(Q39947679)

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A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723515%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723515%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

G protein-coupled receptor

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Patrick M. Sexton

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723515%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1

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12 January 2020

5

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12 January 2020

author name string

Karen J Gregory

2

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12 January 2020

Nathan E Hall

3

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12 January 2020

Peter J Scammells

4

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12 January 2020

Arthur Christopoulos

7

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12 January 2020

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publication date

22 August 2008

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12 January 2020

number of pages

10

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Journal of Biological Chemistry

1 reference

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12 January 2020

283

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12 January 2020

43

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723515%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

29312-29321

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723515%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Structural diversity of G protein-coupled receptors and significance for drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- d -aspartate receptor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

G protein-coupled receptor allosterism and complexing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Seven-transmembrane receptors: crystals clarify

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Qualitative and quantitative assessment of relative agonist efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Drugs from emasculated hormones: the principle of syntopic antagonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Dimethylsulfonium analogues of the muscarinic agent McN-A-343: [4-[[N-(3- or 4-halophenyl)carbamoyl]oxy]-2-butynyl] dimethylsulfonium perchlorates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

22 September 2017

Site-directed mutagenesis of the putative human muscarinic M2 receptor binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

25 September 2017

International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

15 June 2018

Estimation of partial agonist affinity by interaction with a full agonist: a direct operational model-fitting approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

15 June 2018

Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

15 June 2018

Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

20 August 2018

Allosteric binding sites on muscarinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

20 August 2018

Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

20 August 2018

Assessing the distribution of parameters in models of ligand-receptor interaction: to log or not to log.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

20 August 2018

Pharmacological analysis of the mode of interaction of McN-A-343 at atrial muscarinic M2 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2662018

20 August 2018

Allosteric Modulation of G Protein–Coupled Receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803801200

21 January 2018

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803801200

21 January 2018

Evidence for a multiple binding mode of bispyridinium-type allosteric modulators of muscarinic receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803801200

21 January 2018

Transducer abstraction: a novel approach to the detection of partial agonist efficacy in radioligand binding studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18723515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationships among a series of acetylenic carbamates related to McN-A343

1 reference

https://pubmed.ncbi.nlm.nih.gov/18723515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of drugs competing with d-tubocurarine for an allosteric site on cardiac muscarinic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18723515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18723515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations of aspartate 103 in the Hm2 receptor and alterations in receptor binding properties of muscarinic agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/18723515

12 December 2020

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An unusual type of sympathetic ganglionic stimulant

1 reference

https://pubmed.ncbi.nlm.nih.gov/18723515

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M803801200

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723515%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723515%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18723515%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

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