythmias

1 reference

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30 August 2018

A region in IVS5 of the human cardiac L-type calcium channel is required for the use-dependent block by phenylalkylamines and benzothiazepines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670080

30 August 2018

Independent versus coupled inactivation in sodium channels. Role of the domain 2 S4 segment

1 reference

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30 August 2018

Sodium channel inactivation is altered by substitution of voltage sensor positive charges

1 reference

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30 August 2018

A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670080

30 August 2018

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

1 reference

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30 August 2018

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

1 reference

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30 August 2018

A unique role for the S4 segment of domain 4 in the inactivation of sodium channels

1 reference

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30 August 2018

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists

1 reference

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30 August 2018

Heterologous regulation of the cardiac Ca2+ channel alpha 1 subunit by skeletal muscle beta and gamma subunits. Implications for the structure of cardiac L-type Ca2+ channels

1 reference

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30 August 2018

Beta-adrenergic stimulation of calcium channels occurs by potentiation of high-activity gating modes

1 reference

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1 reference

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30 August 2018

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1 reference

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30 August 2018

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1 reference

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30 August 2018

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1 reference

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1 October 2018

Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block

1 reference

https://pubmed.ncbi.nlm.nih.gov/19074970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-type Ca2+ channel mutations and T-wave alternans: a model study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19074970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/19074970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/19074970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1113/JPHYSIOL.2008.161737

1 reference

Europe PubMed Central

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18 January 2020

release_gkvedaqppzbnti6oh4i2gng6wa

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24 November 2022

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mapped directly with Wikidata item

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1 reference

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18 January 2020

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