(Q39926217)

English

Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: functional relevance of iron, the receptor, and reactive oxygen species.

scientific article published on 23 October 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18946492%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: functional relevance of iron, the receptor, and reactive oxygen species (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18946492%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

0 references

reactive oxygen species

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Gustavo Helguera

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18946492%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

author name string

E Ortiz-Sánchez

1

1 reference

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24 December 2019

T R Daniels

2

1 reference

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24 December 2019

O Martinez-Maza

4

1 reference

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24 December 2019

B Bonavida

5

1 reference

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24 December 2019

M L Penichet

6

1 reference

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24 December 2019

publication date

23 October 2008

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24 December 2019

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18946492%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

23

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24 December 2019

1

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24 December 2019

59-70

1 reference

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24 December 2019

https://scigraph.springernature.com/pub.10.1038/leu.2008.270

0 references

Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells.

1 reference

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Binding specificity and internalization properties of an antibody-avidin fusion protein targeting the human transferrin receptor.

1 reference

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Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes

1 reference

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Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway

1 reference

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Altered immunity as a risk factor for non-Hodgkin lymphoma

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Iron homeostasis

1 reference

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22 September 2017

Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells

1 reference

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The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells

1 reference

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The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer

1 reference

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22 September 2017

Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor.

1 reference

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22 September 2017

Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells

1 reference

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22 September 2017

Reactive oxygen species mediate crosstalk between NF-kappaB and JNK.

1 reference

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22 September 2017

Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells

1 reference

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22 September 2017

A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid

1 reference

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22 September 2017

Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823

1 reference

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22 September 2017

Prostaglandin D(2) and J(2) induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen species

1 reference

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22 September 2017

Rituximab (chimeric anti-CD20 monoclonal antibody) inhibits the constitutive nuclear factor-{kappa}B signaling pathway in non-Hodgkin's lymphoma B-cell lines: role in sensitization to chemotherapeutic drug-induced apoptosis.

1 reference

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22 September 2017

Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells

1 reference

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22 September 2017

Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin's lymphoma B cells by Rituximab.

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22 September 2017

Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3739978

22 September 2017

Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay

1 reference

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Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum

1 reference

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An anti-transferrin receptor-avidin fusion protein exhibits both strong proapoptotic activity and the ability to deliver various molecules into cancer cells

1 reference

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15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis

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Mitochondrial reactive oxygen species in cell death signaling

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Role of reactive oxygen species (ROS) in apoptosis induction

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Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family

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H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

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Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptor

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Identifiers

10.1038/LEU.2008.270

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18946492%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18946492%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18946492%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

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