(Q39907656)

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Regulatory effect of extracellular signal-regulated kinases (ERK) on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL-13.

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Europe PubMed Central

PubMed publication ID

15 September 2017

Regulatory effect of extracellular signal-regulated kinases (ERK) on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL-13. (English)

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

author name string

Rashpal K Bhogal

1

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

Constantin A Bona

2

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Europe PubMed Central

PubMed publication ID

15 September 2017

publication date

1 January 2008

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Europe PubMed Central

PubMed publication ID

15 September 2017

International Reviews of Immunology

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Europe PubMed Central

PubMed publication ID

15 September 2017

27

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Europe PubMed Central

PubMed publication ID

15 September 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

472-496

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

Regulation of connective tissue synthesis in systemic sclerosis.

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Molecular mechanisms of pulmonary fibrosis

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TGF-beta signaling and the fibrotic response

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Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts

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Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4

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Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathway

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IL-6 induces hepatic inflammation and collagen synthesis in vivo.

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Overlapping pathways mediate the opposing actions of tumor necrosis factor-alpha and transforming growth factor-beta on alpha 2(I) collagen gene transcription

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Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts.

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TGF-beta signal transduction

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Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts

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Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma

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Involvement of ERK signaling in halofuginone-driven inhibition of fibroblast ability to contract collagen lattices.

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MAP-kinase activity necessary for TGFbeta1-stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397.

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Regulation of MAPKs by growth factors and receptor tyrosine kinases

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The MEK/ERK cascade: from signaling specificity to diverse functions

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Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

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Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

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A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun

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MAPK phosphatases--regulating the immune response

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Multiple Ras functions can contribute to mammalian cell transformation

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Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

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Mxi2 promotes stimulus-independent ERK nuclear translocation

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ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter

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Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms

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Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma

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Molecular aspects of regulation of collagen gene expression in fibrosis.

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IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis

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MAP kinase modules: many roads home.

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The roles of MAPKs in disease

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Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype

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Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function.

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Evidence for three major transcription activation elements in the proximal mouse proalpha2(I) collagen promoter

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A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming growth factor-beta type II receptor

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Identifiers

10.1080/08830180802430974

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 September 2017

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